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Öğe Association between attention deficit hyperactivity disorder and chronotype in adults with epilepsy(Cukurova Univ, Fac Medicine, 2025) Ugur, Kerim; Sun, Tunahan; Tasci, Irem; Kartal, FatmaPurpose: This study aimed to determine the chronotype characteristics in adults with epilepsy, examine the relationship between chronotype and Attention Deficit Hyperactivity Disorder (ADHD), and compare ADHD symptom levels between patients with epilepsy and healthy controls. Materials and Methods: The study included 90 patients with epilepsy and 70 healthy controls, aged between 18 and 65 years. Sociodemographic and clinical data (seizure status, EEG, and MRI findings) were collected from the participants. The Morningness-Eveningness Questionnaire (MEQ), Adult ADHD Diagnosis and Evaluation Inventory, and Adult ADHD Self-Report Scale (ASRS) were administered. Results: A higher proportion of intermediate chronotypes was observed in the epilepsy group (68.9%) than in the control group (51.4%). ADHD symptom scores were higher in patients than in controls. Among patients with epilepsy, individuals with intermediate and evening chronotypes had significantly higher ADHD symptoms than those with morning chronotype. Although individuals with an evening chronotype had higher ADHD symptom levels than those with an intermediate chronotype, this difference was not statistically significant. Conclusion: The findings suggest that ADHD symptoms become more pronounced in patients with epilepsy as chronotype characteristics shift toward eveningness. Circadian features should be considered in the evaluation and management of ADHD comorbidity in adult patients with epilepsy.Öğe Evaluation of Optical Coherence Tomography Findings in Antisocial Personality Disorder Patients(Aves, 2023) Emir, Burcu Sirlier; Yildiz, Sevler; Kilicaslan, Asli Kazgan; Kurt, Osman; Keser, Sinem; Ugur, KerimBackground: Antisocial personality disorder is a frequently studied personality disorder, and its etiopathogenesis is still investigated. Neuroimaging demonstrated that certain regions of the brain could be associated with this disorder, and in the present study, we aimed to investigate the changes in retina, which could be considered an extension of the brain in antisocial personality disorder patients with optical coherence tomography. Methods: The study was conducted with 35 patients and 35 healthy controls. The study data were collected with the Sociodemographic and Clinical Data Form, Beck Anxiety Inventory, Beck Depression Inventory, and Barratt Impulsivity Scale-Short Form. Retinal nerve fiber layer thickness, choroidal thickness, and macular thickness were analyzed based on optical coherence tomography. Results: The Beck Depression Inventory (P =.044), Beck Anxiety Inventory (P =.005), Barratt Impulsivity Scale-motor (P <.001), Barratt Impulsivity Scale-non-planning dimension (P <.001), and Barratt Impulsivity Scale-total scores (P <.001) of the patients were significantly higher when compared to the controls. The superior (P =.013) and inferior retinal nerve fiber layer thickness (P <.001) of the patients were significantly lower when compared to the control group. Conclusion: Retinal nerve fiber layer thickness was significantly lower in the patient group when compared to healthy controls, which suggested that it could be associated with the pathophysiology of antisocial personality disorder.Öğe Inflammation Markers in Patients with Bipolar Disorder Who Have Committed Offenses and Their Relationship with Criminal Behavior(Mdpi, 2023) Sirlier Emir, Burcu; Yildiz, Sevler; Kazgan Kilicaslan, Asli; Kurt, Osman; Ugur, Kerim; Tabara, Muhammed Fatih; Aydin, SueleymanBackground and Objectives: This study aimed to examine the function of various inflammation parameters and their interactions in the pathology of Bipolar disorder (BD) and to assess whether they could be biomarkers in the relationship between criminal behavior and BD. Materials and Methods: Overall, 1029 participants, including 343 patients with BD who have committed offenses, 343 nonoffending patients with BD, and 343 healthy controls, were included in this retrospective study. Neutrophil, lymphocyte, monocyte, and platelet counts; high-density lipoprotein (HDL-c) levels; systemic immune-inflammatory index (SII), systemic inflammatory response index (SIRI), neutrophil to high-density lipoprotein ratio (NHR), lymphocyte to high-density lipoprotein ratio (LHR), monocyte to high-density lipoprotein ratio (MHR), platelet to high-density lipoprotein ratio (PHR) were measured. Results: Significant differences were observed between the groups in terms of SII, SIRI, NHR, LHR, MHR, PHR, neutrophil, and monocyte values (p < 0.001). The lymphocyte counts were significantly higher in the patients with BD who committed offenses (p = 0.04). The platelet counts were significantly lower in the patients with BD who committed offenses compared to nonoffending patients with BD (p = 0.015). The HDL-c levels were significantly lower in the patients with BD who have committed offenses than those of nonoffending patients with BD (p < 0.001). Bipolar disorder, not receiving active psychiatric treatment, having a diagnosis of bipolar manic episodes, and having low platelet and HDL values constitute a risk of involvement in crime. Conclusions: The present study emphasizes the role of systemic inflammation in the pathophysiology of patients with BD with and without criminal offenses and the relationship between inflammation and criminal behavior.Öğe Inflammation markers in patients with psychotic disorder who have committed offenses and their relationship with criminal behavior(Routledge Journals, Taylor & Francis Ltd, 2025) Yildiz, Sevler; Emir, Burcu Sirlier; Kilicaslan, Asli Kazgan; Kurt, Osman; Ugur, Kerim; Sehlikoglu, Seyma; Atmaca, MuradThe role of inflammation in the etiology of psychotic disorders (PD) is well-established. This study aimed to identify inflammation parameters in patients diagnosed with PD, assess their potential as biomarkers, and examine their relationship with criminal behavior. This retrospective study comprised three groups: 530 patients diagnosed with PD who had committed crimes (offenders with PD), 530 patients with PD who had not committed crimes (non-offenders with PD), and 530 healthy controls, totaling 1,590 participants. Routine hematological tests were used to measure neutrophil, lymphocyte, monocyte, and platelet counts, high-density lipoprotein (HDL), systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), and neutrophil/HDL (NHR), lymphocyte/HDL, platelet/HDL (PHR), and monocyte/HDL (MHR) ratios. Offenders with PD exhibited significantly higher levels of SII, SIRI, PHR, NHR, LHR, neutrophils, and monocytes compared to non-offenders with PD and healthy controls (p < 0.001). The criminal group had lower HDL and lymphocyte levels than the remaining two groups (p < 0.001). Among those treated in forensic psychiatry units, patients with two or more treatments showed significantly higher SIRI values compared to those with only one treatment (p = 0.045). Non-offenders with PD had higher platelet values than the remaining two groups (p < 0.001). This study underscores the role of systemic inflammation in the pathophysiology of psychotic disorders through a comparison of patients who have and have not committed crimes, highlighting the relationship between inflammation and lipid metabolism. Further research is required to clarify these findings.Öğe Investigation of the relationship between forensic psychiatry patients' violent behaviors and levels of treatment adherence and hope(Ugur, Kerim, 2021) Polat, Hatice; Ugur, KerimINTRODUCTION: This study was conducted to examine the relationship between violent behaviors of forensic psychiatry patients and their adherence to treatment and level of hope. METHODS: This study used a descriptive and correlational research design. July 2020 October 2020 data of the study was collected and a total of 134 patients participated in the study. A personal information form, Morisky Adherence Scale, Taylor crime violence Rating Scale and Herth Hope Scale were used for data collection. RESULTS: It was determined that 40.3% of the patients participating in the study exhibited moderate violent behavior, 63.4% had low levels of adherence to treatment and hope levels were 40.14±21.80. It was determined that there was a negative significant relationship between the levels of hope and treatment adherence of violent behavior of patients (p<0.05). DISCUSSION AND CONCLUSION: It was determined that most forensic psychiatry patients had low adherence treatment and moderate violent behavior, and that there was a negative association between patients ' violent behavior and their level of hope and adherence to treatment.
