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    A comparison of the generation of free radicals in saliva of active and passive smokers
    (Tubitak Scientific & Technological Research Council Turkey, 2014) Demirtas, Murat; Senel, Unal; Yuksel, Sevda; Yuksel, Mustafa
    Aim: To reveal any correlation between cigarette smoke and malondialdehyde (MDA) values in the saliva fluid of subjects who are active smokers or nonsmoking subjects who are exposed to cigarette smoke in their environments. Materials and methods: Saliva samples were taken from 3 groups: a control group (group 1), a group inhaling smoke passively (group 2), and a test group (group 3) smoking 20 cigarettes per day; each group consisted of 20 members, giving a total sample of 60 people, aged 20 to 45 years. MDA, which is an indicator of lipid peroxidation, was measured via the colorimetric method. Results: Salivary MDA levels in smokers were found to be significantly higher compared to the control group and the group of passive smokers (P < 0.05). When compared with the control group, the MDA levels of passive smokers and active smokers were higher; when passive and active smokers were compared, the MDA levels of active smokers were higher. When all 3 groups were compared, the MDA levels in the control group (nonsmokers) were observed to be lower than the MDA level of the other 2 groups. Conclusion: It was observed that lipid peroxidation, which is an indicator used to determine oxidative stress, and MDA level, which is a product of this reactive chain, are significantly higher in individuals who are smokers. Such a high level of MDA in passive smokers indicates that smoking also affects nonsmokers negatively.
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    Malondialdehyde and nitric oxide levels and catalase, superoxide dismutase, and glutathione peroxidase levels in maternal blood during different trimesters of pregnancy and in the cord blood of newborns
    (Tubitak Scientific & Technological Research Council Turkey, 2015) Yuksel, Sevda; Yigit, Ayse Arzu
    Background/aim: To determine whether levels of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) change during the 3 trimesters of pregnancy, and to compare the third trimester of pregnancy with newborn cord blood in respect to the levels of MDA, NO, and antioxidant enzymes. Materials and methods: Maternal blood samples were collected at 9-13, 22-26, and 36-40 weeks of gestation. Cord blood was collected at the time of delivery. Results: NO levels and GPx activity were higher in the second and third trimesters than in the first trimester. MDA level was lower in the third trimester and SOD and CAT activities were lower in the second and third trimesters than the first trimester. In cord blood, MDA and NO levels were lower while CAT and GPx activities were higher than in the third trimester of pregnancy. Conclusion: These results suggest that the balance of free radical and antioxidant production during pregnancy ensures healthy fetus growth and development.
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    Oxidant and antioxidant status of human breast milk during lactation period
    (Springer France, 2015) Yuksel, Sevda; Yigit, Ayse Arzu; Cinar, Miyase; Atmaca, Nurgul; Onaran, Yuksel
    Due to the oxidative stress conditions at birth, newborn needs some immunological and antioxidative protection after birth. The present study was conducted to point out the oxidant and antioxidant activity of human breast milk throughout the lactation. For this purpose, the levels of malondialdehyde, nitric oxide, lactoferrin, superoxide dismutase, and catalase was determined in colostrum, transition milk, and mature milk. Milk samples were collected from 20 volunteer mothers at 24-48 h of delivery and 7 and 14 days after delivery. The skimmed milk was used for determination of the levels of malondialdehyde, nitric oxide, and lactoferrin and the activities of the catalase and superoxide dismutase enzymes. As the lactation period proceeded, the malondialdehyde level increased and the levels of nitric oxide and lactoferrin as well as the activities of catalase and superoxide dismutase decreased. Colostrum has a high antioxidant capacity, and these antioxidants decrease during the lactation period owing to the changing need of the growing infant. The results of this study revealed the importance of breastfeeding immediately after the birth to take the advantage of colostrum.
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    Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits
    (Churchill Livingstone, 2016) Akyol, Sumeyya; Yuksel, Sevda; Pehlivan, Sultan; Erdemli, Haci Kemal; Gulec, Mehmet Akif; Adam, Bahattin; Akyol, Omer
    Carbon monoxide poisoning is one of the important emergency situations manifested by primarily acute and chronic anoxic central nervous system (CNS) injuries and other organ damages. Current descriptions and therapeutic approaches have been focused on the anoxic pathophysiology. However, this point of view incompletely explains some of the outcomes and needs to be investigated extensively. Considering this, we propose that reactive oxygen species (ROS) including especially nitric oxide (NO) are likely to be a key concept to understand the emergency related to CO poisoning and to discover new therapeutic modalities in CO toxicity. If we consider the hypothesis that ROS is involved greatly in acute and chronic toxic effects of CO on CNS and some other vital organs such as heart, it follows that the antioxidant and anti-NO therapies might give the clinicians more opportunities to prevent deep CNS injury. In support of this, we review the subject in essence and summarize clinical and experimental studies that support a key role of ROS in the explanation of pathophysiology of CO toxicity as well as new treatment modalities after CO poisoning. (C) 2016 Elsevier Ltd. All rights reserved.
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    The consumption of propolis and royal jelly in preventing upper respiratory tract infections and as dietary supplementation in children
    (Scopemed, 2016) Yuksel, Sevda; Akyol, Sumeyya
    Propolis and royal jelly (RJ), two important honeybee products, have been used commonly all over the world as traditional and ethnopharmacological nutrients since ancient times. Both of them have a lot of active ingredients which are known to be effective for several medical conditions. In this article, medical databases were searched for the usage of RJ and propolis in upper respiratory tract infections (URTI) and as a dietary supplementation, together and separately. 10-hydroxy-2-decenoic acid is the most prominent active compound showing antimicrobial effect within RJ. Caffeic acid phenethyl ester is the most famous one that shows antimicrobial and anti-inflammatory effect within propolis. When compared with propolis, RJ was found to have richer content for all three main nutrients; proteins, carbohydrates, and lipids. More clinical, experimental, and basic studies are needed to find out the best standardized mixture to cope with URTI in which RJ and propolis will be main ingredients in addition to the other secondary compounds that have health-beneficial effects.
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    THE EFFECT OF DIFFERENT TURKISH SONG COMPOSITIONS ON THE SYMPATHIC AND IMMUNOBIOCHEMICAL PARAMETERS
    (Nobel Ilac, 2015) Yuksel, Sevda; Kazanci, Fatmanur Hacievliyagil; Ciftci, Sefa; Altan, Merve; Yuksel, Mustafa; Erdamar, Husamettin; Yigitoglu, Ramazan
    Objective: Turkey is a rich country in musical heritage. Studies on the use of music for therapeutic purposes are increasing day by day. The Greek philosophers were convinced that music benefited health and specific recommendations were formulated for using music therapeutically against mental and physical illness. To evaluate the effects of different classical Turkish music styles (Saba, Muhayyer Kurdi, Hijaz, Ussak) on these parameters. Therefore we planned this research to accomplish all of these aims. Material and Method: Venous blood samples were collected before and after music listening and serum levels of serotonin, adrenalin, immunoglobulin A and cortisol were measured. Sixtyone healthy volunteers listened five different kinds of music (popular, rock, arabesque, European classical, classical Turkish music). Results: To compare the same parameters in each volunteer before and after music listening, the Wilcoxon signed-ranks were performed as appropriate. For tests of significance, a p-value of <0.05 was considered to be statistically significant. All parameters were normally distributed. Conclusion: Our Statistical analysis results showed that cortisol level of the people listening Saba style decreased, Immunoglobulin A level decreased for the people who listened popular music and increased for the group listening Nihavent style and adrenaline level increased significantly in all groups except for the people listening Ussak style of music.
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    Wet Cupping (Hijamah) Increases Sleep Quality
    (Canadian Soc Clinical Investigation, 2015) Cikar, Selma; Ustundag, Gamze; Haciabdullahoglu, Seda; Yuksel, Sevda; Dane, Senol
    Purpose: Wet cupping (hijamah) therapy relieves the pain and relaxes the body. The research team aimed to examine the efficacy of wet cupping therapy on the sleep quality parameters in a healthy population. Methods: Participants were seventy-five healthy subjects (50 women, 25 men, median age = 29.61 years, SD = 8.92). Wet cupping was applied by a cupping practitioner. The assessment of the sleep quality parameters by Pittsburg Sleep Quality Index Inventory was applied one hour before and one month after wet cupping therapy. Results: All sleep quality parameters were positively affected after wet cupping therapy in healthy subjects. Conclusions: Wet cupping therapy should be considered as a complementary therapy method for people with sleep problems.