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    Causes of high erythrocyte sedimentation rates in elderly patients
    (2013) Uğuz, Nihal; Çelik, Hüseyin Tuğrul; Torun-Güngör, Oya; Bal, Ceylan Demir; Bakır, Fatih; Kazanci, Fatma; Yiğitoğlu, Ramazan
    Objective: The erythrocyte sedimentation rate (ESR) determination is a simple and inexpensive laboratory test that is frequently ordered in clinical medicine. The test measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. In this study it was aimed to determine the frequency of diseases which ESRs were over 100 mm/h in patients aged 65 and over. Method: In this study patients aged 65 and over who were treated in Turgut Özal University Hospital were retrospectively examined. Patients whose ESRs were over 100 mm/h were analyzed recording their ages, genders, ESRs and diagnoses. Diagnoses were divided into five groups: (i) infection; (ii) malignancy; (iii) inflammatory/connective tissue diseases; (iv) renal diseases; (v) miscellaneous diseases. Results: Two hundred five patients aged 65 and over whose ESRs were over 100 mm/h were analyzed. 115 of patients were women (56%) and 90 of them were men (44%). Age means of patients were 74.9 ± 6.45 and ESR means were 114.9 ± 14.8. When distribution according to disease groups was assessed, infection took the first rank (37.5%), malignancy took the second rank (21.9%), miscellaneous diseases took the third rank (21.4%), renal diseases took the forth rank (15.1%). The frequency of inflammatory/connective tissue diseases was 3.9%. Conclusion: In elderly, the most common cause of extreme elevation of ESR is infection. Different from other age groups, malignancy was found as the second common reason causing elevation of ESR. When etiology was researched in patients with extreme elevation of ESR, the age factor must be taken into consideration. © 2013 Elsevier B.V., All rights reserved.
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    Endothelin-1 and Nitric Oxide levels in exudative age-related macular degeneration
    (Wolters Kluwer Medknow Publications journal@jovr.org, 2015) Totan, Yüksel; Koca, Cemile; Erdurmuş, Mesut; Keskin, Uğurcan; Yiğitoğlu, Ramazan
    Purpose: To evaluate plasma levels of endothelin-1 (ET-1) and nitric oxide (NO) in patients with exudative age-related macular degeneration (AMD). Methods: In this study, ET-1 levels, as well as nitrite plus nitrate concentrations as an indicator of plasma NO level, were measured in the plasma of 20 subjects with exudative AMD and compared with 20 healthy age and sex matched controls. Results: Mean plasma ET-1 level was significantly higher in exudative AMD patients as compared to control subjects (0.35 ± 0.06 fmol/ml versus 0.17 ± 0.03 fmol/ml, P = 0.015). Patients with exudative AMD also showed significantly lower mean plasma levels of nitrite plus nitrate as compared to the controls (58.9 ± 2.7 ?mol/l versus 82.6 ± 5.9 ?mol/l, P = 0.001). Conclusion: Increased concentrations of ET-1 and reduced levels of NO in the plasma may suggest an imbalance between vasoconstrictor and vasodilator agents, respectively, as a reflection of endothelial dysfunction in the pathogenesis of AMD. These findings may also imply the role of vasoconstriction in exudative AMD. © 2020 Elsevier B.V., All rights reserved.
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    The effect of different turkish song compositions on the sympathic and immunobiochemical parameters
    (Nobelmedicus Inkilap Mah. Akcakoca Sok. No: 10 Umraniye Istanbul 34768, 2015) Yüksel, Sevda; Kazancı, Fatmanur Hacıevliyagil; Çiftçi, Sefa; Altan, Merve; Yüksel, Mustafa T.; Erdamar, Hüsamettin; Yiğitoğlu, Ramazan
    Objective: Turkey is a rich country in musical heritage. Studies on the use of music for therapeutic purposes are increasing day by day. The Greek philosophers were convinced that music benefited health and specific recommendations were formulated for using music therapeutically against mental and physical illness. To evaluate the effects of different classical Turkish music styles (Saba, Muhayyer Kurdi, Hijaz, Ussak) on these parameters. Therefore we planned this research to accomplish all of these aims. Material and Method: Venous blood samples were collected before and after music listening and serum levels of serotonin, adrenalin, immunoglobulin A and cortisol were measured. Sixtyone healthy volunteers listened five different kinds of music (popular, rock, arabesque, European classical, classical Turkish music). Results: To compare the same parameters in each volunteer before and after music listening, the Wilcoxon signed-ranks were performed as appropriate. For tests of significance, a p-value of <0.05 was considered to be statistically significant. All parameters were normally distributed. Conclusion: Our Statistical analysis results showed that cortisol level of the people listening Saba style decreased, Immunoglobulin A level decreased for the people who listened popular music and increased for the group listening Nihavent style and adrenaline level increased significantly in all groups except for the people listening Ussak style of music. © 2016 Elsevier B.V., All rights reserved.