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Öğe Evaluation of organ weights and ventricular thicknesses in electrocution related deaths based on autopsy reports: A biophysical approach(Pakistan Medical Assoc, 2023) Kilinc, Evren; Ozturk, Onur; Oruc, Mucahit; Celbis, OsmanObjective: To evaluate autopsy reports of the deaths due to electrocution in terms of body mass index, body surface area, and organ weights with a biophysical perspective. Method: The retrospective study was conducted in Malatya, Turkiye, and comprised autopsy reports of electrocution cases that were obtained from the local branch of the Council of Forensic Medicine related to the period from 2012 to 2019. Organ weights and ventricular thicknesses were compared in terms of body mass index and body surface area. Electrical marks were also evaluated in detail. Data was analysed using SPSS 18. Results: Of the 45 cases, 36(%) were male and 9(%) were female. The overall mean age was 39 +/- 13 years (range: 20-71 years). There were no significant differences in organ weights and ventricular thicknesses in different body mass index groups (p>0.05). The weights of head and heart were significantly different in relation to body surface area (p<0.05), but no significant difference were found for other organs and ventricular thickness (p>0.05). Conclusion: Comparing the organ weights in electrocution autopsies to normal organ weights may help decide the cause of death. During autopsy, electrical marks should be evaluated by considering the characteristics of the electrical current.Öğe Investigation of the Relationships Between IL-12B and IL-23 Receptor Polymorphisms with Behçet's Disease in a Turkish Population(Mdpi, 2026) Arikan, Sanem; Ozturk, Onur; Atalay, Ayfer; Atalay, Erol OmerBeh & ccedil;et's disease is a chronic, multisystem inflammatory disorder characterized by recurrent mucocutaneous and ocular manifestations, in which genetic factors, particularly cytokine gene polymorphisms, are thought to contribute to disease susceptibility. This study aimed to investigate the association of Interleukin-12B and Interleukin-23R gene polymorphisms and haplotype distributions with Beh & ccedil;et's disease in Denizli, a province of Turkey. A total of 88 patients with Beh & ccedil;et's disease and 133 healthy controls were genotyped for Interleukin-12B (rs3213119, rs3213120, rs3212227, rs3213113, rs2082412) and Interleukin-23R (rs1004819, rs7517847, rs7530511, rs10489629, rs10889677) polymorphisms using polymerase chain reaction-restriction fragment length polymorphism analysis. Genotype, allele, and haplotype distributions were evaluated for associations with Beh & ccedil;et's disease risk and clinical manifestations. The results demonstrated that the Interleukin-12B rs2082412 G allele and rs3213119 G allele were associated with increased risk of Beh & ccedil;et's disease. Additionally, the Interleukin-23R rs7530511 TT genotype and rs10489629 GG genotype and G allele were significantly associated with Beh & ccedil;et's disease susceptibility. Haplotype analyses revealed AAAGG and GTCAC as the most frequent haplotypes in Interleukin-12B and Interleukin-23R loci, respectively, in both patients and controls. These findings suggest that Interleukin-12B and Interleukin-23R gene polymorphisms and haplotypes may be associated with Beh & ccedil;et's disease susceptibility and clinical heterogeneity in this population.Öğe Molecular docking reveals fibrinogen binding sites on SARS-CoV-2 spike protein: A potential mechanism for COVID-19-related coagulation(2024) Ozturk, Onur; Kilinç, Evren; İrez, Batuhan Görkem; Timucin, EmelThe Coronavirus Disease (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2), highlighted significant gaps in our understanding of the virus’s molecular structure, its biological properties, and the interactions between viral proteins and host biological systems, which have underscored the critical need for further research in this area. Coagulation disorders, particularly those leading to thromboinflammation, have been linked to severe complications in COVID-19 cases. The occurrence of thromboinflammation has likewise been corroborated in cases of both Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). In this study, we investigated the protein-protein interactions between the SARS-CoV-2 spike protein and fibrinogen, a glycoprotein that plays a crucial role in blood coagulation. Molecular docking analysis revealed key interactions between the ? and ? subunits of fibrinogen and the spike protein. The findings suggest that these interactions may contribute to the understanding of the coagulation disorders observed in COVID-19 patients. This study provides insights into the molecular mechanisms underlying these disorders and identifies potential targets for the development of therapeutic interventions.Öğe Network analysis of beta gene (HBB) haplotypes related to Hb S (β6 Glu → Val) in Denizli, Turkiye(Pakistan Medical Assoc, 2025) Ozturk, OnurNumerous haplotypes related to the haemoglobin S mutation have been diagnosed worldwide and in the Denizli region of T & uuml;rkiye. These subgroup haplotypes include Benin, Arab-Indian, Senegal, Bantu, Algeria, Cameroon, Central African Republic, Saudi and various other varieties. The current study was planned to determine the formation periods and network linkage relationships of genetic variations linked to haemoglobin S in the Denizli area and other geographical regions. The haplotype data was processed using Network software to calculate possible links between haplotypes and their formation dates. The results uphold the possibility that the haemoglobin S mutation may have come to the area through migratory pathways. According to analysis, the Benin haplotype historically formed first, followed by the Senegal and Arab-Indian haplotypes. These findings indicate that the haemoglobin S mutation might have reached the Mediterranean area long before the Silk Route migrations approximate to 2,000 years ago.Öğe Protein structure analysis of abnormal hemoglobins; Hb D-Los Angeles, Hb S and Hb G-Coushatta(2024) Ozturk, OnurComputational methods have been extensively utilized for protein structure prediction and modeling, including hemoglobin. These methods have provided valuable insights into the three-dimensional conformation of hemoglobin, its allosteric regulation, and its oxygen-binding capacity. For instance, computational modeling has been employed to understand the structural mechanism of hemoglobin, shedding light on the equilibrium between alternative structures, like the tense (T) and relaxed (R) states, which influence oxygen affinity and binding. Abnormal hemoglobins are associated with various genetic and clinical implications. The mutations in the globin genes to cause changes in the molecular structure of hemoglobin, affecting its biological properties such as oxygen carrying capacity and stability. RMSD is the mean displacement of atoms or molecular structures. Therefore, RMSD is a preferred parameter in structural similarity modeling studies. RMSD values calculated for pairwise protein structures are Hb A (Normal Hb)-Hb D-Los Angeles 3.44 Å, Hb A-Hb S 3.339 Å, Hb A-Hb G-Coushatta 3.35 Å. The aim of this study is to discuss the possible structural and electrical properties of abnormal haemoglobin molecules using protein modelling.
