The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Yildirim, Engin
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Endometrial hyperplasia (EH) is considered an endometrial cancer precursor. This study aimed to determine the role of oxidative stress and thiol groups with antioxidant properties in EH pathogenesis. Materials and methods: In our prospective case-control study, participants were washed with 5 mL of saline before the endometrial biopsy. Endometrial washing fluid was taken into microtubules, and thiol and disulfide levels were analyzed using the Ellman reagent. Results: A total of 108 patients were in the EH group and 84 patients in the control group. The total and native thiol levels were higher values in the control group (p<0.001, for both). Disulfide levels were higher in the EH group (p<0.001). Native/total thiol ratio and disulfide/total thiol ratio were higher in the EH group (p<0.001, for both). The analysis performed in the control group revealed a significant positive correlation between estradiol and disulfide levels (r=0.322, p=0.033). No significant correlation was found between estradiol and disulfide in the EH group. Conclusion: Oxidative stress level was higher in the washing fluids of patients with EH and this stress plays a role in the EH etiology.
Açıklama
Anahtar Kelimeler
Endometrial hyperplasia, disulfide, oxidative stress, thiol
Kaynak
Turkish Society of Obstetrics and Gynecology
WoS Q Değeri
Scopus Q Değeri
Cilt
18
Sayı
4
Künye
Yıldırım, E., Türkler, C., Görkem, Ü., Şimşek, Ö. Y., Yılmaz, E., & Aladağ, H. (2021). The relationship between oxidative stress markers and endometrial hyperplasia: A case-control study. Turkish Journal of Obstetrics and Gynecology, 18(4), 298.
