Yazar "Sahiner, Enes" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis
    (Taylor & Francis Ltd, 2014) Yilmaz, Hakki; Gurel, Ozgul Malcok; Celik, Huseyin Tugrul; Sahiner, Enes; Yildirim, Mehmet Erol; Bilgic, Mukadder Ayse; Bavbek, Nuket
    Purpose: The aim of this study was to analyze associations between serum cancer antigen 125 (CA 125) levels and left ventricular (LV) function in patients with end-stage renal disease on maintenance hemodialysis (HD). Methods: CA 125 levels, pro-brain natriuretic peptide (pro-BNP) and biochemical parameters were measured, and echocardiography was performed for 110 patients and 47 healthy controls. Results: The mean CA 125 level in patients, 38.78 +/- 35.48 U/mL, was significantly higher than that found in healthy controls (9.20 +/- 4.55 U/mL; p = 0.003). Patients with elevated CA 125 levels (n = 40) had significantly lower levels of albumin and reduced relative wall thickness, LV ejection fraction (EF) and fractional shortening but significantly higher levels of pro-BNP and a greater left ventricular end-diastolic diameter (LVEDd) and -systolic diameter (LVESd). CA 125 levels were positively correlated with pro-BNP (r = 0.596, p<0.05) and C-reactive protein (CRP) levels (r = 0.439, p<0.05), as well as LVEDd (r = 0.599, p<0.001), LVESd (r = 0.750, p<0.001) and LV mass index (r = 0.378, p<0.05). In contrast, serum CA 125 levels were negatively correlated with albumin (r = -0.513, p<0.05) and hemoglobin (r = -0.475, p<0.05) as well as the EF (r = -0.878, p<0.0001). A depressed EF (beta = -1.121, p<0.0001) and increased CRP levels (beta = 0.247, p = 0.035) were independent predictors of high CA 125 levels in the whole group in the multivariate-model. Conclusions: Our study is the first to demonstrate an association between serum CA 125 levels and LV systolic dysfunction via inflammation in patients on maintenance HD.
  • Küçük Resim Yok
    Öğe
    Circulating irisin levels reflect visceral adiposity in non-diabetic patients undergoing hemodialysis
    (Taylor & Francis Ltd, 2016) Yilmaz, Hakki; Cakmak, Muzaffer; Darcin, Tahir; Inan, Osman; Sahiner, Enes; Demir, Canan; Aktas, Aynur
    Background: Recent evidence suggests that increased visceral adiposity is a strong independent risk factor for cardiovascular death and all-cause mortality in hemodialysis (HD) patients. Irisin, which is a novel myokine, can play critical roles in diabetes and adiposity. The purpose of our study was to investigate whether serum irisin levels are associated with body mass index, waist circumference (WC), and total fat mass in non-diabetic patients undergoing maintenance HD.Methods: This cross-sectional study included 108 non-diabetic HD patients and 40 age- and sex-matched apparently healthy subjects. Serum irisin concentrations were determined using an enzyme-linked immunosorbent assay. Body fat composition (TBF-410 Tanita Body Composition Analyzer) was measured and calculated.Results: Serum irisin levels did not differ between HD patients and the healthy controls (523.50 +/- 229.32 vs. 511.28 +/- 259.74, p=0.782). Serum irisin levels were associated with age (r=0.314; p=0.006), HOMA-IR (r=0.472; p=0.003), WC (r=0.862; p<0.001), and total fat mass (r=0.614; p<0.001). In multivariate regression analysis, WC (=1.240, p<0.001) and total fat mass (=0.792, p=0.015) were the variables that were significantly associated with irisin concentrations (R-2=0.684, p<0.001) after adjusting for confounding factors (age and HOMA-IR). Conclusions: These results suggest that serum irisin levels are related to visceral adiposity in non-diabetic HD patients.