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Öğe Acute lower gastrointestinal bleeding originating from an arteriovenous fistula of superior rectal artery(Springer, 2014) Bozkurt, Alper; Sozen, Meral; Kirbas, Ismail; Bilgic, Ismail; Kasapoglu, Benan; Nadir, Isilay[Abstract Not Available]Öğe Endoscopic and Mucosal Healing in Crohn's Disease with Azathioprine(Derman Medical Publ, 2016) Nadir, Isilay; Kafadar, Mehmet Tolga; Kasapoglu, Benan[Abstract Not Available]Öğe Gastrointestinal stromal Tumor with mesenteric Localization Fistulized to Proximal Jejunum Causing Massive Rectal Bleeding(Derman Medical Publ, 2016) Kafadar, Mehmet Tolga; Nadir, Isilay; Bozer, MikdatGastrointestinal stromal tumors (CISTs) are the most common mesenchymal tumors of the gastrointestinal system. These non-epithelial tumors originate from the muscularispropria layer of the wall of the gastrointestinal tract Their most common locations of origin are the stomach and small intestine Rarely, they may originate from the retroperitoneum or abdomen. and may have no connection with the gastrointestinal system. They are usually incidentally detected in endoscopic and radiological examinations of the gastrointestinal system or during surgical treatment of emergency conditions such as hemorrhage, obstruction, or organ perforation. In this paper, we report a 59-year-old man with GIST located in the proximal jejunum that caused massive bleeding owing to its rarely encountered location. Histopathological examination made the definitive diagnosis, and the patient underwent total excision of the Pass and the resection of a 20-cm jejunal segment.Öğe Laparoscopic Nissen fundoplication with mesh-hiatoplasty: Single center experience and early-term results(Canadian Soc Clinical Investigation, 2016) Kafadar, Mehmet Tolga; Yalaza, Metin; Turkan, Ahmet; Surgit, Onder; Degirmencioglu, Gurkan; Nadir, IsilayPurpose: In this study we report early-term results of laparoscopic Nissen fundoplication with mesh hiatoplasty that we perform to treat gastroesophageal reflux disease. Methods: We retrospectively reviewed the medical records of 68 patients who underwent laparoscopic Nissen fundoplication with mesh hiatoplasty at our clinic. Thirty-six (53%) patients were male and 32 (47%) were female. The mean age of the study population was 46.1 (25-72) years. All patients underwent endoscopy, esophagus pH metry and manometry before the operation. All operations were performed under general anesthesia using five ports. In addition to Nissen fundoplication, all patients also underwent polypropylene mesh placement. Results: Preoperatively, all patients reported a burning sensation in the chest and regurgitation of the stomach contents up into the mouth. The mean time from symptom onset to operation was 28 (6-84) months. All patients were diagnosed with esophagitis in the preoperative endoscopic examination. The mean operative time was 80 (40-125) minutes, the median duration of hospital stay was 1.2 (1-4) days and the median follow- up time was 12 (2-30) months. Functional outcome was excellent in 65% of patients, good in 24.5%, moderately good in 7% and poor in 3.5%. Conclusion: Fundoplication with mesh hiatoplasty is a surgical procedure performed for the traetment of gastroesophageal reflux disease and hiatal hernia. Surgery can be safely carried out with low morbidity and mortality rates and constitutes an alternative to long-term drug therapy. We believe that this operation is beneficial since it reduces the rate of recurrences to a significant degree.Öğe Neutrophil-Lymphocyte Ratio (NLR) Could Be Better Predictor than C-reactive Protein (CRP) for Liver Fibrosis in Non-alcoholic Steatohepatitis(NASH)(Assoc Clinical Scientists, 2015) Yilmaz, Hakki; Yalcin, Kadir Serkan; Namuslu, Mehmet; Celik, Huseyin Tugrul; Sozen, Meral; Inan, Osman; Nadir, IsilayBackground-Aim. Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide. The aims of this study were to assess Neutrophil-Lymphocyte Ratio (NLR) and C-reactive protein (CRP), and their association with liver histology in patients with non-alcoholic steatohepatitis (NASH), chronic hepatitis B (HBV), and hepatitis C (HCV). Material-Methods. We studied 38 consecutive patients with biopsy-proven NASH, 19 patients with HCV, 45 patients with HBV, and 35 healthy controls who were similar for age and gender. The stage of fibrosis was measured using a 6-point scale. Results. NLR was significantly higher in NASH patients compared to controls, HBV, and HCV patients (p<0.001, p<0.001, and p<0.001, respectively). NLR was positively associated with NAFLD activity scores (r=0.861, p<0.001). NLR was associated with hepatocyte ballooning degeneration (r=0.426, p=0.024), lobular inflammation(r=0.694, p<0.001), steatosis(r=0.498, p=0.007), and fibrosis stage(r=0.892, p<0.001) in NASH patients. Univariate and multivariate analyses showed that NLR was significantly associated with liver fibrosis and NAS (beta=0.631, p<0.001 for liver fibrosis; beta=0.753, p<0.001 for NAS in the multivariate model); however, CRP had no association with liver fibrosis and NAS. Conclusion. NLR is a promising and inexpensive inflammation marker that correlates with histological grade and fibrosis stage in NASH patients.Öğe Sub-Diaphragmatic Bronchogenic Cysts: Report of Two Cases(Derman Medical Publ, 2016) Nadir, Isilay; Kasapoglu, Benan; Kafadar, Mehmet Tolga; Yildirim, Umran; Nadir, AydinAn intra-abdominal tumor originating from a bronchogenic cyst is an extremely rare entity. Although commonly located in the thoracic cavity, these cysts are occasionally present underneath and even within the diaphragm. We report two cases of bronchogenic cysts localized in the extra-thoracic region and treated with surgical therapy, in light of the current literature.
