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THE RELATIONSHIP BETWEEN SERUM ANGIOPOIETIN-LIKE PROTEIN 8 LEVELS AND HYPERTENSION STAGES
(2024) SARIOĞLU, Güney; aktaş, ibrahim
OBJECTIVE: Hypertension is a serious condition that can lead to serious complications. Currently, there is no standard biomarker used in clinical practice to diagnose hypertension and stage the disease. The aim of this study was to investigate whether serum levels of angiopoietin-like protein 8 (sANGPTL8) change in hypertensive patients and advanced stages of hypertension. MATERIAL AND METHODS: Our study is a prospective observational study. We used an ELISA kit to measure sANGPTL8 levels in 42 hypertensive patients and 41 healthy non-hypertensive patients at our cardiology clinic and evaluated statistical differences between the groups. A two-tailed p< 0.05 was considered statistically significant. RESULTS: The mean sANGPTL8 levels in the stage 2 hypertension group are statistically significantly higher than in the stage 1 and non-hypertensive group (813 pg/ml vs 524.89 pg/ml and 518.07 pg/ml respectively) (p= 0.001). CONCLUSIONS: According to our study, mean sANGPTL8 levels were higher in stage 2 hypertensive patients compared to stage 1 hypertensive and normotensive individuals (p=0.001). Additional biomarkers that can be used in combination with ANGPTL8 and further research on ANGPTL8 may enable this adipokine to be used as an effective biomarker in diagnosing advanced hypertension.