Yazar "Noma, Samir Abbas Ali" seçeneğine göre listele

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    Melatonin protects sperm cells of Capoeta trutta from toxicity of titanium dioxide nanoparticles
    (Springer, 2020) Özgür, Mustafa Erkan; Ulu, Ahmet; Noma, Samir Abbas Ali; Özcan, İmren; Balcıoğlu, Sevgi; Ateş, Burhan; Köytepe, Süleyman
    In this study, it was aimed to determine the protective effects of melatonin (0.01, 0.1, and 1 mM) against 10 mg/L titanium dioxide nanoparticles (TiO2-NPs) on kinematic and oxidative indices in the sperm cells of Capoeta trutta. Therefore, TiO2 nanoparticles were synthesized primarily within the scope of the study. The synthesized nanoparticles were characterized by structurally different techniques. Then, melatonin and TiO2 were applied to Capoeta trutta sperm cells by in vitro. According to our data, all doses of melatonin showed protective effects on all velocities of sperm cells such as the straight line velocity (VSL), the curvilinear velocity (VCL), and the angular path velocity (VAP) against TiO2-NPs, while 0.1 and 1 mM doses of melatonin improved the VSL value. Although TiO2-NPs increased total glutathione (tGSH), malondialdehyde (MDA) lipid peroxidation, and superoxide dismutase (SOD) compared to the control group, there were positive treatment effects for all doses of melatonin on antioxidant capacity of sperm cells. At the end of this research, it is suggested that over 0.1 mM dose of melatonin improves the velocity of sperm cells and it plays a protective role against the toxic effects of TiO2-NPs.
  • Küçük Resim
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    A study about excellent xanthine oxidase inhibitory effects of new pyridine salts
    (Springer, 2021) Yılmaz, Ülkü; Noma, Samir Abbas Ali; Taşkın Tok, Tuğba; Şen, Betül; Gök, Yetkin; Aktaş, Aydın; Ateş, Burhan; Aygün, Muhittin
    A series of pyridine salts were synthesized containing vitamin B3 (niacin), isonicotinonitrile, and non-substituted pyridine fragment from reactions of 1,3-dibromopropane, 1,4-dibromobutane, and 4,4?-bis(chloromethyl)-1,1?-biphenyl reactants with pyridines. The builds of pyridine salts were identified by dint of IR, 1H, and 13C NMR spectroscopic techniques, and CHN analyses. Therewithal, the build of a compound was assigned via the X-ray single-crystal diffraction method. 1,3-Bis(3-cyanopyridine-1-ium-1-yl)propane dibromide crystallizes in the orthorhombic space group Ccce, with half of the cation molecule and one bromide anion in the asymmetric unit. Enzyme inhibitory properties of pyridine compounds were tested on the activities of xanthine oxidase (XO) and determined in the range from 0.394 to 0.623 ?M. All of the compounds inhibited enzyme more effectively than allopurinol that which is a standard drug. In addition, docking calculations were applied to investigate the binding properties and interactions of pyridine salts towards XO.