Biochemical effect evaluation of microbial chondroitin sulphate in experimental knee osteoarthritis model

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dc.authorid0000-0002-1786-5022en_US
dc.authorid0000-0002-7873-2805en_US
dc.authorid0000-0001-5958-7609en_US
dc.contributor.authorErenler, Ayse Şebnem
dc.contributor.authorBay Karabulut, Aysun
dc.contributor.authorSevimli, Resit
dc.contributor.authorGeçkil, Hikmet
dc.contributor.authorAkpolat, Nusret
dc.contributor.authorÜnver, Tuba
dc.contributor.authorOtlu, Önder
dc.date.accessioned2022-03-10T10:46:08Z
dc.date.available2022-03-10T10:46:08Z
dc.date.issued2022en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractOsteoarthritis (OA) is the most commonchronic joint disease, primarily due to aging.Chondroitin sulfate (CS) is a glycosaminoglycan(GAG) commonly used to treat osteoarthritis. CS candelay the progression of pathology or reversemorphological changes in joint structure.Traditionally CS is produced from animal sources.However, due to different reasons such ascontamination, ecological risA, and the possibility ofinfectious diseases, the trend towards microbialsources has increased because of its advantages suchas purer, more antiallergic, and lower MolecularWeight (MW) than animal sources. Biochemicalanalysis of Microbial CS (MCS), which is a new andsignificant alternative as a source of CS in the OAhealing process, has not been evaluated in theliterature yet. This study was designed to analyze thebiochemical effects of MCS produced by our teamfrom a microbial source, with an MW value of 269Daltons, on the osteoarthritis healing processcompared to the commercial form. We aim to reachdata that MCS has a higher antioxidant effect thananimalYsourced CS, and in this way, it is a moresuitable production for the treatment ofosteoarthritis. In this study, Anee osteoarthritis wassurgically induced in experimental rabbits; and TGFY1?, CAT, MPO, TOS, and OSI parameters measuredin blood samples before the operation and after thehealing period were analyzed comparatively. Afterthe surgical application, the rabbits were randomlydivided into three groups: control, animalYsourcedCS, and E. coli sourced MCS. The standard rabbitdiet was administered daily to 10 rabbits in Group 1(control), and CS and MCS were applied daily to theother groups as 17 mg/Ag for 12 weeAs. Bloodsamples were taAen from rabbits at the 12th weeAafter surgery, and TGFY1?, CAT, MPO, TOS, andOSI parameters were biochemically evaluated. Thisstudy has confirmed that the antioxidant propertiesof MCS and data on its effectiveness in controllingoxidative stress compared to animalYsourced CS.Based on these results, it can be concluded that MCShas a significant potency of nutraceutical andtherapeutic agents for OA treatment.en_US
dc.identifier.citationErenler, A. S., Karabulut, A. B., Sevimli, R., Geckil, H., Akpolat, N., Unver, T., & Otlu, O. (2022). BIOCHEMICAL EFFECT EVALUATION OF MICROBIAL CHONDROITIN SULPHATE IN EXPERIMENTAL KNEE OSTEOARTHRITIS MODEL. FRESENIUS ENVIRONMENTAL BULLETIN, 31(1), 510-+.en_US
dc.identifier.endpage517en_US
dc.identifier.issue1en_US
dc.identifier.startpage510en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12899/582
dc.identifier.volume31en_US
dc.institutionauthorErenler, Ayse Şebnem
dc.institutionauthorBay Karabulut, Aysun
dc.institutionauthorOtlu, Onder
dc.language.isoenen_US
dc.publisherErenler, Ayse Sebnem; Karabulut, Aysun Bay; Otlu, Onderen_US
dc.relation.ispartofFRESENIUS ENVIRONMENTAL BULLETINen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchondroitin sulphateen_US
dc.subjectmicrobial chondroitin sulphateen_US
dc.subjectosteoarthritisen_US
dc.titleBiochemical effect evaluation of microbial chondroitin sulphate in experimental knee osteoarthritis modelen_US
dc.typeArticleen_US

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