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Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women
(Tubitak Scientific & Technological Research Council Turkey, 2014) Kaygusuz, Ikbal; Simavli, Serap Aynur; Eser, Ayla; Inegol Gumus, Ilknur; Yuksel, Selcen; Iltemir Duvan, Zehra Candan; Kafali, Hasan
Background/aim: To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods: This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population. Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group. Conclusion: Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.