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    Effect of underlying infertility factors on second trimester serum screening results
    (2014) Köşüş, Nermin; Koşus, Aydin; Duran, Müzeyyen; Turhan, Nilgün Öztürk
    Objective:To determine whether assisted reproductive technologies (ART) alone or an underlying cause of infertility has any effect on second trimester serum screening results. Study Design: Second trimester serum screening results of ART pregnancies of women with polycystic ovary syndrome (IVF-P group) were compared with those of women who underwent ART due to male factor infertility (IVF-M group) and of women who conceived spontaneously. Results: Comparison of the groups for ?-fetoprotein, ?-hCG, and ?-hCG multiples of the median (MoM) revealed a significant difference between the IVF-M and control groups. Comparison of groups for unconjugated estriol (uE3) and uE3 MoM levels revealed a statistically significant difference between the IVF-P versus the control groups. Conclusion: It seems advisable to use a population of ART pregnancies, preferably divided by type of treatment and the etiology of the infertility, when establishing median curves for second trimester serum screening markers. © Journal of Reproductive Medicine®, Inc. © 2014 Elsevier B.V., All rights reserved.