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    Autonomic Cardiac Activity in Patients with Smoking and Alcohol Addiction by Heart Rate Variability Analysis
    (Canadian Soc Clinical Investigation, 2016) Yuksel, Ramazan; Yuksel, Rabia Nazik; Sengezer, Tijen; Dane, Senol
    Purpose: Smoking and alcohol addictions are common and worldwide. In the present study, we aimed to investigate the effects of these addictions on cardiac rhythm using heart rate variability (HRV) analysis. Methods: Addicts (n=42 men: 22 cigarette; 20 cigarette and alcohol) and age-matched controls (n=34 men) were included in the study. All patients fulfill the criteria for dependence according to DSM-IV-TR. Electrocardiography (ECG) recordings were obtained for a total of 30 minutes. Fagerstrom Nicotine Addiction Test (FNAT) and CAGE questionnaire (Cut down, Annoy, Guilt, Eye opener) was applied to all patients. Results: Almost all HRV parameters were significantly decreased in cigarette and cigarette and alcohol addicts compared with controls (p<0.05). The mean heart rate (bpm) increased in both addict groups compared with control group, and this increase was particularly significant in cigarette and alcohol addicts. Conclusions: The cardiac autonomic balance shifted in favor of sympathetic activity by suppressing the parasympathetic activity in addicts; therefore, the present study shows that smoking and/or alcohol addiction leads to sympathetic activation and parasympathetic inhibition. Reduced vagal activity also predisposes to cardiac arrhythmias. This suggests an increased risk of cardiovascular mortality in subjects with smoking and alcohol addiction.
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    Effects of quercetin on methotrexate-induced nephrotoxicity in rats
    (Sage Publications Ltd, 2017) Yuksel, Yasemin; Yuksel, Ramazan; Yagmurca, Murat; Haltas, Hacer; Erdamar, Husamettin; Toktas, Muhsin; Ozcan, Osman
    Objective: This experimental study was conducted to elucidate the possible protective/therapeutic effects of quercetin against methotrexate (Mtx)-induced kidney toxicity with biochemical and histopathological studies. Methods: Twenty-four adult male rats were randomly divided into four groups, as follows: control group (saline intraperitoneally (i.p.), 9 days), Mtx group (20 mg/kg i.p., single dose), Mtx + quercetin group (50 mg/kg quercetin was orally administered 2 days before and 6 days after Mtx administration) and only quercetin group (50 mg/kg oral, 9 days). Structural changes were evaluated by hematoxylin-eosin and periodic acid-Schiff stainings. Apoptotic changes were investigated by terminal deoxynucleotidyl transferase dUTP nick end labeling assay and caspase-3 antibody. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were measured in tissue and plasma samples. Results: Mtx compared with the control group, there was significant increase in nephrotoxic tissue damage findings, in addition to apoptotic index (APOI) and caspase-3 expression (p < 0.05). Mtx + quercetin group revealed significantly lower histopathological damage and APOI and caspase-3 expression decreased when compared to Mtx group. MDA levels were increased in Mtx group compared to others, and by the use of quercetin, this increase was significantly reduced. SOD levels were higher in Mtx group than others. This increase was evaluated as a relative increase arising from oxidative damage caused by Mtx. Conclusion: As a result, Mtx administration may involve oxidative stress by causing structural and functional damage in kidney tissue in rats. Quercetin reduced the Mtx-induced oxidative stress through its antioxidant properties and so quercetin may be promising to alleviate Mtx-induced renal toxicity.
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    HEART RATE VARIABILITY DIFFERS BETWEEN RIGHT- AND LEFT-HANDED INDIVIDUALS
    (Ammons Scientific, Ltd, 2014) Yuksel, Ramazan; Arslan, Muzeyyen; Dane, Senol
    Previous studies reported reduced longevity in left-handers with the suggestion that it may be associated with different heart diseases. Therefore, differences in heart rate variability (HRV), an index of autonomic cardiac activity, were examined for right-and left-handed individuals. 120 healthy young university students (75 women, 45 men; M age = 20.4 yr., SD = 1.5) volunteered. Handedness was assessed with the Edinburgh Handedness Inventory and HRV was measured via electrocardiography. The results suggest that the left-handers' HRV was significantly different from that of right-handers on several parameters. The atypical cerebral organization of left-handers may be related to an imbalanced autonomic system that results in higher frequencies of heart irregularities.
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    Left-right asymmetry in neck lymph nodes distribution in patients with bilateral laryngeal cancer
    (Springer France, 2014) Yoruk, Ozgur; Yuksel, Ramazan; Yuksel, Yasemin; Dane, Senol
    We aimed to examine left-right asymmetry in involved and total neck lymph nodes distribution in patients with bilateral laryngeal cancer in the present study. Forty-six patients with bilateral laryngeal cancer was included the study. The oncologic database of our otorhinolaryngology department was used. The right and left lymph node with and without involvement by cancer cells counts were retrieved from pathological reports. The numbers of both involved and total neck lymph nodes were significantly higher on right side than on left side for all neck levels in laryngeal malignancies. The results of the present study suggest the existence of a left-right asymmetry in neck lymph node distribution and in the neck lymph node distribution involved by laryngeal cancer cells. The stronger cell-mediated immune activity in the left side of humans may be associated with the blocking of the metastatic invasion of cancer cells from laryngeal malignancies in the left body side.
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    Olive Oil and Health: Bioactive Constituents, Antioxidant Properties and Clinical Implications
    (Duzce Univ, 2013) Armutcu, Ferah; Namuslu, Mehmet; Yuksel, Ramazan; Kaya, Mehmet
    Mediterranean countries have lower rates of mortality from cardiovascular disease and cancer than other European countries. Olive oil is the major source of dietary fat in the Mediterranean diet, and its regular consumption is thought to have various beneficial effects on human health. The biological features ascribed to olive oil consumption are associated in part to its phenolics constituents, and mainly linked to the direct or indirect antioxidant activity of olive oil phenolics and other components such as oleic acid and squalene. The major phenolic compounds identified and quantified in olive oil belong to three groups which all of them have potent antioxidant properties; simple phenols (hydroxytyrosol, tyrosol), secoiridoids (oleuropein) and the lignans. Among these substances the last two classes include the most concentrate phenols of virgin olive oil. As observed in traditional Mediterranean populations, it has been confirmed that extra virgin olive oil is beneficial when consumed properly. Many evidence indicates, however, that olive oil and its components contribute significantly to the health benefits of the Mediterranean diet, with more of an effect on prevention than treatment. This paper summarizes the evidence supporting the potentially beneficial effects of olive oil phenolics and other bioactive components.
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    The effect of sleep deprivation on heart rate variability in shift and non-shift physicians
    (Canadian Soc Clinical Investigation, 2015) Cebeci, Sevsen; Canbal, Metin; Yuksel, Ramazan; Cetin, Medine; Caliskan, Yasemin; Dane, Senol
    Purpose: Higher LF/HF ratio and lower heart rate variability have been reported among shift compared with non-shift workers. We aimed to investigate the possible harmful effects of sleep deprivation on cardiac rhythm, specifically heart rate variability (HRV), in work shift physicians. Patients and Methods: Eighty seven healthy male physicians participated in this study. The present study was done in Ankara, Turkey, from January to September 2014. Work shift (sleep deprivation) group (n=45) remained awake for 26 h. Non-work shift group slept in their homes. ECG (HRV) was applied at 9 am for both shift and non-shift groups. Results: Almost all HRV parameters, except LF/HF, decreased in the work shift group compared with the non-shift group. Conclusions: Sleep deprivation due to work shift may cause sympathovagal imbalances by affecting the biological rhythm.
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    Wet Cupping Therapy Restores Sympathovagal Imbalances in Cardiac Rhythm
    (Mary Ann Liebert, Inc, 2014) Arslan, Muzeyyen; Yesilcam, Nesibe; Aydin, Duygu; Yuksel, Ramazan; Dane, Senol
    Objectives: A recent study showed that cupping had therapeutic effects in rats with myocardial infarction and cardiac arrhythmias. The current studyaimed to investigate the possible useful effects of cupping therapy on cardiac rhythm in terms of heart rate variability (HRV). Materials and methods: Forty healthy participants were included. Classic wet cupping therapy was applied on five points of the back. Recording electrocardiography (to determine HRV) was applied 1 hour before and 1 hour after cupping therapy. Results: All HRV parameters increased after cupping therapy compared with before cupping therapy in healthy persons. Conclusions: These results indicate for the first time in humans that cupping might be cardioprotective. In this study, cupping therapy restored sympathovagal imbalances by stimulating the peripheral nervous system.