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    A Little-Known Subject: Lead and Cardiac Toxicity
    (Elsevier Science Inc, 2013) Demircelik, Muhammed Bora; Yilmaz, Omer Caglar; Yilmaz, Hinc; Tutkun, Engin; Gurel, Ozgul Malcok; Atar, Inci Asli; Cetin, Zehra Guven
    [Abstract Not Available]
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    Association between Red Blood Cell Distribution Width and Coronary Artery Calcification in Patients Undergoing 64-Multidetector Computed Tomography
    (Korean Soc Cardiology, 2015) Gurel, Ozgul Malcok; Demircelik, Muhammed Bora; Bilgic, Mukadder Ayse; Yilmaz, Hakki; Yilmaz, Omer Caglar; Cakmak, Muzaffer; Eryonucu, Beyhan
    Background and Objectives: The red blood cell distribution width (RDW) has been found to be associated with cardiovascular morbidity and mortality. The objective of this study was to determine whether the RDW measures are associated with the coronary artery calcification score (CACS) in patients who did not present with obvious coronary heart disease (CHD). Subjects and Methods: A total of 527 consecutive patients with a low to intermediate risk for CHD but without obvious disease were enrolled in this study. The study subjects underwent coronary computerized tomography angiography and CACS was calculated. The patients were divided into two groups based on CACS: Group I (CACS <= 100) and Group II (CACS>100). The two groups were compared in terms of classic CHD risk factors and haematological parameters, particularly the RDW. Results: Group I patients were younger than Group II patients. The Framingham risk score (FRS) in patients of Group II was significantly higher than that in patients of Group I. Group II patients had significantly elevated levels of haemoglobin, RDW, neutrophil count, and neutrophil/lymphocyte ratio compared with Group I patients. CACS was correlated with age, RDW, and ejection fraction. In the multivariate analysis, age, RDW, and FRS were independent predictors of CACS. Using the receiver-operating characteristic curve analysis, a RDW value of 13.05% was identified as the best cut-off for predicting the severity of CACS (>100) (area under the curve=0.706). Conclusion: We found that the RDW is an independent predictor of the CACS, suggesting that it might be a useful marker for predicting CAD.
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    Association of Red Blood Cell Distribution Width with Coronary Artery Calcification
    (Elsevier Science Inc, 2013) Gurel, Ozgul Malcok; Bilgic, Ayse; Demircelik, Bora; Gunes, Mahmut; Yilmaz, Omer Caglar; Bozduman, Fadime; Kahyalar, Kemal
    [Abstract Not Available]
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    Epicardial adipose tissue and pericoronary fat thickness measured with 64-multidetector computed tomography: potential predictors of the severity of coronary artery disease
    (Hospital Clinicas, Univ Sao Paulo, 2014) Demircelik, Muhammed Bora; Yilmaz, Omer Caglar; Gurel, Ozgul Malcok; Selcoki, Yusuf; Atar, Inci Asli; Bozkurt, Alper; Akin, Kayihan
    OBJECTIVE: The aim of the present study was to investigate the relationship between pericoronary fat and the severity and extent of atherosclerosis, quantified using 64-multidetector computed tomography, in patients with suspected coronary artery disease. METHODS: The study population consisted of 131 patients who were clinically referred for noninvasive multislice computed tomography coronary angiography for the evaluation of coronary artery disease. Patients were classified as follows: no atherosclerosis, Group 1; nonobstructive atherosclerosis (luminal narrowing <50% in diameter), Group 2; and obstructive atherosclerosis (luminal narrowing >= 50%) in a single vessel or obstructive atherosclerosis in the left main coronary artery and/or multiple vessels, Group 3. Epicardial adipose tissue was defined as the adipose tissue between the surface of the heart and the visceral layer of the pericardium (visceral epicardium). Epicardial adipose tissue thickness (mm) was determined in the right ventricular anterior free wall. The mean thickness of the pericoronary fat surrounding the three coronary arteries was used for the analyses. RESULTS: The average thickness over all three regions was 13.2 +/- 2.1 mm. The pericoronary fat thickness was significantly increased in Group 3 compared with Groups 2 and 1. The epicardial adipose tissue thickness was significantly increased in Group 3 compared with Groups 2 and 1. A receiver operating characteristic curve for obstructive coronary artery disease was assessed to verify the optimum cut-off point for pericoronary fat thickness, which was 13.8 mm. A receiver operating characteristic curve for obstructive coronary artery disease was also assessed to verify the optimum cut-off point for epicardial adipose tissue, which was 6.8 cm. CONCLUSION: We showed that the epicardial adipose tissue and pericoronary fat thickness scores were higher in patients with obstructive coronary artery diseases.
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    Geniş hasta popülasyonunda çok kesitli bilgisayarlı tomografik anjiyografi ile saptanan miyokardiyal köprü prevelansı
    (2014) GÜVEN, Abdullah; Yilmaz, Omer Caglar; SELÇOKİ, Yusuf; DEMİRÇELİK, Muhammed Bora; MALÇOK, Özgür Gürel
    Amaç: Göğüs ağrısı ile başvuran 1696 hastada Multi-dedektör bilgisayarlı tomografi (MDCT) ile miyokardiyal köprüinsidansını saptamakMateryal ve Metot: Temmuz 2007 ile Ocak 2010 arasında koroner arter hastalığı ön tanısı ile veya postoperatif koroner bypass cerrahisi geçiren ya da stent takılangöğüs ağrısı olan 1696 sıralı hasta çalışmaya alındı. Kalphızı dakikada 65 atım üzeri olan hastalara işlemden 1saat önce 50-100 mg oral metoprolol süksinat veya 2,5-5 mg iv metoprolol verildi. BT koroner anjiyografi 64 kesitli MDCT ile uygulandı. Hasta bilgilerini bilmeyen birradyolog tarafından görüntüler değerlendirildi. Klinikkorelasyon miyokardiyal köprü varlığına göre uygulandı.Bulgular: 1696 hastanın 198inde (%11,6) miyokardiyalköprü saptandı ve bunların 167sinde (%84) köprü solanteriyor inen arter (LAD)nin orta 1/3lük kısmında, 13ünde (%6,5), proksimal 1/3ünde, 15inde (%7,5) distal1/3ünde, 1inde obtus marjin (OM) de, 2sinde (%1)RCAda saptandı. Tünel arterin uzunluğu 5 ile 50 mm(ortanca 20,3 mm) arası hesaplandı. Köprüsü olan 12hastada göğüs ağrısının nedeninin miyokardiyal köprü ileilişkili olduğu düşünüldü. Diğer 186 hastada ise göğüsağrısının başka nedenleri mevcuttu.Sonuçlar: Miyokardiyal köprü insidansını %11,6 olarakbulduk. Göğüs ağrısı olan bir hastada miyokardiyal köprübir sebep olabilir. MDCT miyokardiyal köprüyü saptamada faydalı bir tanısal araç olabilir.