Effect of Altered Iron Metabolism on Hyperinflammation and Coagulopathy in Patients with Critical COVID-19: A Retrospective Study

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dc.contributor.authorOtlu, Önder
dc.contributor.authorErdem, Mehmet
dc.contributor.authorKorkmaz, Kübranur
dc.contributor.authorGünay, Özge Ota
dc.contributor.authorİn, Erdal
dc.contributor.authorKıran, Tuğba Raika
dc.contributor.authorBay Karabulut, Aysun
dc.date.accessioned2022-04-22T08:32:52Z
dc.date.available2022-04-22T08:32:52Z
dc.date.issued2022en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAbstract: A novel coronavirus disease 2019 (COVID-19) outbreak has started in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The relationship between altered iron homeostasis and hyperinflammation may be hallmarks of COVID-19 disease. We aimed to compare some iron (ferritin and iron), inflammation (C-reactive protein [CRP], hemoglobin, lactate dehydrogenase [LDH], neutrophil) and coagulation (prothrombin time [PT], activated partial thromboplastin time [APTT], D-dimer, platelet) marker results of critical COVID-19 patients with healthy controls results. In this single center retrospective study, 50 critical patients diagnosed with COVID-19 were included, demographic, clinical characteristics, severity of disease and laboratory test results were elicited from electronic medical records and compared to 50 healthy people. A statistically significant increase in CRP, LDH, neutrophil, PT, APTT, D-dimer ferritin levels was observed in critical COVID-19 patients compared with healthy people while a statistically significant decrease was observed in hemoglobin and iron levels. In addition, no statistically significant change in platelet levels was observed. Ferroptosis may be a significant cause of multiple organ failure in critical COVID-19 patients. Ferroptosis inhibitors might have potential to combat ferroptosis in COVID-19. Therefore, larger studies are needed to ferroptosis in COVID-19 in vivo and in vitro.en_US
dc.identifier.citationErdem, Ö. O. M., Korkmaz, K., Günay, Ö. O., İn, E., Kıran, T. R., & Karabulut, A. B. (2022). Effect of Altered Iron Metabolism on Hyperinflammation and Coagulopathy in Patients with Critical COVID-19: A Retrospective Study. Int J Acad Med Pharm, 4(1), 60-64.en_US
dc.identifier.doi10.29228/jamp.53918
dc.identifier.endpage64en_US
dc.identifier.issue1en_US
dc.identifier.startpage60en_US
dc.identifier.urihttp://dx.doi.org/10.29228/jamp.53918
dc.identifier.urihttps://hdl.handle.net/20.500.12899/1024
dc.identifier.volume4en_US
dc.institutionauthorOtlu, Önder
dc.institutionauthorErdem, Mehmet
dc.institutionauthorKorkmaz, Kübranur
dc.institutionauthorİn, Erdal
dc.institutionauthorKıran, Tuğba Raika
dc.institutionauthorBay Karabulut, Aysun
dc.language.isoenen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectFerroptosisen_US
dc.subjectHypercoagulabilityen_US
dc.subjectInflammationen_US
dc.subjectIronen_US
dc.subjectOxidative stressen_US
dc.titleEffect of Altered Iron Metabolism on Hyperinflammation and Coagulopathy in Patients with Critical COVID-19: A Retrospective Studyen_US
dc.typeArticleen_US

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