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Öğe Epicardial adipose tissue and pericoronary fat thickness measured with 64-multidetector computed tomography: potential predictors of the severity of coronary artery disease(Hospital Clinicas, Univ Sao Paulo, 2014) Demircelik, Muhammed Bora; Yilmaz, Omer Caglar; Gurel, Ozgul Malcok; Selcoki, Yusuf; Atar, Inci Asli; Bozkurt, Alper; Akin, KayihanOBJECTIVE: The aim of the present study was to investigate the relationship between pericoronary fat and the severity and extent of atherosclerosis, quantified using 64-multidetector computed tomography, in patients with suspected coronary artery disease. METHODS: The study population consisted of 131 patients who were clinically referred for noninvasive multislice computed tomography coronary angiography for the evaluation of coronary artery disease. Patients were classified as follows: no atherosclerosis, Group 1; nonobstructive atherosclerosis (luminal narrowing <50% in diameter), Group 2; and obstructive atherosclerosis (luminal narrowing >= 50%) in a single vessel or obstructive atherosclerosis in the left main coronary artery and/or multiple vessels, Group 3. Epicardial adipose tissue was defined as the adipose tissue between the surface of the heart and the visceral layer of the pericardium (visceral epicardium). Epicardial adipose tissue thickness (mm) was determined in the right ventricular anterior free wall. The mean thickness of the pericoronary fat surrounding the three coronary arteries was used for the analyses. RESULTS: The average thickness over all three regions was 13.2 +/- 2.1 mm. The pericoronary fat thickness was significantly increased in Group 3 compared with Groups 2 and 1. The epicardial adipose tissue thickness was significantly increased in Group 3 compared with Groups 2 and 1. A receiver operating characteristic curve for obstructive coronary artery disease was assessed to verify the optimum cut-off point for pericoronary fat thickness, which was 13.8 mm. A receiver operating characteristic curve for obstructive coronary artery disease was also assessed to verify the optimum cut-off point for epicardial adipose tissue, which was 6.8 cm. CONCLUSION: We showed that the epicardial adipose tissue and pericoronary fat thickness scores were higher in patients with obstructive coronary artery diseases.Öğe Galectin-3: A biochemical marker to detect paroxysmal atrial fibrillation?(Canadian Soc Clinical Investigation, 2016) Selcoki, Yusuf; Aydin, H. Ibrahim; Celik, Tugrul H.; Isleyen, Ahmet; Erayman, Ali; Demircelik, M. Bora; Demirin, HilmiPurpose: Atrial fibrillation (AF) is the most common form of arrhythmia. AF leads to electrical remodelling and fibrosis of the atria; however, the mechanism(s) remain poorly understood. Galectin-3 is a potential mediator of cardiac fibrosis. The present study aimed to examine the relationship between serum galectin-3 levels and paroxysmal AF. Methods: Forty-six patients with paroxysmal AF and preserved left ventricular systolic function, and 38 age-and gender-matched control subjects, were involved in the study. Serum galectin-3 levels were analyzed with an enzyme-linked immunosorbent assay (ELISA). Results: Serum galectin-3 levels (median 1.38 ng/mL; 1.21 ng/mL-1.87 ng/mL; p < 0.001) were significantly elevated in patients with paroxysmal AF compared with the control. Left atrial diameter was significantly higher in patients with paroxysmal AF (41.2 +/- 3.0 mm vs. 39.6 +/- 3.3 mm). Left atrial diameter was found to be significantly correlated with serum galectin-3 levels in patients with paroxysmal AF (r= 0.378, p = 0.001). Conclusion: Serum galectin-3 levels are significantly elevated and significantly correlated with left atrial diameter in patients with paroxysmal AF.Öğe Hand and heart, hand in hand: is radiological hand osteoarthritis associated with atherosclerosis?(Wiley, 2014) Cemeroglu, Ozlem; Aydin, Halil I.; Yasar, Zeynep S.; Bozduman, Fadime; Saglam, Mustafa; Selcoki, Yusuf; Eryonucu, BeyhanAimIncreasing evidence suggests that atherosclerosis contributes to the initiation or progression of osteoarthritis (OA). It has been suggested that atherosclerosis may cause vascular insufficiency which may lead to or progress OA. In this study, the association between the severity of radiologic hand OA and atherosclerosis was analyzed in women. MethodsSixty-one women, 50years of age, free of hand symptoms were enrolled in the study. Postero-anterior views of both hands were obtained using digital radiography. A total of 14 joints were assessed for radiographic OA according to Kellgren/Lawrence (K/L) score. An OA-affected joint was defined as K/L score of 2. Hand OA was defined as 3 joints of both hands affected with OA and severity of hand OA was defined as total K/L scores of all 14 joints of both hands. Gensini scoring was used to evaluate the patients for atherosclerosis severity. ResultsThe patient characteristics such as presence of diabetes, smoking, hypertension, dyslipidemia and medications used were similar for patients with and without hand OA (P>0.05) and did not correlate with Gensini or hand OA scores. The mean Gensini scores of patients with hand OA was 21.517.1 and without hand OA was 11.8 +/- 9.2 (P=0.017). The degree of osteoarthritic joint involvement and Gensini scores showed a positive correlation (r=0.332, P=0.009). ConclusionHand OA may be a benign clinical finding that may suggest a possible serious underlying atherosclerosis. Patients with significant hand OA should be screened for atherosclerosis to prevent serious coronary artery disease and related comorbidities.Öğe Is Radiological Hand Osteoarthritis Associated with Atherosclerosis?: A Cross-Sectional Study in Turkish Women(Elsevier Science Inc, 2013) Demircelik, Muhammed Bora; Aydin, Halil Ibrahim; Cemeroglu, Ozlem; Yasar, Zeynep Sila; Gurel, Ozgul Malcok; Bozduman, Fadime; Selcoki, Yusuf[Abstract Not Available]
