Hipertiroidili Hastalarda Tedavinin Beyin Natriüretik Peptid Düzeyine Etkisi
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Tarih
11.09.2020
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info:eu-repo/semantics/openAccess
Özet
Amaç: Kardiyak problemi ve herhangi bir sistemik hastalığı olmayan hipertiroidili hastalarda beyin natriüretrik peptid (BNP) düzeyini ve tedavinin BNP düzeyine etkisini değerlendirmeyi planladık. Gereç ve Yöntemler: Çalışmaya 29 hipertiroidili ve 30 sağlıklı olgu dahil edildi. Hastalarda total T3, total T4, serbest T3, serbest T4, TSH, anti TPOAb, Anti TgAb ve BNP düzeylerine tedavi öncesinde ve ötiroid olduktan sonra bakıldı. Bulgular: Hipertiroidili hastalarının tedavi öncesi BNP düzeyleri kontrol grubuna göre anlamlı olarak daha yüksek bulunmuştur (P<0,05). Hastaların tedavi öncesi ve ötiroid olduktan sonraki BNP düzeyleri arasında anlamlı ilişki saptanmıştır (P<0,05). TT3 ve Anti TPOAb ile BNP arasında pozitif bir korelasyon gözlenmiştir (P<0,05). BNP ile TSH arasında ise tedavi öncesi ve sonrası anlamlı bir korelasyon saptanmamıştır (P>0,05). Ayrıca hastalarda Anti TgAb, ST3, ST4 ve TT4’de tedavi öncesi pozitif bir korelasyon gözlenmiş (P<0,05) olup tedavi sonrası ise korelasyon tespit edilmemiştir (P>0,05). Sonuç: Hipertiroidili hastalarda BNP düzeyi artmıştır. Antitiroid tedavi BNP düzeyini anlamlı olarak düşürmektedir.
Objective: We aimed to evaluate the Brain Natriuretic Peptide (BNP) levels in patients with hyperthyroidism who do not suffer any cardiac problems or systemic diseases and the effect of the treatment on the BNP levels as well. Material and Methods: 29 hyperthyroid patients and 30 healthy subjects participated in the study. The patients were checked for their total T3, total T4, free T3, free T4, TSH, anti TPOAb, Anti TgAb, and BNP levels before and after treatment period. Results: BNP levels of patients with hyperthyroidism before treatment were found to be significantly higher than the control group (P <0.05). A significant correlation was found between the BNP levels of the patients before and after they became euthyroid (P <0.05). A positive correlation was observed between TT3 and Anti TPOAb and BNP (P <0.05). There was no significant correlation between BNP and TSH before and after treatment (P> 0.05). In addition, a positive correlation was observed in Anti TgAb, ST3, ST4 and TT4 before treatment (P <0.05), but no correlation was found after treatment (P> 0.05). Conclusion:BNP level is increased in patients with hyperthyroidism. Antithyroid therapy significantly reduces the BNP level.
Objective: We aimed to evaluate the Brain Natriuretic Peptide (BNP) levels in patients with hyperthyroidism who do not suffer any cardiac problems or systemic diseases and the effect of the treatment on the BNP levels as well. Material and Methods: 29 hyperthyroid patients and 30 healthy subjects participated in the study. The patients were checked for their total T3, total T4, free T3, free T4, TSH, anti TPOAb, Anti TgAb, and BNP levels before and after treatment period. Results: BNP levels of patients with hyperthyroidism before treatment were found to be significantly higher than the control group (P <0.05). A significant correlation was found between the BNP levels of the patients before and after they became euthyroid (P <0.05). A positive correlation was observed between TT3 and Anti TPOAb and BNP (P <0.05). There was no significant correlation between BNP and TSH before and after treatment (P> 0.05). In addition, a positive correlation was observed in Anti TgAb, ST3, ST4 and TT4 before treatment (P <0.05), but no correlation was found after treatment (P> 0.05). Conclusion:BNP level is increased in patients with hyperthyroidism. Antithyroid therapy significantly reduces the BNP level.
Açıklama
Anahtar Kelimeler
Hipertiroidi, Beyin natriüretrik peptid, Antitiroid tedavi, Hyperthyroidism, Brain natriuretic peptide, Antithyroid therapy
Kaynak
KSU Medical Journal
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Scopus Q Değeri
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Künye
KARAGÖZ, Z. K., ŞAHİN, İ., KANAT, B. H., & Feyzi, K. U. R. T. Hipertiroidili Hastalarda Tedavinin Beyin Natriüretik Peptid Düzeyine Etkisi. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi, 16(2), 279-284.
