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    Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF
    (Springer/Plenum Publishers, 2015) Pekel, Aslihan; Gonenc, Aymelek; Turhan, Nilgun Ozturk; Kafali, Hasan
    The Fas-Fas Ligand interaction is one of the essential events for the induction of apoptosis whereas the exact role of their soluble forms in the reproductive system is still not fully understood. Also oxidative stress in the pathogenesis of infertility causing diseases in women and has been suggested as one of the important factors that negatively affect IVF outcome. In this study, our aim was to evaluate serum and follicular fluid levels of soluble Fas soluble Fas Ligand, malondialdehyde, superoxide dismutase and total antioxidant capacity in patients undergoing IVF and compared with controls. This study included 109 patients. Patients were classified as unexplained infertility (N = 31), PCOS (N = 19), tubal factor (N = 9) and endometriosis (N = 10) and compared with male factor infertility (N = 40) that was the control group. sFas and sFasL levels were measured by immunoassay method. MDA, SOD and TAC levels were measured by colorimetric method. Patients with unexplained infertility, PCOS and tubal factor had significantly lower sFas levels compared with their controls (respectively, p < 0.01, p < 0.05, p < 0.05). However, SOD activity in unexplained infertility, PCOS and endometriosisgroupswere significantly higher than control group (p < 0.01).Decreased follicular fluid TAC levels were found in all patient groups compared with controls (respectively, p < 0.01, p < 0.05, p < 0.01, p < 0.01).Patients with tubal factor had significantly higher serum sFasL (p < 0.05), but lower follicular fluid sFasL levels (p < 0.05) compared with unexplained infertility. Tubal factor and endometriosis groups had lowerfollicular fluid TAC levels compared to unexplained infertility and PCOSgroups (p < 0.01). In this study, serum and follicular fluid sFas levels were decreased and antioxidant activity was impaired in infertility, possibly implying increased apoptosis. Especially in unexplained infertility group changes in this parametres more remarkable.
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    Effects of the etonogestrel contraceptive implant (Implanon®) on bone metabolism during lactation: a prospective study
    (Bmj Publishing Group, 2017) Duvan, Candan Iltemir; Onaran, Yuksel; Keskin, Esra Aktepe; Yuce, Ebru; Yanik, Burcu; Kafali, Hasan; Turhan, Nilgun Ozturk
    Aim To evaluate the effects of the etonogestrel contraceptive implant (Implanon (R)) on bone metabolism in lactating women using markers for bone formation and resorption. Study design This single-centre, prospective cohort study was conducted in Turgut Ozal University Medical Faculty Obstetrics and Gynecology Department with healthy lactating women aged between 24 and 38 years to compare the effect on bone metabolism of 6 months' use of either the implant or a non-hormonal contraceptive method. The study group (n=25) used an implant and the control group (n=25) used a non-hormonal contraceptive intrauterine device inserted 40 days' postpartum. Bone metabolism differences at the time of insertion and after 6 months were assessed quantitatively by biochemical analysis of serum and urine samples. Results At baseline, serum levels of bone metabolism parameters were similar for the two groups. In the implant group, serum alkaline phosphatase (ALP) levels decreased (p=0.004) and total protein levels increased (p=0.045) at 6 months. In the control group, serum levels of bone metabolism parameters did not change at 6 months compared to baseline. However, serum levels of phosphorus (p=0.013) and ALP (p=0.003) decreased at 6 months compared to baseline. Conclusion Six months' postpartum use of Implanon was found to have no deleterious impact on bone turnover in healthy lactating women.
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    Is the level of maternal serum prohepcidin associated with preeclampsia?
    (Taylor & Francis Inc, 2015) Duvan, Candan Iltemir; Simavli, Serap; Keskin, Esra Aktepe; Onaran, Yuksel; Turhan, Nilgun Ozturk; Koca, Cemile
    Objective: The objective of the study was to compare pro-hepcidin, hemoglobin (Hb) concentration, hematocrit (Hct), C-reactive protein (CRP), IL-6 and iron status parameters in preeclamptic (PE) and healthy pregnant women, and to examine the relationship between serum pro-hepcidin levels and iron parameters of preeclampsia (PE). Methods: In a prospective controlled study, we collected serum from women with normal pregnancy (n = 37) and from women with PE (n = 30) at the Department of Obstetrics and Gynecology at Turgut Ozal University between February 2010 and January 2013. Pro-hepcidin, hemoglobin (Hb) concentration, hematocrit (Hct), CRP, IL-6 and iron status parameters were measured in all patients and compared between groups. Results: Levels of serum prohepcidin in PE and control groups were similar and amount 69.4 +/- 19.7 and 71.9 +/- 22.1 ng/ml, respectively. The difference was not statistically significant (p: 0.694). On the other hand, the study group had a statistically lower iron binding capacity (IBC), total iron binding capacity, transferin, total protein, albumin levels (p<0.05). No significant differences were found among prohepcidin, Hb concentration, Hct, iron, ferritin, IL-6, urea and creatine in both the groups. Conclusion: In pregnancies complicated by PE with normal values of hemoglobin and hematocrit, serum prohepcidin concentrations are similar to those observed in healthy pregnant women. The analysis revealed no significant correlations between prohepcidin level and serum iron, serum ferritin or transferrin in the PE.
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    Relation of Anxiety and Depressive Symptoms with Perceived Social Support According to Gender within Infertile Couples
    (Yerkure Tanitim & Yayincilik Hizmetleri A S, 2015) Aldemir, Secil; Eser, Ayla; Turhan, Nilgun Ozturk; Dalbudak, Ercan; Topcu, Merve
    Relation of anxiety and depressive symptoms with perceived social support according to gender within infertile couples Objective: Evaluation of infertile couples' emotional symptoms and perceived social supports according to gender differences. Method: Hospital Anxiety and Depression Scale ( HADS) and Multidimensional Scale of Perceived Social Support (MSPSS) were administered to 66 primarily infertile couples that did not have psychiatric Axis-I disorders according to DSM-IV. Results: According to the scale's average points, the samples' depressive symptom levels did not indicate clinical depression; rather, anxiety levels were in normal ranges. Comparing participants' anxiety according to gender, female participants were more anxious than male participants. Couples reported less anxiety and depression as long as they perceived higher social support. It was found that the combined infertility group, in which both women and men have problems to conceive, had more perceived social support from significant other and friends than in the female-originated infertility group. Also, results revealed that the male-originated infertility group reported more perceived social support from significant other compared to the female-originated infertility group. Conclusion: Social support and emotional stress of females in infertile couples are more than males', and perceived sufficient social support decreases couples' emotional symptoms.