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Öğe Antidepresanların ilaç ilişkili hareket bozuklukları ve cinsel yan etkiler açısından karşılaştırılması(Çukurova Üniversitesi, 2021) Namlı, Zeynep; Tamam, Lut; Demirkol, Mehmet Emin; Karaytuğ, Mahmut Onur; Uğur, Kerim; Davut, Özge ErişAmaç: Çalışmamızda farklı antidepresan gruplarının cinsel yan etkiler, daha az bilinen uyku bruksizmi ve nörolojik yan etkiler açısından karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmanın örneklem grubunu 18-50 yaş aralığında, depresif bozukluklar ve/veya anksiyete bozuklukları tanısı ile ayaktan tedavi gören, 1 aydan uzun süredir antidepresan monoterapisi alan 406 hasta oluşturmaktadır. Tüm hastalara; sosyodemografik veri formu, Hamilton Depresyon Ölçeği (HAM-D), Hamilton Anksiyete Ölçeği (HAM-A), UKU Yan Etki Değerlendirme Ölçeği nörolojik yan etkiler bölümü, Arizona Cinsel Yaşantılar Ölçeği (ACYÖ) ve Morisky İlaç Uyum Ölçeği uygulanmıştır. Kullanılan antidepresanlar; seçici serotonin geri alım inhibitörleri (SSGİ), serotonin norepinefrin geri alım inhibitörleri (SNGİ ve vortioksetin olmak üzere üç gruba ayrılarak karşılaştırılmıştır. Bulgular: YAB tanılı hastalarda SNGİ kullananların UKU nörolojik yan etkiler ortalama puanı SSGİ kullananlardan anlamlı olarak yüksek belirlendi. Depresif bozukluk tanılı hastalarda; ilaç tedavisine yeterli uyum sırasıyla %91.3 oranında vortioksetin, % 73.8 oranında SSGİ ve %50 oranında SNGİ kullanan hastalarda belirlendi ve üç grup arasındaki fark istatistiksel olarak anlamlıydı. Sonuç: Antidepresan ilaç grupları bazı yan etkiler ve tedavi uyumu açısından birbirinden farklılık gösterebilmektedir. Antidepresan kaynaklı uyku bruksizmi ve hareket bozuklukları gibi daha az bilinen yan etkilerin daha iyi anlaşılması için prospektif çalışmalara ihtiyaç bulunmaktadır.Öğe A Case of Neuroleptic Malignant Syndrome After COVID-19 Vaccination and Possible Mechanisms of Vaccines in the Formation of This Syndrome(Taylor & Francis, 2022) Taşcı, İrem; Uğur, KerimNeuroleptic malignant syndrome COVID-19 Vaccine Fatal ComplicationÖğe The Correlation Between Serum Uric Acid Level and Certain Clinical Variables in Antisocial Personality Disorder Patients(2021-03-03) Yıldız, Sevler; Kazğan, Aslı; Kurt, Osman; Korkmaz, Sevda; Uğur, KerimObjectives: In this study, we aimed to compare serum uric acid levels in patients diagnosed with antisocial personality disorder with a healthy control group, and also to investigate the relationship between serum uric acid levels and impulsivity and aggressive attitudes. Methods: The study was conducted with 126 individuals (69 with antisocial personality disorder, 57 controls). The Sociodemographic Data Form, the Barratt Impulsivity Scale (BIS-11), and the Buss–DurkeeHostility Inventory (BDHI) were applied to all participants. Venous blood samples were collected from all participants to measure serum uric acid levels. Results: It was determined that both the BIS-11 and the BDHI sub-dimensions, and the total scores of the antisocial personality disorder patients were higher when compared to the healthy control group. The serum uric acid levels of the patient group were significantly higher when compared to those of the control group. Furthermore, there was a significant positive correlation between serum uric acid level and Barratt Impulsivity Scale–11 (r=0.635, P < .001) and Buss–Durkee Hostility Inventory (r=0.572, P < .001) scores. Conclusion: In our study, it was found that serum uric acid levels were higher in patients with antisocial personality disorder, which is characterized by impulsivity and aggressive behavior, when compared to the control group. The findings of the present study suggest that purinergic dysfunction may also play a role in the etiopathogenesis of the disease. Further studies are required to determine whether this was a cause or an outcome.Öğe Denetimli Serbestlik Polikliniğine Başvuran Madde Kullanım Bozukluğu Tanılı Bireylerde İntihar Davranışı(Galenos Yayınevi, 2021) Uğur, Kerim; Tamam, Lut; Demirkol, Mehmet Emin; Yıldız, Sevler; Kartal, Fatma; Kazğan, Aslı; Polat, HaticeAmaç: Bu çalışmada Denetimli Serbestlik (DS) Polikliniğine başvuran Madde Kullanım Bozukluğu (MKB) tanılıbireylerde psikolojik acı, çocukluk çağı ruhsal travmaları, aleksitimi, dürtüsellik ve psikolojik dayanıklılığın intihargirişimi ile ilişkisinin incelenmesi amaçlanmıştır.Yöntem: Çalışma DS Polikliniğine başvuran 120 kişi ve sağlıklı kontrol ile yapılmıştır. Tüm katılımcılara; SosyoDemografik Veri Formu, Çocukluk Çağı Ruhsal Travma Ölçeği (CTQ-28), Toronto Aleksitimi Ölçeği (TAÖ), PsikolojikAcı Ölçeği (PAÖ), Barratt Dürtüsellik ölçeği (BDÖ), Psikolojik Dayanıklılık ölçeği (PDÖ) uygulanmıştır.Bulgular: İntihar girişimi olan hastaların PAÖ, TAÖ, BDÖ, CTQ-28 ölçek puanlarının daha yüksek olduğu tespitedilmiştir. İntihar girişimi riskini tahmin etmek için kurulan modelde (forward stepwise) PAÖ, TAÖ-A, PDÖ-sosyalyeterlilik ve BDÖ-toplam değişkenlerinin modele anlamlı katkı yaptığı bulunmuştur. Anlamlı olan dört değişkeninintihar riskindeki değişimin % 65,6’sını açıkladığı tespit edilmiştir.Sonuç: MKB’lerde psikolojik acı, aleksitimi, dürtüsellik ve çocukluk çağı travmalarının yüksek, psikolojikdayanıklılığın daha düşük olmasının intihar riskini değerlendirmede öngörürücü etkenlerdir.Öğe Effects Of Electroconvulsive Therapy On Certain Attention Tests İn Patients With Schizophrenia(2021-12-01) Orman, Kübra; Kartalcı, Şükrü; Kartal, Fatma; Uğur, KerimIt is known that patients with schizophrenia have positive and negative symptoms, as well as deterioration in cognitive functions. The main objective of this study was to investigate the effects of electroconvulsive therapy (ECT) on certain attention tests in patients with schizophrenia. The study included 103 patients who were diagnosed with schizophrenia according to the DSM-5 diagnostic criteria (39 outpatients receiving antipsychotic treatment alone, 32 inpatients receiving ECT+antipsychotic treatment, and 32 inpatients receiving antipsychotic treatment alone) and 42 healthy volunteers. The Stroop and digit span tasks were used as attention tests. Disease severity was assessed using the Scales for the Assessment of Positive/Negative Symptoms. There was a significant deterioration in the Stroop 4 and Stroop time difference values in all the three patient groups. No significant deterioration was observed in the digit span test in any of the groups. The Stroop 4, Stroop time difference and Stroop spontaneous correction scores were found to be associated with both negative and positive symptoms in the ECT+antipsychotic treatment group. The Stroop spontaneous correction scores were associated with positive symptoms only in the group receiving antipsychotic treatment alone. The only significant improvement in the number of spontaneous corrections was observed in the ECT group after therapy compared to the baseline. However, no significant change was observed in the Stroop 4 and Stroop time difference results, which were impaired compared to the normal scores. In the group receiving only antipsychotic treatment, there were significant improvements in Stroop 4, Stroop time difference and number of spontaneous corrections after treatment. In this study, it was determined that ECT added to drug treatment had positive rather than negative effects on the patients’ performance in attention tests, although not as much as drug treatment. However, it should be considered that the group in which ECT was added to treatment consisted of more severe cases.Öğe Evaluation of arterial stiffness in patients with generalized anxiety disorder(2023) Yildiz, Sevler; Kılıçaslan, Aslı Kazğan; Uğur, Kerim; kurt, osman; KILIÇARSLAN, GÜLHANPurpose: Generalized anxiety disorder (GAD) is a psychiatric condition where both physical and mental symptoms are observed due to the activation of the sympathetic system. It is known that the disorder affects the cardiovascular system. The present study aimed to analyze arterial stiffness in GAD patients and compare the findings with healthy controls. Materials and Methods: 40 patients diagnosed with GAD and 40 healthy individuals were included in the study. Carotid and femoral artery intima-medial thickness (IMT) and arterial thickness parameters were measured with Doppler ultrasonography. Results: The femoral IMT of the patients was significantly low. Although the carotid IMT was higher in patients when compared to the controls, the difference was not statistically significant. A significant negative correlation was determined between fluoxetine equivalent dose and femoral IMT. There was a correlation between femoral IMT and fluoxetine equivalent dose. Conclusion: Arterial stiffness should be investigated for its potential to indicate cardiovascular risk in GAD. Further comprehensive studies should be conducted to clarify whether atherosclerosis symptoms were associated with the nature of the GAD or prescription medicine.Öğe Evaluation Of Depression, Self-esteem And Hopelessness In Patients Admitted To Psychiatry Outpatient Clinic In Geriatric Population During COVID-19 Outbreak(2021-09-26) Yıldız, Sevler; Kazgan, Aslı; Kurt, Osman; Uğur, KerimInfection control measures taken to ensure social isolation during the COVID-19 pandemic process seem to negatively affect the mental health of elderly individuals. In this study, it is aimed to examine the effects of pandemic on the mental health of the elderly. 150 patients over the age of 65 who were admitted to the psychiatry outpatient clinic for the first time during the pandemic period were included in the study. Socio demographic data form, Geriatric Depression Scale (GDS), Beck Hopelessness Scale (BHS), Rosenberg Self Esteem Scale (RSE) were applied to all cases after the psychiatric interview conducted by us. In the geriatric population, it was observed that there was a significant negative correlation between BHS and RSE (r = -0.241 p = 0.003), and a positive significant relationship between BHS and GDS (r = 0.478 p <0.001). There was no significant correlation between RSE and GHS (r = -0.042 p = 0.614). During the COVID-19 pandemic, it is understood that the hope level and self-esteem of the geriatric population are low, and their mood is depressive. Among the measures to be taken during infection control, we think that elderly people should be given psychosocial support, and thus a healthier environment can be offered to these individuals in terms of physical and mental aspectsÖğe Examination of alexithymia, psychological resilience and psychiatric symptoms in patients with persistent complex bereavement disorder(Malatya Turgut Özal Üniversitesi, 2022) Emir, Burcu Sırlıer; Yıldız, Sevler; Kılıçaslan, Aslı Kazğan; Uğur, Kerim; Kurt, OsmanBackground: The aim of this study is to examine alexithymia, psychological resilience, and sychiatric symptoms in patients with persistent complex bereavement disorder.Materials and Methods: A total of 62 participants were included in the study, 31 subjects diagnosed with PCBD and 31 healthy controls. Participants were administered the socio-demographic data form, Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Resilience Scale for Adults (RSA), Toronto Alexithymia Scale (TAS-20).Results: BAI (p<0.001), BDI (p<0.001), and TAS-20 (p<0.001) scale scores were found to be significantly higher in the patient group than in the control group. All sub-dimensions of the RSA scale total score were found to be significantly lower between both groups (p <0.001). The anxiety, depression, and lexithymia levels of the patients diagnosed with persistent complex bereavement disorder were significantly higher than the control group; psychological resilience levels were found to be significantly lower.Conclusions: We believe that identifying this situation will shape the psychosocial support to be given to individuals in the pathological mourning processÖğe Geriatrik Popülasyonda İntihar Davranışı Ve Deliryumun Psikiyatrik Acil Olarak Tanınması Ve Yönetimi(2022) Uğur, KerimGeriatrik popülasyonda intihar davranışı ve deliryumun psikiyatrik acil olarak tanınması ve yönetimiÖğe Markers of inflammation in patients with generalized anxiety disorder(2024) Yildiz, Sevler; Kılıçaslan, Aslı Kazğan; Emir, Burcu Sırlıer; TABARA, Muhammed Fatih; kurt, osman; SEHLİKOĞLU, ŞEYMA; Uğur, KerimPurpose: The aim of this study was to analyze the systemic immune response index, systemic immune inflammation index, neutrophil/HDL, lymphocyte/HDL, platelet/HDL, and monocyte/HDL ratio, used as inflammatory markers in patients with generalized anxiety disorder (GAD). Materials and Methods: A total of 864 participants, including 432 healthy controls and 432 patients diagnosed with GAD, were included in this study. High-density lipoprotein (HDL-c) levels, neutrophil, monocyte, lymphocyte, and platelet counts; systemic inflammatory response index (SIRI), systemic immune-inflammatory index (SII), neutrophil/high-density lipoprotein ratio (NHR), lymphocyte/high-density lipoprotein ratio (LHR), monocyte/high-density lipoprotein ratio (MHR), and platelet/high-density lipoprotein ratio (PHR) were calculated. Results: The median age of the case group was 35.50 (interquartile range: 28.00-44.00), while the median age of the control group was 35.00 (interquartile range: 28.00-44.00). In the GAD group, neutrophils, monocytes, SII, SIRI, NHR, LHR, MHR, and PHR were significantly higher, while platelets and HDL were significantly lower. Conclusions: This study highlights that elevated systemic inflammation markers, such as SII and SIRI, along with altered HDL ratios, may be associated with GAD. The findings support the hypothesis that inflammation plays a role in the etiopathogenesis of GAD, potentially contributing to both diagnosis and management.Öğe Methods of Coping With Psychological Pain and Stress in Antisocial Personality Disorder(2023) Emir, Burcu Sırlıer; Yildiz, Sevler; Kılıçaslan, Aslı Kazğan; SEHLİKOĞLU, ŞEYMA; kurt, osman; Uğur, KerimAim: Antisocial Personality Disorder (ASPD) is a personality dis - order in which the person has difficulty controlling his behaviors and impulses, harming both himself and his environment. In our study, we aimed to examine the psychological pain experienced by people with ASPD and the methods of coping with the stress they use to combat it. Material and Method: Forty patients and 40 healthy control groups were included in the study. Sociodemographic Data Form, Beck Depression Scale (BDI), Beck Suicide Scale (BSS), Psychache Scale (PS), and Styles of Coping with Stress (SCSS) were administered to the participants. Results: The BDI (p=0.037), BSS (p=0.009), PS (p=0.008) and SCSS-helpless approach (p=0.01) scores of the patients in the pa - tient group were significantly higher than the scores of the control group. On the other hand, the scores of SCSS-self-confident ap - proach (p=0.001) and SCSS-searching for social support (p<0.001) were found to be significantly lower than the scores of the control group. In the patient group, there was a positive correlation between BDI and BSS, PS and SCSS-optimistic approach. On the other hand, there was a significant negative correlation between BDI and SCSS-self-confident approach and SCSS-seeking social support Conclusion: In our study, depression, suicide, and psychological pain were found to be significantly higher in people with ASPD compared to the control group, and it was determined that they used ineffective coping strategies. We think that early interventions for the treatment of psychological pain, such as suicidal ideation, determination of depression, and providing support for using ef - fective coping strategies, may be effective in preventing self-de - structive behaviors or suicides in ASPD, and therefore may change the course of the disease.Öğe Molecular Mechanism of the Protective Effect of Tianeptine Against Ketamine-Induced Cardiac Injury in Rats(2021-10-26) Yıldız, Sevler; Uğur, Kerim; Taş, Hakan; Özçiçek, Fatih; Kuyrukluyıldız, Ufuk; Mendil, Ali; Çankaya, Murat; Mamedov, Renad; Süleyman, HalisKetamine is a short-acting anesthetic drug that is derived from phencyclidine. Ketamine is used to treat depression and chronic pain disorders, as well as for anesthesia, analgesia, and sedation. Ketamine’s sympathomimetic characteristic causes cardiotoxicity. The pathophysiology of ketamine’s harmful impact has been linked to reactive oxygen species (ROS) and proinflammatory cytokines such as interleukin 1 beta (IL-1), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-?). Tianeptine is an antidepressant that works similarly to tricyclic antidepressants. According to studies, tianeptine reduces the production of proinflammatory cytokines such as ROS, IL-1, IL-6, and TNF-?. Tianeptine has a sympatholytic action as well. All of this evidence suggests that tianeptine might help to reduce ketamine cardiotoxicity. The goal of our research is to use biochemical and histological techniques to see how tianeptine affects ketamine-induced cardiotoxicity in rats.Öğe Premenstrual disforik bozukluk tanılı hastaların kişilik özellikleri, anksiyete duyarlılığı, anksiyete ve depresyon seviyeleri(ÇUKUROVA ÜNİVERSİTESİ, 2021-09-17) Yıldız, Sevler; Kazğan, Aslı; Kurt, Osman; Uğur, Kerim; Atmaca, MuradAmaç: Bu çalışmada Premenstrual disforik bozukluk (PMDB), tanılı hastaların kişilik özelliklerini, anksiyete duyarlılığını, anksiyete ve depresyon düzeylerini değerlendirmeyi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya, PMDB tanısı olan ve psikiyatrik tedavi öyküsü olmayan 40 hasta ve yine hasta grubuyla benzer sosyodemografik özelliklere sahip sistemik ve psikiyatrik hastalık öyküsü olmayan 40 sağlıklı kadın dahil edildi. Tüm katılımcılara Anksiyete-Duyarlılıkİndeksi-3 (ADİ-3), Beck Anksiyete Ölçeği (BAÖ), Beck Depresyon Ölçeği (BDÖ) ve Gözden Geçirilmiş Eysenck Kişilik Anketi-Kısaltılmış Formu (EKA-GGK) uygulandı. Bulgular: Hasta grubunun EKA-GGK nörotisizm, psikotizm, yalan alt ölçekleri ve toplam puanı kontrol grubunun puanından yüksek saptandı. Hasta grubunun ADİ-3 fiziksel, bilişsel, sosyal alt boyutları ve toplam puanı kontrol grubunun puanından yüksek olarak saptandı. PMDB tanılı hastaların BDÖ ile BAÖ ölçek puanı kontrol grubunun puanından yüksek bulundu. Sonuç: Anksiyete duyarlılığı yüksek olan, psikotizm ve nevrotik kişilik özelliklerine sahip kadınlarda bu durum PMDB gelişimini ya da hastalığın seyrini etkileyebilir.Öğe Relationship between obsessional dissociation and family adjustment and anxiety sensitivity in individuals with obsessive-compulsive disorder(2023) polat, hatice; KARTAL, fatma; Uğur, KerimPurpose: The aim of this study was to determine the relationship between obsessional dissociation, family accommodation, and anxiety sensitivity in individuals with obsessive-compulsive disorder (OCD). Materials and Methods: The participants of this descriptive and relationship-seeking study were 62 individuals with OCD and 43 healthy controls. We collected data using a sociodemographic data form, the Yale-Brown Obsessive Compulsive Scale (YBOCS), the Family Accommodation Scale-Patient Version (FAS-PV), the Anxiety Sensitivity Index-3 (ASI-3), and the Van Obsessional Dissociation Questionnaire (VOD-Q). Results: Both the ASI-3 and VOD-Q subscale and global scores of the patients participating in the study were higher than those of the healthy controls, and there was a statistically significant difference between the two groups. Sixty-two percent of the total score of VOD-Q was explained by the ASI-3 total and subscale scores, 16% by the YBOCS total and subscale scores, and 11% by the FAS-PV total and subscale scores (F:38.622; F:6.797; and F:2.941, respectively). Conclusion: In our study, individuals diagnosed with OCD had higher levels of obsessional dissociation than healthy individuals and anxiety sensitivity, obsessive-compulsive symptoms, and family accommodation are effective in the development of obsessional dissociation in individuals diagnosed with OCD.Öğe The Relationship Between the Oxytocin Level and Rejection Sensitivity, Childhood Traumas, and Attachment Styles in Borderline Personality Disorder(Korean Neuropsychiatric Association, 2022) Kartal, Fatma; Uğur, Kerim; Mete, Burak; Demirkol, Mehmet Emin; Tamam, LutObjective In this study, it is aimed to investigate the relationship between the oxytocin level and the rejection sensitivity, childhood mental traumas, and attachment styles in patients diagnosed with borderline personality disorder (BPD).Öğe The relationship of suicidal ideation with psychological pain and anger rumination in patients with major depressive disorder(Elsevier, 2021) Uğur, Kerim; Polat, HaticeObjectıve The study was conducted to determine the association between ruminating anger and mental pain with suicidal ideation in patients diagnosed with major depression disorder. Methods The study with 156 patients diagnosed with major depressive disorder was carried out in a cross-sectional study design. Personal Information Form, Reflection on Anger Scale, Psychological Pain Scale and Beck Depression Scale were used. Results It was concluded that there was a statistically equal directional and linear relationship between the Meebunney and Beck depression scores of all patients diagnosed with a major depressive disorder and the total reflective anger score and its sub-dimensions. Suicidal attempts and psychological pain and depression levels were found to be effective in the increase in suicidal ideation in the patients with major depressive disorder. Conclusions Studies with larger samples are recommended to determine the factors that may pose a risk of suicidal ideation in patients diagnosed with majör depressive disorder.Öğe Resilience, depression and burnout levels in caregivers of patients followed in the forensic psychiatry service(2023) Yildiz, Sevler; Kılıçaslan, Aslı Kazğan; Emir, Burcu Sırlıer; kurt, osman; Uğur, KerimObjective: It is known that psychiatric diseases also affect the quality of life of patients' relatives. The aim of this study is to examine the level of resilience, depression and burnout of the caregivers of forensic psychiatry patients in order to recognize the mental problems that may be experienced by relatives of forensic psychiatry patients who have com- mitted crimes in addition to psychiatric illness. Method: 90 high-security forensic psychiatry patient relatives were included in the study. Sociodemographic data form, Beck Depression Inventory (BDI), Adult Resilience Scale (RSA) and Maslach Burnout Inventory (MBI) were admi- nistered to all participants. Results: BDI score of caregivers was 10.8±7.7, RSA-total 99.8±12.5, emotional burnout score from MBI subscales 22.5±3.4, depersonalization score 9.4±2.2, personal success score was determined as 16.8±5.4. There was a signifi- cant difference between the duration of caregiving in terms of BDI score (p<0.01). The BDI score of the caregivers of the patients with criminal liability was found to be significantly higher than the score of the caregivers of the patients without criminal liability (p< 0.01). Discussion: It was observed that the level of psychological resilience was good in people who took care of psychiatric patients who were subjected to forensic psychiatric examination, but they had mild depression and moderate burnout. It is seen that the relatives of the patients are affected psychologically and the necessary psychosocial support can be positive for the caregivers.Öğe SCuopmeprvairsiisoonn woift hsu cbosntatrnocles iuns etersrm usn doefr a jtutdeinc-ial ttiioonn rdeegfiucliatt ihoynp edrifafcictiuvlittiye sd(2024) Akan, Mustafa; Uğur, Kerim; AYAZ, NusretObjective: Substance abuse and addiction are reported to be approximately 2 times more common in individuals diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) compared to the general population. Adults with ADHD have been stated to have difficulties in emotion regulation as well as core symptoms of the disease. In this study, it was aimed to evaluate individuals who applied to a university hospital psychiatry clinic probation clinic in terms of attention deficit hyperactivity disorder and emotion regulation difficulties. The hypothesis of the study is that individuals who apply to the outpatient clinic will have higher ADHD symptoms and emotion regulation difficulties than healthy controls. Method: The research was conducted between 18.06.22-30.10.22. 135 male patients diagnosed with substance use disorder and 141 healthy volunteers without any psychiatric disease were included in the study. Adult ADHD selfreport scale (ASRS), Difficulty in Emotion Regulation Scale Short Form (DERS-16), and sociodemographic data form were administered to the participants. Results: The probation group's ASRS total score, attention deficit and hyperactivity/impulsivity subscale scores were found to be statistically significantly higher than the control group (p=0.004, p=0.005, p=0.007, respectively). Also DERS-16 impulse and nonacceptance subscale scores of the probation group were statistically significantly higher than the control group (p=0.001, p=0.015, respectively). Discussion: ADHD and accompanying emotion regulation difficulties may increase the risk of substance use in adults. Considering these clinical features in individuals applying to the probation outpatient clinic may make therapeutic interventions more effective.Öğe Servikal ve lomber disk hernili hastalarda ruhsal bulguların değerlendirilmesi(Çukurova Üniversitesi, 2021) Kartal, Fatma; Karlıdağ, Rıfat; Uğur, KerimAmaç: Literatürde kronik bel ve boyun ağrıları ile ruhsal durumun değerlendirildiği çok sayıda çalışma bulunmaktadır ancak spesifik olarak yapısal patolojinin tespit edildiği bel veya boyun ağrısı ile ruhsal bulgular arasındaki ilişkiyi inceleyen çalışma sayısı çok azdır. Çalışmamızda servikal ve lomber disk hernili hastaların ruhsal bulgularını değerlendirmeyi amaçladık. Gereç ve Yöntem: Araştırmaya, 42 sağlıklı kontrol ve en az 6 aydır süren bel ya da boyun ağrısı şikayeti ile Nöroşirürji ve Fizik Tedavi ve Rehabilitasyon polikliniklerine başvuran 28'i servikal, 36'sı lomber disk hernisi tanısı almış hastalar dahil edilmiştir. Psikiyatri uzmanı tarafından hasta ve kontrol grubuna DSM-5 tanı kriterleri temel alınarak yarı yapılandırılmış psikiyatrik görüşme yapılmıştır. Tüm katılımcılara, Sosyo-demografik Bilgi Formu, Beck Anksiyete Ölçeği, Beck Depresyon Ölçeği, Durumluk ve Sürekli Kaygı Envanteri, Yaygın Anksiyete Bozukluğu-7 Testi, Yaşam Kalitesi Ölçeği-Kısa Form-36, Bedensel Duyumları Abartma Ölçeği dolduruldu. Hasta gruplarına, Visüel Analog Skala, servikal disk hernili hastalara Boyun Ağrı ve Özürlülük indeksi, lomber disk hernili hastalara Oswestry disabilite indeksi dolduruldu. Bulgular: Hem servikal hem de lomber disk hernili grupta, anksiyete düzeyi yüksekken, depresyon ve bedensel duyumları abartma düşük saptanmıştır. Emosyonel rol güçlüğü dışında, yaşam kalitesi alt parametreleri hasta gruplarında anlamlı olarak düşük saptanmıştır. Ağrı ve özürlülük arasında orta derecede korelasyon tespit edilmiştir. Ağrı veya özürlülük ile anksiyete veya depresyon düzeyleri arasında da orta derecede korelasyon saptanmıştır. Sonuçlar: Çalışmamızda her iki hasta grubunda anksiyete düzeyininin yüksek olması, belki de disk herniasyonundaki dejenerasyonun progresyonunda patolojik hale gelen anksiyetenin etkili olabileceğini düşündürmektedir. Lomber ve servikal disk hernili hastaların tedavisinde ağrı dışında, yaşam kalitesi ve özürlülüğü etkileyebilecek psikolojik faktörler de saptanmalı ve multidisipliner tedavi yaklaşımları uygulanmalıdır.Öğe Şizofreni Tanılı Hastalarda Serum HMGB1 ve Beklin 1 Düzeyleri(2024) Yildiz, Sevler; Kılıçaslan, Aslı Kazğan; Emir, Burcu Sırlıer; Uğur, Kerim; KILIC, FARUKAmaç: Şizofreni etiyopatogenezinde inflamasyonun rol oynadığı bilinmektedir. Bu çalışmada şizofreni tanılı hastalarda yüksek mobilite grup kutusu 1 protein (HMGB1) ve Beklin 1 seviyeleri ile klinik değişkenler arasındaki ilişki incelenmiştir. Metod: Çalışmaya 43 şizofreni hastası ve 43 sağlıklı kontrol grubu dahil edildi. Tüm katılımcılara sosyodemografik veri formu, Pozitif Negatif Semptom Skalası (PANSS), Klinik Global İzlem Ölçeği (CGI) uygulandı. Ölçekler doldurulduktan sonra hem hasta hem de kontrol grubundan serum HMGB1 ve Beklin 1 seviyelerini ölçmek için venöz kan örneği alındı. Santrifüj sonunda elde edilen serum örnekleri Enzyme-Linked ImmunoSorbent Assay (ELISA) yöntemi ile ölçüldü. Bulgular: Şizofreni hastalarında serum HMGB1 seviyesi kontrol grubuna göre anlamlı düzeyde yüksek saptandı. Serum Beklin 1 seviyeleri ise hasta grubunda kontrol grubuna göre anlamlı düzeyde düşük olarak bulundu. Ayrıca HMGB1 ve Beklin-1 düzeyleri arasında negatif ilişki tespit edildi. Sonuç: Sonuç olarak, mevcut araştırma şizofreni olan hastalarda HMGB1’in arttığını, Beklin 1’in azaldığını ve bu bulguların şizofreni patogenezinde otofajinin rolüne katkıda bulunabileceğini göstermektedir.
