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Öğe A Little-Known Subject: Lead and Cardiac Toxicity(Elsevier Science Inc, 2013) Demircelik, Muhammed Bora; Yilmaz, Omer Caglar; Yilmaz, Hinc; Tutkun, Engin; Gurel, Ozgul Malcok; Atar, Inci Asli; Cetin, Zehra Guven[Abstract Not Available]Öğe Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury(Walter De Gruyter Gmbh, 2015) Bal, Ceylan; Gungor, Oya Torun; Celik, Huseyin Tugrul; Abusoglu, Sedat; Uguz, Nihal; Tutkun, Engin; Yilmaz, Omer HincObjective: Our aim was to determine whether cystatin C level has a superiority to creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute mercury exposure in children. Eight different glomerular filtration rate calculation formulas which have been used creatinine and/or cystatin C were also compared. Methods: Serum urea, creatinine and cystatin C values of 39 mercury exposed children were measured. Glomerular filtration rates were calculated by eight different formulas. Patient group was divided into three subgroups according to mercury levels. Results: Cystatin C and mercury levels of the patients were found significantly different from control group (p<0.001). There was not a significant difference in creatinine and urea values between two groups (p=0.913, p=0.236). There was not a significant difference between patient and control groups in GFR calculations which have been used serum creatinine and height or which have been used urea additional to them (p=0.069, p=0.559, p=0.424, p=0.945, respectively), but there was a significant difference between patient and control groups in GFR calculations which have been used cystatin C only or creatinine, urea and height in addition to this (p<0.001, p<0.001, p=0.042, p<0.001, respectively). In sugroup analysis, cystatin C results and the results of three GFR calculations of four GFR calculations which were used cystatin C were found different in control group according to subgroups but there was not a difference between subgroups. Conclusion: Cystatin C level is a better indicator than creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute exposure of mercury. Formulas using cystatin C gave better results than formulas using creatinine and height in estimation of glomerular filtration rate.Öğe The association between PTX3 and serum manganese levels of welders in comparison with controls: An application of anti-inflammatory biomarker(2021-07-11) Öztan, Özgür; Türksoy, Vugar Ali; Deniz, Serdar; İritaş, Servet Birgin; Tutkun, EnginAim: The purpose of this study was to compare serum PTX3 levels of manganese-exposed welders with non-exposed controls to evaluate the nature of the manganese-induced inflammatory response. Material and Method: Overall, we collected 103 research samples (Mn-Exposed Welders Group:51 and Non-Exposed Controls: 52). PTX-3 levels were analyzed in the serum samples by the ELISA method, while Mn levels in whole blood specimens were quantified by the inductively coupled plasma (ICP-MS) method. Results: The mean values of manganese and Pentraxin-3 of the control group were found to be significantly lower than those of the exposure group (Mn levels: 5.04±2.32 µg/L vs. 11.54±3.09 µg/L; PTX-3: 36.96±24.20 ng/mL vs. 48.29±27.13 ng/mL; p<0.05). Conclusion: This hypothetical and observational investigation highlighted the relationship between Mn levels and PTX-3 for the first timeÖğe Effect of different selenium levels on thyroid hormone synthesis(Refik Saydam National Public Health Agency (RSNPHA) turkhijyen@rshm.gov.tr, 2015) Bal, Ceylan Demir; Büyükşekerci, Murat; Ercan, Müjgan; Hocaoğlu, Asim; Çelik, Hüseyin Tuğrul; Abuşoğlu, Sedat; Tutkun, EnginObjective: As an essential element, selenium is very important for thyroid functions. Iodothyronine deiodinase-I is a selenium containing enzyme that is responsible for production of triiodothyronine (T3) from thyroxin (T4) in peripheral tissues. The aim of this study is to investigate the effect of different levels of selenium on thyroid hormone synthesis. Methods: 303 participants who had admitted to several clinics of Ankara Occupational Diseases Hospital and whose serum thyroid hormone and selenium levels were determined between years 2012 and 2014 were separated into 3 groups according to serum selenium levels. Group 1: 50-75?g/L, group 2: 75,1-100?g/L, group 3: 100,1-125?g/L. The thyroid stimulating hormone (TSH), free T3 (FT3) and free T4 (FT4) levels of groups were compared with each other. Results: There was statistically non-significant difference among 3 groups concerning the serum TSH and FT3 levels (p=0,91; p=0,18). Group 3 serum FT4 levels were lower than other groups. FT4 levels of group 3 were significantly different from group 1 (p= 0,005). T3/T4 ratio was significantly higher in group 3 than other groups (p=0,004). There was a negative correlation between selenium and FT4 levels (r=-0,184; p=0,001), whereas a positive correlation existed between selenium and T3/T4 ratio (r=0,178, p=0,002). Conclusion: Selenium has an important role in thyroid functions and FT4 levels increase in selenium deficiency. High FT4 levels should be considered in low selenium levels. © 2015 Elsevier B.V., All rights reserved.Öğe Investigation of the potential use of VCAM-1, TNF-?, IL-10 and IL-6 as biomarkers of nickel exposure(2021) öztan, özgür; TURKSOY, Vugar Ali; Deniz, Serdar; Tutkun, EnginObjectives: Industrial and agricultural activities such as mining, smelting, and the discharging of industrial and domestic wastewater have increased the severity of heavy metal pollution in environments. Nickel poisoning continues to be an important occupational health problem in many branches of industry, especially coating. Occupational exposure to nickel can occur through skin contact or inhalation of nickel-containing aerosols, dust, or fumes. As a result of the toxic effect of nickel, it can cause various health problems, including respiratory and dermatological effects. Material and Method: The study included 56 male workers exposed to nickel in a coating factory (Ni-exposed group) and 44 non-exposed male workers (control group). Vascular Cell Adhesion protein (VCAM)-1, Tumor Necrosis Factor (TNF)-?, Interleukin (IL)-10, and IL-6 levels of serum were analyzed using enzyme-linked immunosorbent assays (ELISA). Ni levels were determined using inductively coupled plasma mass spectrometry (ICP-MS) in urine samples. Results: Significant intergroup differences were observed in the levels of all inflammatory parameters such as VCAM-1, TNF-?, IL-10 and IL-6 (p<0.01 for all). Conclusions: The correlations between increased inflammatory biomarkers levels and exposed/control groups suggest a close relationship between inflammation and toxicity. This relationship provides a clinical model for the early diagnosis of nickel toxicity.Öğe Mean platelet volume level in chromium exposed workers(Elsevier Ireland Ltd, 2014) Hocaoglu, Asim; Bal, Ceylan; Celik, Huseyin Tugrul; Abusoglu, Sedat; Yilmaz, Hinc; Tutkun, Engin[Abstract Not Available]Öğe Silicosis And Methylated Arginines/L-Arginines: Case-Control Adapted A Cross-Sectional Design(Yozgat Bozok University Scientific Research Foundation, 2021-09-19) Öztan, Özgür; Türksoy, Vugar Ali; Deniz, Serdar; Coşkun Beyan, Ayşe; İritaş, Servet Birgin; Ercan Karadağ, Müjgan; Tutkun, EnginAim: Silicosis has long been recognized as an important occupational lung disease that is included in the group of pneumoconiosis. As already well-known silicosis is a progressive pneumoconiosis characterized by fibrosis in the lungs. Also, chronic exposure to silica may cause chronic obstructive pulmonary disease, emphysema, lung cancer, and pulmonary fibrosis. Asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA), and L-NMMA (NG-mono-methylated-Larginine) are the products of protein arginine methyltransferase (PRMT) enzymes. The aim of this study is to investigate the relationship between silicosis and arginine metabolites in silica exposed and non-exposed workers. Material and Method: 180 male subjects (90 non-exposed workers (age matched-control) and 90 workers diagnosed with silicosis occupational physician based on radiological and clinical findings and exposure history-(silica-exposed) were included in this study. The serum levels arginine, ADMA, SDMA, and L-NMMA were determined using enzyme-linked immunosorbent assay. Results: ADMA, SDMA, L-NMMA values were significantly higher in the silica-exposed group compared to the control group. The positive correlations were observed between methylated arginine parameters such as ADMA and SDMA, ADMA and L-NMMA levels (r=0.43, r=0.60; p<0.01). The negative correlations were found between SDMA and arginine/ADMA, L-NMMA, and arginine/ADMA, arginine and SDMA/ADMA, arginine/ADMA and SDMA/ADMA levels, respectively (r=-0.22; r=-0.22, r=-0.34, r=- 0.29; p<0.01). The strongest positive correlation was found between arginine and arginine/ ADMA ratio, and the strongest negative relationship between ADMA and arginine/ADMA ratio, respectively (r=0.87; r= -0.48; p<0.01). Conclusion: The results could provide additional insight into understanding the disease and the potential for developing biomarkers.Öğe Silicosis and methylated arginines/L-arginines: case-control adapted a cross-sectional design(2021) öztan, özgür; TURKSOY, Vugar Ali; Deniz, Serdar; Beyan, Ayse Coskun; iritaş, servet birgin; Ercan, Müjgan; Tutkun, EnginAim: Silicosis has long been recognized as an important occupational lung disease that is included in the group of pneumoconiosis. As already well-known silicosis is a progressive pneumoconiosis characterized by fibrosis in the lungs. Also, chronic exposure to silica may cause chronic obstructive pulmonary disease, emphysema, lung cancer, and pulmonary fibrosis. Asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA), and L-NMMA (NG-mono-methylated-L-arginine) are the products of protein arginine methyltransferase (PRMT) enzymes. The aim of this study is to investigate the relationship between silicosis and arginine metabolites in silica exposed and non-exposed workers. Material and Method: 180 male subjects (90 non-exposed workers (age matched-control) and 90 workers diagnosed with silicosis occupational physician based on radiological and clinical findings and exposure history-(silica-exposed) were included in this study. The serum levels arginine, ADMA, SDMA, and L-NMMA were determined using enzyme-linked immunosorbent assay. Results: ADMA, SDMA, L-NMMA values were significantly higher in the silica-exposed group compared to the control group. The positive correlations were observed between methylated arginine parameters such as ADMA and SDMA, ADMA and L-NMMA levels (r=0.43, r=0.60; p<0.01). The negative correlations were found between SDMA and arginine/ADMA, L-NMMA, and arginine/ADMA, arginine and SDMA/ADMA, arginine/ADMA and SDMA/ADMA levels, respectively (r=-0.22; r=-0.22, r=-0.34, r=- 0.29; p<0.01). The strongest positive correlation was found between arginine and arginine/ ADMA ratio, and the strongest negative relationship between ADMA and arginine/ADMA ratio, respectively (r=0.87; r=-0.48; p<0.01). Conclusion: The results could provide additional insight into understanding the disease and the potential for developing biomarkers.Öğe The association between PTX3 and serum manganese levels of welders in comparison with controls: An application of anti-inflammatory biomarker(2021) öztan, özgür; TURKSOY, Vugar Ali; Deniz, Serdar; TUTKUN, Lütfiye; iritaş, servet birgin; Tutkun, EnginAim: The purpose of this study was to compare serum PTX3 levels of manganese-exposed welders with non-exposed controls to evaluate the nature of the manganese-induced inflammatory response. Material and Method: Overall, we collected 103 research samples (Mn-Exposed Welders Group:51 and Non-Exposed Controls: 52). PTX-3 levels were analyzed in the serum samples by the ELISA method, while Mn levels in whole blood specimens were quantified by the inductively coupled plasma (ICP-MS) method. Results: The mean values of manganese and Pentraxin-3 of the control group were found to be significantly lower than those of the exposure group (Mn levels: 5.04±2.32 ?g/L vs. 11.54±3.09 ?g/L; PTX-3: 36.96±24.20 ng/mL vs. 48.29±27.13 ng/mL; p<0.05). Conclusion: This hypothetical and observational investigation highlighted the relationship between Mn levels and PTX-3 for the first time.Öğe Toxic metal and essential trace element levels of blood donors(Derman Medical Publishing secretary@jcam.com.tr, 2016) Akinci, Ismail; Tutkun, Engin; Aliyev, Ali Ali; Yilmaz, Hin? Ömer; Yüksel, Bayram; Kayaaltı, Zeliha; Söylemezoğlu, TülinAim: Blood donors are screened for various pathogens including hepatitis and cytomegalovirus. Screening for toxic metal levels is not routine process. The aims of our study were to determine the whole blood levels of toxic metals, cadmium and lead, and levels of the trace elements iron, zinc, and copper, of non-exposed Turkish subjects and also to identify individuals living under the risk of chronic metal toxicity. Material and Method: Whole blood lead and cadmium levels were analyzed by Graphite Furnace Atomic Absorption Spectrometry. Metal levels were determined in the whole blood and serum samples of 211 male blood donors (aged 19 to 55; 33.71±8.69 years). Statistical analysis was performed by SPSSv16. Results: Average levels of cadmium, lead, zinc, copper and iron were found to be 1.27±0.88 µg L-1, 25.1±12.44 µg L-1, 0.97±0.16 mg L-1, 1.10±0.21 mg L-1, and 476.53±42.41 mg L-1, respectively. Donor age had a statistically significant positive correlation only with copper levels (p<0.01). There were not any significant correlations between BMI and any of the measured metal levels (p>0.05). A statistically significant association was found between smoking and cadmium levels (p<0.01). Discussion: Results may provide information for toxicologists and clinical chemists to determine whether people have trace element deficiencies or have been exposed to higher levels of toxic metals. © 2017 Elsevier B.V., All rights reserved.
