Ratlarda siklofosfamid kaynaklı kardiyotoksisite üzerine timokinonun etkileri
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Malatya Turgut Ozal University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Antineoplastik kemoterapide kullanılan bir ajan olan siklofosfamidin (CP) birçok doku üzerinde toksik etkisi bulunmaktadır. Bu çalışmada siklofosfamidin oluşturduğu kardiyotoksisiteye karşı çörek otu uçucu yağının baskın bileşeni olan Timokinonun (TQ) koruyucu etkileri araştırıldı. Materyal ve Metot: Bu amaçla 32 adet 8 haftalık erkek Sprague Dawley sıçan 4 eşit gruba ayrıldı (n=8). Kontrol, TQ (10 mg/kg/gün, oral gavaj), CP (50 mg/kg, i.p., 1, 8, 15 ve 22. günlerde) ve TQ+CP (TQ 10 mg/kg/gün, oral gavaj ve CP 50 mg/kg, i.p., 1, 8, 15 ve 22. günlerde). Dört haftalık uygulamaların ardından kalp dokusunda histopatolojik ve biyokimyasal analizler yapıldı. Bulgular: Kalp dokusunda CP’nin malondialdehit (MDA) seviyelerinde belirgin artışlara sebep olduğu (p
Background: Cyclophosphamide (CP), an agent used in antineoplastic chemotherapy, has toxic effects on many tissues. In this study, the protective effects of thymoquinone (TQ), the dominant component of black cumin essential oil, against cyclophosphamide-induced cardiotoxicity were investigated. Materials and Methods: Thirty-two 8-week-old male Sprague Dawley rats were divided into 4 groups (n=8); control, TQ (10 mg/kg/day, oral gavage), CP (50 mg/kg, i.p., on days 1, 8, 15 and 22), and TQ+CP (TQ 10 mg/kg/day, oral gavage and CP 50 mg/kg, i.p. on days 1, 8, 15 and 22). After four weeks of applications, histopathological and biochemical analyzes were performed on heart tissues. Results: It was observed that CP caused a significant increase in malondialdehyde (MDA) levels in heart tissues (p
Background: Cyclophosphamide (CP), an agent used in antineoplastic chemotherapy, has toxic effects on many tissues. In this study, the protective effects of thymoquinone (TQ), the dominant component of black cumin essential oil, against cyclophosphamide-induced cardiotoxicity were investigated. Materials and Methods: Thirty-two 8-week-old male Sprague Dawley rats were divided into 4 groups (n=8); control, TQ (10 mg/kg/day, oral gavage), CP (50 mg/kg, i.p., on days 1, 8, 15 and 22), and TQ+CP (TQ 10 mg/kg/day, oral gavage and CP 50 mg/kg, i.p. on days 1, 8, 15 and 22). After four weeks of applications, histopathological and biochemical analyzes were performed on heart tissues. Results: It was observed that CP caused a significant increase in malondialdehyde (MDA) levels in heart tissues (p
Açıklama
Anahtar Kelimeler
Cardiology, Kardiyoloji [EN] Systems Physiology, Sistem Fizyolojisi
Kaynak
Journal of Medical Topics and Updates
WoS Q Değeri
Scopus Q Değeri
Cilt
2
Sayı
3
