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    A new biological marker candidate in female reproductive system diseases: Matrix metalloproteinase with thrombospondin motifs (ADAMTS)
    (Galenos Yayincilik, 2014) Demircan, Kadir; Comertoglu, Ismail; Akyol, Sumeyya; Yigitoglu, Beyza Nur; Sarikaya, Esma
    Playing a key role in the pathophysiology of many diseases, A Disintegrin-like and Metalloproteinase with Thrombospondin type-1 motif (ADAMTS) proteinases have been attracted more attention in obstetrics and gynecology. First discovered in 1997, this zinc-dependent proteinase family has 19 members today. These enzymes, which are located in the extracellular matrix (ECM), have a lot of very important functions, like matrix formation and resorption, angiogenesis, ovulation, and coagulation. In addition, in the pathogenesis of cancer, inflammation, arthritis, and connective tissue diseases, ADAMTS proteinases have crucial roles. The purpose of this review is to collect previous studies about obstetrics and gynecology that are related to ADAMTS enzymes and discuss the subject in many aspects to give an idea to the investigators who are interested in the subject.
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    Öğe
    Evaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia
    (Taylor & Francis Ltd, 2016) Gokdemir, Irem Eda; Ozdegirmenci, Ozlem; Elmas, Burak; Sarikaya, Esma; Tokmak, Aytekin; Kazanci, Fatmanur H.; Gok, Sumeyye
    Objective: Pre-eclampsia is the result of impaired trophoblast invasion and spiral artery remodeling managed by inflammatory response in its etiology and physiopathology. The aim of this study was to compare serum molecules including IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels between pre-eclampsia and control groups and to investigate the role of these molecules in pre-eclampsia.Methods: Forty-one women diagnosed as pre-eclampsia between 30 and 40 weeks of gestation and 41 non-complicated pregnant women were enrolled in this cross-sectional, case-control prospective study. ELISA method was used to determine IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels within serums in two groups.Results: Serum ADAMTS12 and IL-33 levels were significantly lower in pre-eclampsia group (p<0.001 and p: 0.028, respectively), however, in sub-group analysis, no significant difference was observed (p>0.05). The cut-off value of ADAMTS12 levels to discriminate pre-eclampsia with %73.17 sensitivity and %92.68 specificity was 8.27ng/ml while the cut-off value for IL-33 was 0.23pg/ml with 82.93% sensitivity and 53.66% specificity.Conclusion: Pre-eclampsia is associated with lower serum IL-33 and ADAMTS12 levels.