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    DOES CABERGOLINE USING IN OHSS TREATMENT AFFECT ON IMPLANTATION INFLUENCING VEGF LEVELS IN ENDOMETRIUM OF RATS?
    (Elsevier Science Inc, 2015) Yilmaz, N.; Yilmaz, S.; Inal, H. A.; Timur, H.; Haltas, H.
    [Abstract Not Available]
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    THE EFFECTS OF FORMOTEROL ON THE SERUM, PERITONEAL VEGF, AND MDA AND VEGF LEVELS IN THE OVARIES AND ENDOMETRIUM OF RATS WITH OHSS
    (Elsevier Science Inc, 2015) Inal, H. A.; Inal, Z. O.; Yilmaz, N.; Timur, H.; Oruc, A. Sargin; Kalem, M. N.; Han, O.
    [Abstract Not Available]
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    The effects of formoterol on the serum, peritoneal VEGF, MDA, and VEGF levels in the ovaries and endometrium of rats with OHSS
    (I R O G Canada, Inc, 2017) Inal, H. A.; Inal, Z. H. Ozturk; Yilmaz, N.; Timur, H.; Oruc, A. S.; Kalem, M. N.; Han, O.
    Purpose: To investigate the effects of formoterol (a beta2-adrenoreceptor agonist) on serum and peritoneal fluid VEGF, malondialdehyde (MDA) levels, and on VEGF-stained cell counts in the ovaries and endometrium of rats with ovarian hyperstimulation syndrome (OHSS) within the framework of immunohistochemical analysis. Materials and Methods: A total of 28 immature female Wistar rats were randomly divided into four groups. Three groups were given ten IU pregnant mare serum gonadotropin/day on days 22-25 of life. They were administered 30 IU hCG on day 26 of life to mimic OHSS. On days 26 and 27 of life, 24 mcg/kg/day formoterol in group 3 and 48 mcg/kg formoterol in group 4 were administered intraperitoneally per animal. Results: Although, there were no statistically significant differences between the groups in terms of serum and peritoneal fluid VEGF or MDA levels (serum VEGF: p = 0.281, peritoneal VEGF: p = 0.674, serum MDA: p = 0.543, peritoneal MDA: p = 0.506), there was a significant difference between the control and the OHSS placebo groups (p = 0.013) regarding the VEGF in the ovarian cortex. There was a significant difference between the control and the other groups in terms of ovarian stroma (p = 0.001), and there was also a statistically significant difference between the OHSS placebo and the other groups regarding VEGF in the endometrium (OHSS placebo vs. control group p = 0.002, OHSS placebo vs. the formoterol 24 mcg/kg group, p = 0.008, and OHSS-placebo vs. the formoterol 48 mcg/kg group, p = 0.001). Conclusions: Formoterol represents a potential novel strategy for the management of OHSS. Further studies, including those examining the dosage of formoterol, are warranted.