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    Are progranulin levels associated with polycystic ovary syndrome and its possible metabolic effects in adolescents and young women?
    (Springer Heidelberg, 2016) Ersoy, Ali Ozgur; Tokmak, Aytekin; Ozler, Sibel; Oztas, Efser; Ersoy, Ebru; Celik, Huseyin Tugrul; Erdamar, Husamettin
    Polycystic ovary syndrome (PCOS) is an important disease that may alter metabolic balances of the whole body. Progranulin is a growth factor which is related to epithelial, neuronal growth and oogenesis. Here, we aimed to investigate the diagnostic value of the levels of Progranulin in the clinical setting of PCOS, and its metabolic effects. Forty-one adolescents and young women with PCOS and 39 age and body mass index matched adolescents and young women as a control group who attended to the youth center of a tertiary referral center were included in this cross-sectional case-control study. Progranulin levels, indices of insulin sensitivity, lipidemic markers, metabolic syndrome (MetS) criteria were compared between the groups. Progranulin levels in patients with PCOS (7.48 +/- A 1.93 ng/mL) were significantly higher than in the control group (6.25 +/- A 1.98 ng/mL) (p = 0.006). Luteinizing hormone (LH) levels, LH/Follicle stimulating hormone (FSH) ratios, free testosterone, dehydroepiandrosterone sulfate (DHEAS), C-reactive protein (CRP) levels in patients with PCOS were significantly higher than in the control group (p < 0.05, for all). The MetS was present in 8 (19.5 %) of the patients in the study group and in 1 (2.3 %) of the patients in the control group (p = 0.029). There was significant inverse correlation between high-density lipoprotein cholesterol (HDL-C) and progranulin levels of patients diagnosed with PCOS (p = 0.008). Progranulin may be a novel biomarker for cardiovascular risk in patients with PCOS, thus these cases should be directed to close follow-up for possible cardiovascular diseases. Future larger studies should focus on this entity.
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    Evaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia
    (Taylor & Francis Ltd, 2016) Gokdemir, Irem Eda; Ozdegirmenci, Ozlem; Elmas, Burak; Sarikaya, Esma; Tokmak, Aytekin; Kazanci, Fatmanur H.; Gok, Sumeyye
    Objective: Pre-eclampsia is the result of impaired trophoblast invasion and spiral artery remodeling managed by inflammatory response in its etiology and physiopathology. The aim of this study was to compare serum molecules including IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels between pre-eclampsia and control groups and to investigate the role of these molecules in pre-eclampsia.Methods: Forty-one women diagnosed as pre-eclampsia between 30 and 40 weeks of gestation and 41 non-complicated pregnant women were enrolled in this cross-sectional, case-control prospective study. ELISA method was used to determine IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels within serums in two groups.Results: Serum ADAMTS12 and IL-33 levels were significantly lower in pre-eclampsia group (p<0.001 and p: 0.028, respectively), however, in sub-group analysis, no significant difference was observed (p>0.05). The cut-off value of ADAMTS12 levels to discriminate pre-eclampsia with %73.17 sensitivity and %92.68 specificity was 8.27ng/ml while the cut-off value for IL-33 was 0.23pg/ml with 82.93% sensitivity and 53.66% specificity.Conclusion: Pre-eclampsia is associated with lower serum IL-33 and ADAMTS12 levels.
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    Increased levels of serum granzyme-B is associated with insulin resistance and increased cardiovascular risk in adolescent polycystic ovary syndrome patients
    (Elsevier, 2016) Oztas, Efser; Ozler, Sibel; Tokmak, Aytekin; Yilmaz, Nafiye; Celik, Huseyin Tugrul; Kazanci, Fatmanur Hacievliyagil; Danisman, Nuri
    Objectives: Our aim was to determine serum perforin and granzyme-B levels in adolescent PCOS patients, and to investigate whether they are associated with some of the insulin sensitivity, obesity and cardiovascular (CV) risk markers and metabolic syndrome. Study design: A case-control study was carried out including a total of 172 adolescents (83 PCOS patients and 89 age-matched healthy controls). Participants were recruited consecutively. Homeostasis model assessment (HOMA-IR), lipid parameters, and anthropometric measurements were determined. Serum perforin and granzyme B levels were measured by commercially available ELISA kits. HOMA-IR > 3.16 was considered to indicate the presence of insulin resistance. Logistic regression analysis was applied for the predictive value of granzyme-B for increased CV risk in PCOS patients. Results: As body mass index (BMI) of the PCOS patients was significantly higher than the controls (median 24.6 kg/m(2) and 21.4 kg/m(2), respectively, p < 0.001) all parameters were evaluated after adjustment for BMI. Adolescents with PCOS had significantly higher levels of fasting glucose, insulin, HOMA-IR and granzyme-B when compared with controls. According to the results of logistic regression analysis, granzyme-B levels were found to be significantly associated with increased HOMA-IR (OR = 6.120, 95% CI: 2.352-15.926, p < 0.001) in adolescent PCOS patients. Additionally, elevated levels of serum granzyme-B were predictive for increased CV risk in PCOS patients (OR = 0.237, 95% CI: 0.091-0.616, p = 0.003). Conclusions: Increased levels of serum granzyme-B are independently associated with insulin resistance and also with increased CV risk in adolescent polycystic ovary syndrome patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.