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Structural Changes in the Cerebrum, Cerebellum and Corpus Callosum in Migraine Patients
(Canadian Soc Clinical Investigation, 2016) Demir, Berin T.; Bayram, Nezihe A.; Ayturk, Zubeyde; Erdamar, Husamettin; Seven, Pelin; Calp, Aysegul; Sazak, Merve
Purpose: The purpose of this study was to demonstrate the relationship among the cerebrum, cerebellum and corpus callosum in migraine patients. Methods: This work was conducted with cooperation of the Turgut Ozal Medical Faculty, Department of Anatomy and Neurology. Migraine patients were divided into four groups: new patients; 1-5 years; 5-10 years; and, more than 10 years. All patients (n=75) and control subjects (n=20) underwent Magnetic Resonance Imaging (MRI) and brain images were processed by ONIS and Image J. Data were analyzed using the planimetric method. Results: Cerebrum, cerebellum and corpus callosum volume were calculated for all subjects. The footprints of the callosum were as follows: healthy control subjects, new patients and 1-year patients: 12.8%, 5 years: 11.7% and more than 10 years: 10.7%. The cerebrum volume was as follows: healthy control subjects: 1152 cm(3), 5-10 years: 1102 cm(3) and more than 10 years: 1002 cm(3). Discussion: The results of our study showed atrophy in the cerebrum, cerebellum and corpus callosum of chronic migraine patients. This atrophy was greater in the patients with aura migraines. Conclusion: Our study confirmed that a migraine is an episodic disease that seriously affects the CNS.