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Öğe Evaluation of arterial stiffness in patients with generalized anxiety disorder(2023) Yildiz, Sevler; Kılıçaslan, Aslı Kazğan; Uğur, Kerim; kurt, osman; KILIÇARSLAN, GÜLHANPurpose: Generalized anxiety disorder (GAD) is a psychiatric condition where both physical and mental symptoms are observed due to the activation of the sympathetic system. It is known that the disorder affects the cardiovascular system. The present study aimed to analyze arterial stiffness in GAD patients and compare the findings with healthy controls. Materials and Methods: 40 patients diagnosed with GAD and 40 healthy individuals were included in the study. Carotid and femoral artery intima-medial thickness (IMT) and arterial thickness parameters were measured with Doppler ultrasonography. Results: The femoral IMT of the patients was significantly low. Although the carotid IMT was higher in patients when compared to the controls, the difference was not statistically significant. A significant negative correlation was determined between fluoxetine equivalent dose and femoral IMT. There was a correlation between femoral IMT and fluoxetine equivalent dose. Conclusion: Arterial stiffness should be investigated for its potential to indicate cardiovascular risk in GAD. Further comprehensive studies should be conducted to clarify whether atherosclerosis symptoms were associated with the nature of the GAD or prescription medicine.Öğe Evaluation of Optical Coherence Tomography Findings in Antisocial Personality Disorder Patients(Aves, 2023) Emir, Burcu Sirlier; Yildiz, Sevler; Kilicaslan, Asli Kazgan; Kurt, Osman; Keser, Sinem; Ugur, KerimBackground: Antisocial personality disorder is a frequently studied personality disorder, and its etiopathogenesis is still investigated. Neuroimaging demonstrated that certain regions of the brain could be associated with this disorder, and in the present study, we aimed to investigate the changes in retina, which could be considered an extension of the brain in antisocial personality disorder patients with optical coherence tomography. Methods: The study was conducted with 35 patients and 35 healthy controls. The study data were collected with the Sociodemographic and Clinical Data Form, Beck Anxiety Inventory, Beck Depression Inventory, and Barratt Impulsivity Scale-Short Form. Retinal nerve fiber layer thickness, choroidal thickness, and macular thickness were analyzed based on optical coherence tomography. Results: The Beck Depression Inventory (P =.044), Beck Anxiety Inventory (P =.005), Barratt Impulsivity Scale-motor (P <.001), Barratt Impulsivity Scale-non-planning dimension (P <.001), and Barratt Impulsivity Scale-total scores (P <.001) of the patients were significantly higher when compared to the controls. The superior (P =.013) and inferior retinal nerve fiber layer thickness (P <.001) of the patients were significantly lower when compared to the control group. Conclusion: Retinal nerve fiber layer thickness was significantly lower in the patient group when compared to healthy controls, which suggested that it could be associated with the pathophysiology of antisocial personality disorder.Öğe Inflammation Markers in Patients with Bipolar Disorder Who Have Committed Offenses and Their Relationship with Criminal Behavior(Mdpi, 2023) Sirlier Emir, Burcu; Yildiz, Sevler; Kazgan Kilicaslan, Asli; Kurt, Osman; Ugur, Kerim; Tabara, Muhammed Fatih; Aydin, SueleymanBackground and Objectives: This study aimed to examine the function of various inflammation parameters and their interactions in the pathology of Bipolar disorder (BD) and to assess whether they could be biomarkers in the relationship between criminal behavior and BD. Materials and Methods: Overall, 1029 participants, including 343 patients with BD who have committed offenses, 343 nonoffending patients with BD, and 343 healthy controls, were included in this retrospective study. Neutrophil, lymphocyte, monocyte, and platelet counts; high-density lipoprotein (HDL-c) levels; systemic immune-inflammatory index (SII), systemic inflammatory response index (SIRI), neutrophil to high-density lipoprotein ratio (NHR), lymphocyte to high-density lipoprotein ratio (LHR), monocyte to high-density lipoprotein ratio (MHR), platelet to high-density lipoprotein ratio (PHR) were measured. Results: Significant differences were observed between the groups in terms of SII, SIRI, NHR, LHR, MHR, PHR, neutrophil, and monocyte values (p < 0.001). The lymphocyte counts were significantly higher in the patients with BD who committed offenses (p = 0.04). The platelet counts were significantly lower in the patients with BD who committed offenses compared to nonoffending patients with BD (p = 0.015). The HDL-c levels were significantly lower in the patients with BD who have committed offenses than those of nonoffending patients with BD (p < 0.001). Bipolar disorder, not receiving active psychiatric treatment, having a diagnosis of bipolar manic episodes, and having low platelet and HDL values constitute a risk of involvement in crime. Conclusions: The present study emphasizes the role of systemic inflammation in the pathophysiology of patients with BD with and without criminal offenses and the relationship between inflammation and criminal behavior.Öğe Inflammation markers in patients with psychotic disorder who have committed offenses and their relationship with criminal behavior(Routledge Journals, Taylor & Francis Ltd, 2025) Yildiz, Sevler; Emir, Burcu Sirlier; Kilicaslan, Asli Kazgan; Kurt, Osman; Ugur, Kerim; Sehlikoglu, Seyma; Atmaca, MuradThe role of inflammation in the etiology of psychotic disorders (PD) is well-established. This study aimed to identify inflammation parameters in patients diagnosed with PD, assess their potential as biomarkers, and examine their relationship with criminal behavior. This retrospective study comprised three groups: 530 patients diagnosed with PD who had committed crimes (offenders with PD), 530 patients with PD who had not committed crimes (non-offenders with PD), and 530 healthy controls, totaling 1,590 participants. Routine hematological tests were used to measure neutrophil, lymphocyte, monocyte, and platelet counts, high-density lipoprotein (HDL), systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), and neutrophil/HDL (NHR), lymphocyte/HDL, platelet/HDL (PHR), and monocyte/HDL (MHR) ratios. Offenders with PD exhibited significantly higher levels of SII, SIRI, PHR, NHR, LHR, neutrophils, and monocytes compared to non-offenders with PD and healthy controls (p < 0.001). The criminal group had lower HDL and lymphocyte levels than the remaining two groups (p < 0.001). Among those treated in forensic psychiatry units, patients with two or more treatments showed significantly higher SIRI values compared to those with only one treatment (p = 0.045). Non-offenders with PD had higher platelet values than the remaining two groups (p < 0.001). This study underscores the role of systemic inflammation in the pathophysiology of psychotic disorders through a comparison of patients who have and have not committed crimes, highlighting the relationship between inflammation and lipid metabolism. Further research is required to clarify these findings.Öğe Markers of inflammation in patients with generalized anxiety disorder(2024) Yildiz, Sevler; Kılıçaslan, Aslı Kazğan; Emir, Burcu Sırlıer; TABARA, Muhammed Fatih; kurt, osman; SEHLİKOĞLU, ŞEYMA; Uğur, KerimPurpose: The aim of this study was to analyze the systemic immune response index, systemic immune inflammation index, neutrophil/HDL, lymphocyte/HDL, platelet/HDL, and monocyte/HDL ratio, used as inflammatory markers in patients with generalized anxiety disorder (GAD). Materials and Methods: A total of 864 participants, including 432 healthy controls and 432 patients diagnosed with GAD, were included in this study. High-density lipoprotein (HDL-c) levels, neutrophil, monocyte, lymphocyte, and platelet counts; systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), neutrophil/high-density lipoprotein ratio (NHR), lymphocyte/high-density lipoprotein ratio (LHR), monocyte/high-density lipoprotein ratio (MHR), and platelet/high-density lipoprotein ratio (PHR) were calculated. Results: The median age of the case group was 35.50 (interquartile range: 28.00-44.00), while the median age of the control group was 35.00 (interquartile range: 28.00-44.00). In the GAD group, neutrophils, monocytes, SII, SIRI, NHR, LHR, MHR, and PHR were significantly higher, while platelets and HDL were significantly lower. Conclusions: This study highlights that elevated systemic inflammation markers, such as SII and SIRI, along with altered HDL ratios, may be associated with GAD. The findings support the hypothesis that inflammation plays a role in the etiopathogenesis of GAD, potentially contributing to both diagnosis and management.Öğe Methods of Coping With Psychological Pain and Stress in Antisocial Personality Disorder(2023) Emir, Burcu Sırlıer; Yildiz, Sevler; Kılıçaslan, Aslı Kazğan; SEHLİKOĞLU, ŞEYMA; kurt, osman; Uğur, KerimAim: Antisocial Personality Disorder (ASPD) is a personality dis - order in which the person has difficulty controlling his behaviors and impulses, harming both himself and his environment. In our study, we aimed to examine the psychological pain experienced by people with ASPD and the methods of coping with the stress they use to combat it. Material and Method: Forty patients and 40 healthy control groups were included in the study. Sociodemographic Data Form, Beck Depression Scale (BDI), Beck Suicide Scale (BSS), Psychache Scale (PS), and Styles of Coping with Stress (SCSS) were administered to the participants. Results: The BDI (p=0.037), BSS (p=0.009), PS (p=0.008) and SCSS-helpless approach (p=0.01) scores of the patients in the pa - tient group were significantly higher than the scores of the control group. On the other hand, the scores of SCSS-self-confident ap - proach (p=0.001) and SCSS-searching for social support (p<0.001) were found to be significantly lower than the scores of the control group. In the patient group, there was a positive correlation between BDI and BSS, PS and SCSS-optimistic approach. On the other hand, there was a significant negative correlation between BDI and SCSS-self-confident approach and SCSS-seeking social support Conclusion: In our study, depression, suicide, and psychological pain were found to be significantly higher in people with ASPD compared to the control group, and it was determined that they used ineffective coping strategies. We think that early interventions for the treatment of psychological pain, such as suicidal ideation, determination of depression, and providing support for using ef - fective coping strategies, may be effective in preventing self-de - structive behaviors or suicides in ASPD, and therefore may change the course of the disease.Öğe Resilience, depression and burnout levels in caregivers of patients followed in the forensic psychiatry service(2023) Yildiz, Sevler; Kılıçaslan, Aslı Kazğan; Emir, Burcu Sırlıer; kurt, osman; Uğur, KerimObjective: It is known that psychiatric diseases also affect the quality of life of patients' relatives. The aim of this study is to examine the level of resilience, depression and burnout of the caregivers of forensic psychiatry patients in order to recognize the mental problems that may be experienced by relatives of forensic psychiatry patients who have com- mitted crimes in addition to psychiatric illness. Method: 90 high-security forensic psychiatry patient relatives were included in the study. Sociodemographic data form, Beck Depression Inventory (BDI), Adult Resilience Scale (RSA) and Maslach Burnout Inventory (MBI) were admi- nistered to all participants. Results: BDI score of caregivers was 10.8±7.7, RSA-total 99.8±12.5, emotional burnout score from MBI subscales 22.5±3.4, depersonalization score 9.4±2.2, personal success score was determined as 16.8±5.4. There was a signifi- cant difference between the duration of caregiving in terms of BDI score (p<0.01). The BDI score of the caregivers of the patients with criminal liability was found to be significantly higher than the score of the caregivers of the patients without criminal liability (p< 0.01). Discussion: It was observed that the level of psychological resilience was good in people who took care of psychiatric patients who were subjected to forensic psychiatric examination, but they had mild depression and moderate burnout. It is seen that the relatives of the patients are affected psychologically and the necessary psychosocial support can be positive for the caregivers.Öğe Şizofreni Tanılı Hastalarda Serum HMGB1 ve Beklin 1 Düzeyleri(2024) Yildiz, Sevler; Kılıçaslan, Aslı Kazğan; Emir, Burcu Sırlıer; Uğur, Kerim; KILIC, FARUKAmaç: Şizofreni etiyopatogenezinde inflamasyonun rol oynadığı bilinmektedir. Bu çalışmada şizofreni tanılı hastalarda yüksek mobilite grup kutusu 1 protein (HMGB1) ve Beklin 1 seviyeleri ile klinik değişkenler arasındaki ilişki incelenmiştir. Metod: Çalışmaya 43 şizofreni hastası ve 43 sağlıklı kontrol grubu dahil edildi. Tüm katılımcılara sosyodemografik veri formu, Pozitif Negatif Semptom Skalası (PANSS), Klinik Global İzlem Ölçeği (CGI) uygulandı. Ölçekler doldurulduktan sonra hem hasta hem de kontrol grubundan serum HMGB1 ve Beklin 1 seviyelerini ölçmek için venöz kan örneği alındı. Santrifüj sonunda elde edilen serum örnekleri Enzyme-Linked ImmunoSorbent Assay (ELISA) yöntemi ile ölçüldü. Bulgular: Şizofreni hastalarında serum HMGB1 seviyesi kontrol grubuna göre anlamlı düzeyde yüksek saptandı. Serum Beklin 1 seviyeleri ise hasta grubunda kontrol grubuna göre anlamlı düzeyde düşük olarak bulundu. Ayrıca HMGB1 ve Beklin-1 düzeyleri arasında negatif ilişki tespit edildi. Sonuç: Sonuç olarak, mevcut araştırma şizofreni olan hastalarda HMGB1’in arttığını, Beklin 1’in azaldığını ve bu bulguların şizofreni patogenezinde otofajinin rolüne katkıda bulunabileceğini göstermektedir.
