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    Choroid thickness and ocular pulse amplitude in migraine during attack
    (Nature Publishing Group, 2015) Dervisogullari, M. S.; Totan, Y.; Gencler, O. S.
    Aim To compare the choroidal thickness and ocular pulse amplitude (OPA) measurements obtained during the attack period in migraine patients and age and gender matched control group participants using high definition optical coherence tomography (OCT). Methods Thirty eyes at the side of the headache of 30 subjects with a diagnosis of migraine with or without aura and unilateral migraine and 29 age and gender matched healthy participants were enrolled in this observational, cross-sectional study. OCT scans were performed to all participants. Choroidal thicknesses were measured at the fovea, 1500 mm nasal and 1500 mm temporal to the fovea. Intraocular pressure (IOP) and OPA were also measured. Results The choroidal thickness measurements obtained during the attack period in migraine patients were (mean +/- SD) 279.82 +/- 35.87, 250.05 +/- 29.49, and 239.58 +/- 27.92 and in control group were 308.20 +/- 44.97, 276.95 +/- 41.39, and 281.60 +/- 41.38 at foveal, nasal, and temporal measurement points, respectively. Choroidal thickness significantly decreased according to the control group (P>0.05) at all measured points in migraine patients during attack. IOP (mean +/- SD) values were 16.71 +/- 3.26 and17.40 +/- 3.19 and OPA (mean +/- SD) values were 2.26 +/- 0.81 and 2.64 +/- 1.03 in migraine and control groups, respectively, and did not seem to be changed (P>0.05). Conclusions Choroidal thickness was found to be significantly decreased in unilateral migraine patients during the attack period when compared with the control group, whereas OPA did not change. The possible implications of these findings on the association between migraine and glaucoma are discussed.
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    Evaluation of ocular pulse amplitude and choroidal thickness in diabetic macular edema
    (Nature Publishing Group, 2016) Totan, Y.; Akyuz, T. K.; Guler, E.; Guragac, F. B.
    Purpose The aim of this study is to evaluate the ocular pulse amplitude (OPA) and choroidal thickness (CT) measurements in patients with diabetic macular edema (DME) and healthy subjects. Methods A total of 34 patients (12 male and 22 female) who had type 2 diabetes mellitus with DME and 34 sex-matched healthy subjects (13 male and 21 female) were included in this prospective study. The intraocular pressure (IOP) and OPA were measured with Dynamic contour tonometer (Pascal DCT, Switzerland). The subfoveal CT was measured using the Cirrus HD-OCT (Carl Zeiss Meditec). The CT at 1500 mu m and 3000 mu m nasal and temporal to the central fovea was also measured. Results The mean IOP values were 18.4 +/- 3.5 and 17.1 +/- 2.1mmHg in DME patients and healthy controls, respectively (P = 0.091). The mean OPA values in patients with DME (2.58 +/- 0.96) and controls (3.52 +/- 1.03) were statistically different (P < 0.001). The mean subfoveal CT value was 273.5 +/- 30.2 mu m in the eyes with DME and 321.4 +/- 36.5 mu m in the control group (P < 0.001). In both groups, linear regression analysis showed no significant association between OPA and CT measurements. The IOP showed a significantly positive correlation with OPA in both DME (P = 0.002, r = 0.526) and controls (P = 0.004, r = 0.483). Conclusions The current study suggests that both pulsatile choroidal blood flow and CT are decreased in patients with DME.