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Öğe Acute effects of caffeine on choroidal thickness and ocular pulse amplitude(Taylor & Francis Ltd, 2016) Dervisogullari, Mehmet Serdar; Totan, Yuksel; Yuce, Aslihan; Kulak, Ali EnderObjective: To explore ocular changes in healthy people after caffeine consumption.Methods: This prospective observational study was carried out with students of the Turgut ozal University Medical Faculty from May 15 to 15 December 2014. Enrolled in the study were 17 healthy subjects (n=17 eyes), with a median age of 24 (IQR 1), ranging between 21 and 26 years. The control group (6 females, 11 males) aged between 23 and 28 (median 25 years [IQR 4.75]). For study, one eye from each participant was randomly selected. To obviate the effect of diurnal variations, tests were performed at the same time of the day (10:00a.m.-12:00p.m.). Each subject was given an ophthalmologic examination before the study to exclude those with undiagnosed ocular disease. Version 6.0 Cirrus high-definition optical coherence tomography (HD-OCT) (Carl Zeiss Meditec, Dublin, CA) was used to measure CT at the fovea, and 1500m nasal and 1500m temporal to the fovea. After baseline OCT measurements, participants were asked to have 200mg oral caffeine intake or a placebo capsule (200mg lactose powder). Two further OCT measurements were applied at the first and fourth hours of caffeine intake. All participants also had intraocular pressure (IOP) and ocular pulse amplitude (OPA) measurements recorded before, first and fourth hours of caffeine intake. IOP and OPA were measured using the dynamic contour tonometry (DCT) (Swiss Micro Technology AG, Port, Switzerland).Results: The groups showed no significant difference by means of age, gender, spherical refraction and axial length (p>0.05). Baseline choroidal thickness measurements of the study and control group showed no significant difference. Oral caffeine intake caused a significant reduction in choroidal thickness compared with baseline, at all three measurement points, (p<0.05). There were no significant changes in IOP and OPA measurements compared with the baseline values (p>0.05). The choroidal thickness still continued to decrease for at least 4h following caffeine intake; whereas, the difference between 1 and 4h was not statistically significant (p>0.05). However, choroidal thicknesses, IOP and OPA values of the control group revealed no significant difference at all points when comparing measurements at baseline with 1 and 4h after placebo intake (p>0.05).Conclusions: We found no significant change in IOP and OPA following oral 200mg caffeine intake, while CT significantly decreased, for at least 4h.Öğe Brilliant Blue G assisted Epiretinal Membrane Surgery(Nature Portfolio, 2014) Totan, Yuksel; Guler, Emre; Dervisogullari, Mehmet SerdarWe report intensely staining epiretinal membrane (ERM) with Brilliant Blue G (BBG) under air for two minutes. ERM peeling was performed in 21 cases. After removal of posterior hyaloid, 0.2 mL BBG was first applied on the macula, to stain ERM under air conditions for 2 minutes. Internal limiting membrane (ILM) was intensely stained and peeled in all cases following ERM removal. In 4 cases, the ERM was also observed to be intensely stained with BBG and peeled with an ILM forceps. Postoperatively, the ganglion cell layer thickness was lower in three of the cases, however VA improved in all cases and multifocal electroretinogram revealed no toxicity. Light microscopy of ERM revealed masses of cells whereas; the ILM did not. The increased staining characteristics of ERM and ILM may be resulted from longer contact time of BBG under air pressure.Öğe Brilliant blue G assisted macular surgery: the effect of air infusion on contrast recognisability in internal limiting membrane peeling(Bmj Publishing Group, 2015) Totan, Yuksel; Guler, Emre; Guragac, Fatma B.; Uzun, Erkam; Dogdu, ErdoganBackground To evaluate the potential efficacy and safety of inner limiting membrane (ILM) staining with brilliant blue G (BBG) under air infusion. Methods 63 patients, treated by one surgeon with macular hole or idiopathic epiretinal membrane were evaluated prospectively. BBG was applied under air infusion in 38 patients (group 1), and injected into the vitreous cavity in 25 (group 2). Main outcome measures were the chromaticity difference between the stained ILM and the unstained underlying retina, anatomical-functional outcomes and complications of the surgery. Chromaticity difference was measured by an objective and quantitative analysis method to describe colour contrast strengths as they are perceived by the human eye. Anatomical and functional outcomes were assessed using optical coherence tomography (OCT), visual field analyses (VFA) and multifocal electroretinography (mfERG). Results CIELAB scores showed a significantly superior contrast for group 1 (16.72 +/- 2.36) than group 2 (10.34 +/- 1.29) (p<0.001). Visual acuity had increased in 28 eyes and remained stable in 10 eyes in group 1. In group 2, visual acuity had improved in 17 patients and remained unchanged in 8 patients. Based on postoperative OCT, anatomical success rate was 100%. During the follow-up period, mfERG and VFA demonstrated no case of BBG toxicity in either group. Cataract progression was the main postoperative complication (six eyes in group 1 and four eyes in group 2) and did not show a significant difference between the groups (p=0.45). Conclusions BBG under air infusion yields a significantly higher contrast staining and easy peeling of ILM associated with anatomical and functional improvement and no retinal toxicity after macular surgery.Öğe Choroidal thickness measurement in healthy pediatric population using Cirrus HD optical coherence tomography(Consel Brasil Oftalmologia, 2015) Tenlik, Aylin; Guragac, Fatma B.; Guler, Emre; Dervisogullari, Mehmet Serdar; Totan, YukselPurpose: To investigate the association between central choroidal thickness (CT), axial length (AL), age, gender, and refractive error in a healthy pediatric population using optical coherence tomography (OCT). Methods: This institutional study involved 137 healthy children (57 boys, 80 girls) aged between 4 and 18 years. Each child underwent a dilated eye examination, cycloplegic refraction, and AL measurement using a Nidek AL-Scan optical biometer. The central foveal thickness (CFT) and CT were measured using Cirrus high definition (HD)-OCT. The right eye of each subject was selected for analysis. Results: The mean age of the children was 10.0 +/- 4.7 years (range, 4-18 years). The mean spherical equivalent (SE) was -0.24 +/- 1.24 diopters (D) (range, -2.00 D to +/- 2.25 D). The mean AL was 23.1 +/- 1.2 mm (range, 20-27 mm). The mean central CT was 388.2 +/- 50.0 mu m and was not correlated with age, gender, AL, or refractive error. Conclusions: The data provide a pediatric normative database of CT using enhanced depth imaging OCT. This information may be useful in the diagnosis and monitoring of retino-choroidal diseases in children.Öğe Combined 20-and 23-gauge pars plana vitrectomy(Consel Brasil Oftalmologia, 2015) Totan, Yuksel; Guler, Emre[Abstract Not Available]Öğe Comparison of a new optical biometry with an optical low-coherence reflectometry for ocular biometry(Elsevier Science Bv, 2016) Guler, Emre; Kulak, Ali Ender; Totan, Yuksel; Yuvarlak, Armagan; Hepsen, Ibrahim FeyziObjective: To evaluate the repeatability and agreement of a new partial coherence interferometry optical biometer (AL-Scan, Nidek CO, Aichi, Japan) with optical low-coherence reflectometry device (Lenstar LS 900, Haag-Streit AG, Koniz, Switzerland). Methods: Three consecutive measurements with the 2 devices were performed by the same examiner in 65 eyes of 65 patients with cataract. Patients were divided into 2 groups: axial length (AL) between 22 and 26 mm (Group 1) and more than 26 mm (Group 2). Comparisons were performed for AL, anterior chamber depth (ACD), keratometry (K, over 2.4 mm diameter for AL-Scan and 2.3 mm diameter for Lenstar) and corneal diameter (CD). Repeatability was analyzed using the intraclass correlation coefficient (ICC) and the agreement was by the Bland-Altman method. Results: The repeatability of both devices was high for all biometry measurements (ICC over 0.970) in Group 1 and 2. The best repeatability was achieved for AL in each group. In both groups, the differences were statistically significant for all parameters (p < 0.05) except for the measurement of AL and CCT (p > 0.05). The Bland-Altman analysis showed good agreement between devices for all measurements in both groups. The closest agreement was for the AL measurements (ranged from -0.06 to 0.08 mm in Group 1 and 0.05-0.07 mm in Group 2). Conclusions: The new biometer provided excellent repeatability for all ocular biometry. In addition, there was good agreement between AL-Scan and Lenstar biometers for all parameters in cataractous patients with medium and long ALs. (C) 2016 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.Öğe Comparison of anterior chamber depth measurements of Nidek AL-Scan and Galilei Dual Scheimpflug Analyzer(Elsevier Science Bv, 2015) Dervisogullari, Mehmet Serdar; Totan, Yuksel; Guragac, BetulPurpose: We aimed to compare anterior chamber depth (ACD) measurements between the Nidek AL-Scan and the Galilei Dual Scheimpflug Analyzer. Setting: Turgut Ozal University Medical Faculty, Ankara, Turkey. Design: Prospective masked bilateral randomized study. Methods: Sixty-three individual patient eyes with normal ocular examination findings and no prior ocular surgery were analyzed. Paired two-tailed t-test was used to evaluate agreement between devices. Interobserver repeatability was evaluated in 22 patients using intraclass correlation coefficient (ICC) and Bland-Altman analysis. Results: The mean +/- standard deviation (+/- SD) ACD for Nidek and Galilei was 3.57 +/- 0.29 (range from 2.92 to 4.32) and 3.65 +/- 0.29 (range from 3.01 to 4.40), respectively. Comparing the two instruments using paired samples t-test, a statistically significant difference was found between the measurements obtained for ACD (P = 0). Two observers' intraclass correlation coefficients (ICC) were 0.996 for Nidek and 0.968 for Galilei. For Nidek, ACD mean difference was 0 mm (P < 0.001); 95% limits of agreement was from -0.05 to 0.05. For Galilei ACD mean difference was -0.01 mm (P < 0.001); 95% limits of agreement was from -0.14 to 0.12. The Galilei Dual Scheimpflug Analyzer measured longer ACD values than the Nidek AL-Scan. Conclusion: This comparative study showed that the difference in ACD between the measurements of the Nidek AL-Scan and the Galilei Dual Scheimpflug Analyzer was statistically significant but clinically it was negligible. Further studies are needed, especially on IOL calculation formulas that include ACD and its effect on postoperative spherical equivalent values. C) 2014 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.Öğe Cystoid Macular Edema Associated With Juvenile Idiopathic Arthritis Resolved by a Dexamethasone Intravitreal Implant(Slack Inc, 2014) Totan, Yuksel; Guler, Emre; Guragac, Fatma B.; Dervisogullari, Mehmet S.; Tenlik, Aylin; Hepsen, Ibrahim F.Uveitis, glaucoma, and cystoid macular edema frequently develop in patients with juvenile idiopathic arthritis. The authors describe a case of cystoid macular edema associated with juvenile idiopathic arthritis that had not responded to intravitreal triamcinolone acetonide and bevacizumab but improved significantly following intravitreal injection with a dexamethasone 0.7 mg implant.Öğe Dexamethasone Intravitreal Implant for Chronic Diabetic Macular Edema Resistant to Intravitreal Bevacizumab Treatment(Taylor & Francis Inc, 2016) Totan, Yuksel; Guler, Emre; Guragac, Fatma BetulPurpose: To evaluate the safety and efficacy of intravitreal dexamethasone implant (Ozurdex) in patients with chronic diabetic macular edema (DME) resistant to prior intravitreal bevacizumab (IVB) treatment. Materials and Methods: Thirty eyes of 30 patients were administered intravitreal Ozurdex and examined at baseline and 1, 3, and 6 months postinjection in this prospective study. Main outcomes were the best corrected visual acuity (BCVA, logMAR), central foveal thickness (CFT), mean cube volume (MCV), and intraocular pressure (IOP). Patients had a CFT over 275 mu m (measured by OCT) and were unresponsive to 3 consecutive IVB injections. All data are presented as meanstandard deviation. Results: The mean BCVA significantly increased from 0.56 +/- 0.38 to 0.41 +/- 0.27 (p<0.001), and 0.44 +/- 0.28 (p=0.008) at 1 and 3 months, respectively. At months 1, 3, and 6, the mean CFT significantly decreased from 517 +/- 136 mu m at baseline, to 290 +/- 60 mu m (p<0.001), 314 +/- 88 mu m (p<0.001) and 411 +/- 126 mu m (p=0.01), respectively. However, the mean CFT (p<0.001) and MCV (p=0.01) significantly increased and BCVA significantly decreased (p=0.04) at 6 month compared to 3 month. Compared to baseline, IOP increased significantly at 1 week (p=0.01), 1 month (p=0.01) and 3 months (p=0.04). However eyes with IOP higher than 21mmHg were treated and well controlled with topical anti-glaucoma monotherapy. Macular edema recurrence occurred in 25 eyes (CFT ranged from 321 mu m to 800 mu m) at 6 months. Conclusion: Dexamethasone intravitreal implant may be an effective and safe alternative in treatment of chronic DME nonresponsive to regular IVB. However, its therapeutic efficacy decreases between the third and sixth months following the injection.Öğe Effect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform layer complex(Taylor & Francis Ltd, 2015) Dervisogullari, Mehmet Serdar; Totan, Yuksel; Tenlik, Aylin; Yuce, Aslihan; Guler, EmrePurpose: The aim of this study is to show the effects of smoking on retina layers, especially retina nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer complex (GCIPL). Materials and methods: Participants smoking for more than 10 years at least 1 pack of cigarettes a day and a control group, both including participants between ages of 20 and 50 years with no other systemic or ocular diseases were studied. After normality tests, an independent sample t test was used to analyze the differences in age, sex, spherical equivalent (SE), intraocular pressure (IOP), axial length (AL), GCIPL and RNFL values between the groups. Results: There were 44 participants in each group. There were 32 (62.5%) men and 12(37.5%) women in smokers and 36 (77.88%) men and 8 (22.22%) women in control group. Mean ages were 39.85 +/- 8.41 and 38.66 +/- 10.47 years, mean spherical equivalent (SE) values were +/- 0.15 +/- 0.4 and 0 +/- 0.29 dioptries in smokers and control groups, respectively. The IOP, AXL, GCIPL and RNFL values were 17.58 +/- 3.41 mmHg, 23.69 +/- 0.56 mm, 84.3 +/- 5.83 mu m and 92.3 +/- 3.51 mu m in the smokers group and 18.5 +/- 2.91 mmHg, 23.45 +/- 0.72 mm, 86.11 +/- 8.02 mu m and 97.66 +/- 8.23 mu m in the control group. The inferior, superior, nasal and temporal values of RNFL quadrants were 123.18 +/- 26.14, 117.05 +/- 5.51, 64.95 +/- 8.67 and 63.5 +/- 6.88 mu m in the smokers group and 130.81 +/- 11.8, 123.55 +/- 11.03, 72.44 +/- 9.84 and 58.44 +/- 7.48 mu m in the control group. There were no significant difference of age, sex, SE, IOP, AXL and GCIPL values between the smokers and control groups (p>0.05). The mean RNFL was significantly thinner in the smokers group compared to controls (p = 0.03, independent t test). Inferior and superior quadrants of RNFL decreased in smokers group (p = 0.01 and p = 0.03, respectively) but temporal and nasal quadrants did not seem to be changed (p = 0.96 and p = 0.07, respectively). Discussion: Smoking may affect RNFL thickness but not GCIPL.Öğe Effects of cigarette smoking on choroidal and retinal thickness and ocular pulse amplitude(Taylor & Francis Ltd, 2015) Dervisogullan, Mehmet Serdar; Totan, Yuksel; Tenlik, Aylin; Yuce, AslihanBackground: In our study, we aimed to show the effects of smoking on choroidal thickness and ocular pulse amplitude. It is known that the anatomy and physiologic functions of the choroid is important in ocular diseases like glaucoma and age-related macular degeneration. Choroidal thickness is measured by the spectral domain optical coherence tomography (SD-OCT). The ocular pulse amplitude (OPA) is the difference between the systolic and diastolic intraocular pressure (IOP) and it is an index of choroidal perfusion. Design: This was a cross-sectional prospective observational study at the Turgut Ozal University Hospital setting. Participants: The test subjects were divided into two groups: the smokers group which consisted in 24 participants (20 male, 4 female) and the control group with 22 participants (16 male, 6 female). Methods: The participants underwent full ophthalmological examination including best-corrected visual acuity (BCVA), spherical equivalent (SE) values of refractive errors, intraocular pressure (IOP), ocular pulse amplitude (OPA), central corneal thickness (CCT), axial length (AL) and choroidal thickness. The IOP and the OPA were measured with the dynamic contour tonometer. The CCT and the AL were measured with the Nidek AL-Scan (Nidek Co., Ltd., Gamagori, Japan). The choroidal thickness was measured by the Cirrus high-definition optical coherence tomography (Cirrus Version 6.0; Carl Zeiss Meditec, Dublin, CA). Results: Gender did not differ significantly between the groups (p = 0.12). The age, SE, IOP, OPA, CCT and AL did not differ significantly in smokers and control groups (p = 0.12, p = 0.37, p = 0.54, p = 0.80, p = 0.56 and p = 0.82, respectively). The nasal, temporal, central retinal (p = 021, p = 021, p = 0.11) and nasal, temporal, central choroidal thicknesses (p = 0.80, p = 0.39, p = 0.75) did not differ significantly between smokers and control groups. Conclusions: We could not find a significant difference in OPA, retinal and choroidal thicknesses between smokers and non smokers. Further studies including histopathological changes in larger groups are needed to show the effect of smoking on choroidal thickness especially in patients with ocular diseases like age-related macular degeneration.Öğe Evaluation of Choroidal Thickness in Amblyopia Using Enhanced Depth Imaging Optical Coherence Tomography(Taylor & Francis Inc, 2015) Tenlik, Aylin; Guler, Emre; Kulak, Ali Ender; Totan, Yuksel; Dervisogullari, Mehmet Serdar; Guragac, Fatma BetulPurpose: To evaluate the choroidal thickness (CT) in hyperopic anisometropic amblyopic eyes, fellow non-amblyopic eyes, and age-matched normal eyes, using spectral-domain optical coherence tomography (SD-OCT). Materials and methods: In total 53 subjects (17.8 +/- 11.0 years, mean +/- SD) with hyperopic anisometropic amblyopia (AE) and 53 age-matched controls (17.7 +/- 11.0 years) were included in this prospective study. Each subject underwent a dilated eye examination, cycloplegic refraction and axial length (AL) measurement using Nidek AL-Scan optical biometer (Nidek CO, Aichi, Japan). The CT of subfoveal area and at a radius of 1 and 3mm around the fovea was determined using the enhanced depth imaging program of a SD-OCT (Cirrus HD OCT, Carl-Zeiss Meditec, Dublin, CA). CT, AL and spherical equivalent refraction (SER) of the amblyopic eyes were compared to that of the fellow and control eyes. Results: The mean subfoveal CTwas 305.6 +/- 26.0 mm in the amblyopic eyes, 282.6 +/- 30.7 mm in the fellow eyes and 280.1 +/- 8.8 in the control eyes. The subfoveal choroid in amblyopic eyes was significantly thicker than that of the fellow eyes and control eyes (p<0.001). There was a significant negative correlation between the subfoveal CT and the AL in amblyopic (r=-0.298, p=0.03) eyes but not in the control and fellow eyes. Conclusions: The subfoveal choroid of eyes with hyperopic AE is significantly thicker than that of the fellow eye and the age-matched controls. Hence, CT seems to be effected in AE.Öğe Evaluation of the Retinal Ganglion Cell Layer Thickness in Healthy Turkish Children(Lippincott Williams & Wilkins, 2015) Totan, Yuksel; Guragac, Fatma B.; Guler, EmrePurpose:To identify the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in healthy Turkish children measured by high-definition optical coherence tomography (HD-OCT).Patients and Methods:This institutional study involved 296 eyes from 296 healthy children aged between 3 and 17 years. Each child underwent a dilated eye examination, cycloplegic refraction, and axial length measurement using Nidek AL-Scan optical biometer. Macular scan was used to measure the GC-IPL thickness, and peripapillary retinal nerve fiber layer (RNFL) thickness was measured using the HD-OCT (Cirrus HD-OCT). Right eye of each subject was selected for analysis.Results:A total of 296 children (125 boys, 171 girls) were included in this study. The mean age of the children was 9.624.10 years (range, 3 to 17 y). The mean spherical equivalent was -0.09 +/- 1.49 D. The mean AL was 23.03 +/- 1.03 mm. The mean overall GC-IPL thickness was 83.44 +/- 5.52 m and RNFL thickness was 96.91 +/- 10.21 m. They were thicker than has been reported in adults. According to age-adjusted multiple regression analyses significant predictors of mean GC-IPL thickness were peripapillary RNFL thickness and AL (P<0.001).Conclusions:This study ensures a pediatric normative database of GC-IPL using spectral-domain OCT. This information may provide to diagnosis and monitoring of optic nerve diseases and glaucoma in children.Öğe Intravitreal bevacizumab and dexamethasone implant for treatment of chronic diabetic macular edema(Taylor & Francis Ltd, 2017) Guler, Emre; Totan, Yuksel; Guragac, Fatma BetulObjective: To evaluate anatomical and functional outcomes of intraviteal bevacizumab (IVB) in patients with chronic diabetic macular edema (DME), and the effectivity and safety of dexamethasone implant in those unresponsive to regular IVB treatment. Methods: Thirty-five eyes of 35 patients (16 male and 19 female) with chronic DME (central foveal thickness (CFT) >275m, duration >6 months) received three injections of 2.5mg IVB with six-week intervals. At 18 weeks, dexamethasone implant was applied to patients unresponsive to IVB. Main outcomes were the change in best corrected visual acuity (BCVA), CFT and ocular and systemic adverse effects for both drugs. The patients responsive to IVB were followed up for 36 weeks and those patients receiving dexamethasone implant were followed up for 24 weeks postoperatively. Results: At 18 weeks, the mean BCVA (0.68 +/- 0.40 logMAR, p=0.45) and CFT (453 +/- 169m, p=0.58) did not show any significant change compared to baseline (0.74 +/- 0.42 logMAR and 521 +/- 151m, respectively). In 20 patients (%57.1) responsive to IVB, the CFT was significantly improved from 12 to 36 weeks with the mean value of 295 +/- 42 (p=0.01). However, no significant difference was observed for BCVA during this period (p=0.17). Dexamethasone was implanted in 15 eyes (42.8%) unresponsive to IVB at 18 weeks. Statistically significant improvements were observed in BCVA (at postoperative 4 and 12 weeks) and CFT (at postoperative 4, 12 and 24 weeks). In addition, both parameters significantly worsened at 24 weeks compared to 12 weeks (p<0.001 and p=0.01, respectively). Conclusions: Patients with chronic DME should be followed in accordance with a fixed treatment protocol combining anti-VEGF and steroid treatments.Öğe Normative Spectral Domain Optical Coherence Tomography Data in Healthy Turkish Children(Taylor & Francis Inc, 2017) Guragac, Fatma Betul; Totan, Yuksel; Guler, Emre; Tenlik, Aylin; Ertugrul, Ihsan GokhanPurpose: To determine the normative database of macular and retinal nerve fiber layer (RNFL) thickness parameters in healthy Turkish children by OCT. Methods: 318 eyes of 318 children (138 boys, 183 girls) aged between 3 and 17 years were evaluated. The children were scanned by Cirrus HD-OCT (Carl Zeiss Meditec) to measure the macula, RNFL, and optic nerve head parameters. Results: Axial length (AL) (p <0.001, R-2 = 0.08), spherical equivalent (SE) (p < 0.001, R-2 = 0.12), and rim area (p <0.001, R-2 = 0.15) were the strongest predictors of RNFL thickness. All of the macular measurements were significantly related to age (p <0.001, R-2 > 5%). Average macular thickness (p < 0.01) and outer macula (p = 0.002) showed significant relationship with the AL and SE. Conclusion: This study ensures an age-adjusted pediatric normative database using OCT to diagnose and monitor macular diseases, optic nerve diseases, and glaucoma in children.Öğe The Efficacy and Safety of Valproic Acid in the Treatment of Retinitis Pigmentosa(Karger, 2014) Totan, Yuksel; Guler, Emre; Yuce, Aslihan; Dervisogullari, Mehmet Serdar[Abstract Not Available]Öğe Unilateral Spontaneous Descemet Membrane Rupture in a Case With Megalophthalmos(Lippincott Williams & Wilkins, 2018) Guler, Emre; Totan, Yuksel; Hepsen, Ibrahim F.; Tenlik, AylinObjective: To report a case of unilateral spontaneous descemet membrane rupture associated with megalophthalmos. Methods: A case report of a 23-year-old woman with blurred vision of the right eye for 6 months due to spontaneous descemet membrane rupture associated with megalophthalmos is described. Slit-lamp examination demonstrated corneal edema and suggestion of a descemet membrane rupture in the right eye. Results: Anterior segment optical coherence tomography verified the presence of a ruptured descemet membrane separated from the nasal posterior cornea along with corneal edema and intraepithelial cystic lesions. With A-scan ultrasonography, axial lengths were 32 and 28 mm in OD and OS, respectively. Indirect gonioscopy demonstrated a wide iridocorneal angle and a ciliary body band, bilaterally. Corneal pachymetry measurements were performed with Pentacam HR Scheimpflug topography which measured the central corneal thickness 360 mu in OD and 300 mu in OS. Conclusions: Megalophthalmos and spontaneous descemet membrane rupture are rare conditions. To the best literature knowledge, this is the first report of descemet membrane rupture in megalophthalmos.
