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Öğe Biochemical Changes in Cancer(Derman Medical Publ, 2014) Erdamar, Husamettin; Kazanci, Fatmanur Hacievliyagil; Gok, SumeyyeAfter cardiovascular diseases, the most common reasons of death in the world is cancer. However, oncologists think that Nobody dies from cancer, the patiences pass away due to the results of metabolic changes stemmed from cancer. The identification of metabolic changes which is caused by cancer opens new insights to doctors in diagnosing and therapy. For instance, the method of imaging of Positron emission tomography (PET), which is used for the cancer grading, involves the changes of glucose metabolism in cancer cells. Another case related to this subject is that the differential diagnosis between residue metastasis and edema of the suspect area in the image of postoperative control brain magnetic resonance (MR) for a patient who is operated because of brain tumor can be made via MR spectroscope device by analyizing the metabolic activity of that area regarding the level of choline, creatinine, N-Asetyl aspartene and lactate. In this review, the main changes of metabolism of protein, carbonhydrate and lipid, and membrane structure in cancer patience will be mentioned. Furthermore, paraneoplastic syndrome and the tumor lysis syndrome, an urgent oncologic case, which can be seen in the 20 percent of cancer patience, will be undertaken.Öğe Increased levels of serum granzyme-B is associated with insulin resistance and increased cardiovascular risk in adolescent polycystic ovary syndrome patients(Elsevier, 2016) Oztas, Efser; Ozler, Sibel; Tokmak, Aytekin; Yilmaz, Nafiye; Celik, Huseyin Tugrul; Kazanci, Fatmanur Hacievliyagil; Danisman, NuriObjectives: Our aim was to determine serum perforin and granzyme-B levels in adolescent PCOS patients, and to investigate whether they are associated with some of the insulin sensitivity, obesity and cardiovascular (CV) risk markers and metabolic syndrome. Study design: A case-control study was carried out including a total of 172 adolescents (83 PCOS patients and 89 age-matched healthy controls). Participants were recruited consecutively. Homeostasis model assessment (HOMA-IR), lipid parameters, and anthropometric measurements were determined. Serum perforin and granzyme B levels were measured by commercially available ELISA kits. HOMA-IR > 3.16 was considered to indicate the presence of insulin resistance. Logistic regression analysis was applied for the predictive value of granzyme-B for increased CV risk in PCOS patients. Results: As body mass index (BMI) of the PCOS patients was significantly higher than the controls (median 24.6 kg/m(2) and 21.4 kg/m(2), respectively, p < 0.001) all parameters were evaluated after adjustment for BMI. Adolescents with PCOS had significantly higher levels of fasting glucose, insulin, HOMA-IR and granzyme-B when compared with controls. According to the results of logistic regression analysis, granzyme-B levels were found to be significantly associated with increased HOMA-IR (OR = 6.120, 95% CI: 2.352-15.926, p < 0.001) in adolescent PCOS patients. Additionally, elevated levels of serum granzyme-B were predictive for increased CV risk in PCOS patients (OR = 0.237, 95% CI: 0.091-0.616, p = 0.003). Conclusions: Increased levels of serum granzyme-B are independently associated with insulin resistance and also with increased CV risk in adolescent polycystic ovary syndrome patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.Öğe Investigation of the Levels of Serum Amyloid A, YKL-40, and Pentraxin-3 in Patients with Familial Mediterranean Fever(Wiley, 2016) Ciftci, Sefa; Celik, Huseyin Tugrul; Atukeren, Pinar; Ciftci, Nurdan; Deniz, Mustafa Saygin; Yavuz, Yasemin Coskun; Kazanci, Fatmanur HacievliyagilBackgroundFamilial Mediterranean Fever (FMF) is an autosomal recessive form of recurrent episodes of fever and an autoinflammatory disease characterized by inflammation of the serous membranes. The clinical diagnosis is supported by the laboratory findings. This study investigated the relationship of Serum Amyloid A (SAA), YKL-40, and Pentraxin-3 (PTX-3) with the FMF disease. MethodsAbout 50 patients with FMF were enrolled in this study. Patients were divided into three groups according to disease severity score (mild, moderate, and severe). Thirty-seven healthy individuals were included as the control group. Serum SAA, YKL-40, and PTX-3 concentrations were measured using an ELISA kit. ResultsSerum SAA and YKL-40 levels of FMF patients were significantly higher than in the control (P < 0.001). PTX-3 levels were found to be higher in patients even though there was no significant difference (P = 0.113). Whereas the positive predictive value was 71.9% for cut-off point of SAA, the positive predictive value was 83.3% for cut-off point of YKL-40. Whereas a significant correlation was detected in SAA and PTX-3 with YKL-40 (respectively; P = 0.036, P < 0.001), there was no correlation between the PTX-3 with SAA (P = 0.219). ConclusionsYKL-40 can be used together with SAA to support the diagnosis of FMF and to monitor the severity of the disease. In this study, YKL-40 levels were examined for the first time in FMF patients and further studies are necessary using larger patient samples.Öğe Is it possible to remove heavy metals from the body by wet cupping therapy (Al-hijamah)?(Natl Inst Science Communication-Niscair, 2016) Gok, Sumeyye; Kazanci, Fatmanur Hacievliyagil; Erdamar, Husamettin; Gokgoz, Nurcan; Hartiningsih, SitiSugih; Dane, SenolWet cupping therapy (WCT) is a traditional blood-letting method recommended for treating a lot of diseases. Al-hijamah is WCT of prophetic medicine that's also called the triple S technique that includes skin suction, scarification and second suction. Its mechanism of action is still unknown but it is believed to remove toxic substances from the body according to the evidence-based Taibah mechanism (Taibah theory). In this study, the aim was to compare wet cupping blood and venous blood samples in terms of heavy metals concentrations. 24 healthy volunteers were enrolled in this study. After venous blood samples were drawn, WCT (Al-hijamah) was performed and wet cupping blood samples were taken. In order to measure the levels of heavy metals all samples were analyzed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). In the present study, all levels of selected heavy metals were significantly higher in wet cupping blood than venous blood. It may be possible to remove heavy metals from the body through wet cupping therapy.Öğe Is magnetic resonance imaging really innocent?(Walter De Gruyter Gmbh, 2014) Erdamar, Husamettin; Gurgel, Ahmet; Namuslu, Mehmet; Celik, Huseyin Tugrul; Kazanci, Fatmanur Hacievliyagil; Ogretici, Aslihan Busra; Yigitoglu, M. Ramazan[Abstract Not Available]Öğe Response to A new remedial approach to oxidant/antioxidant imbalance-based diseases: Wet-cupping therapy(Churchill Livingstone, 2015) Celik, Huseyin T.; Kazanci, Fatmanur Hacievliyagil; Ciftci, Sefa; Erdamar, Husamettin[Abstract Not Available]Öğe THE EFFECT OF DIFFERENT TURKISH SONG COMPOSITIONS ON THE SYMPATHIC AND IMMUNOBIOCHEMICAL PARAMETERS(Nobel Ilac, 2015) Yuksel, Sevda; Kazanci, Fatmanur Hacievliyagil; Ciftci, Sefa; Altan, Merve; Yuksel, Mustafa; Erdamar, Husamettin; Yigitoglu, RamazanObjective: Turkey is a rich country in musical heritage. Studies on the use of music for therapeutic purposes are increasing day by day. The Greek philosophers were convinced that music benefited health and specific recommendations were formulated for using music therapeutically against mental and physical illness. To evaluate the effects of different classical Turkish music styles (Saba, Muhayyer Kurdi, Hijaz, Ussak) on these parameters. Therefore we planned this research to accomplish all of these aims. Material and Method: Venous blood samples were collected before and after music listening and serum levels of serotonin, adrenalin, immunoglobulin A and cortisol were measured. Sixtyone healthy volunteers listened five different kinds of music (popular, rock, arabesque, European classical, classical Turkish music). Results: To compare the same parameters in each volunteer before and after music listening, the Wilcoxon signed-ranks were performed as appropriate. For tests of significance, a p-value of <0.05 was considered to be statistically significant. All parameters were normally distributed. Conclusion: Our Statistical analysis results showed that cortisol level of the people listening Saba style decreased, Immunoglobulin A level decreased for the people who listened popular music and increased for the group listening Nihavent style and adrenaline level increased significantly in all groups except for the people listening Ussak style of music.Öğe Wet-cupping removes oxidants and decreases oxidative stress(Churchill Livingstone, 2014) Tagil, Suleyman Murat; Celik, Huseyin Tugrul; Ciftci, Sefa; Kazanci, Fatmanur Hacievliyagil; Arslan, Muzeyyen; Erdamar, Nazan; Kesik, YunusObjectives: Wet-cupping therapy is one of the oldest known medical techniques. Although it is widely used in various conditions such as acute \ chronic inflammation, infectious diseases, and immune system disorders, its mechanism of action is not fully known. In this study, we investigated the oxidative status as the first step to elucidate possible mechanisms of action of wet cupping. Material and methods: Wet cupping therapy is implemented to 31 healthy volunteers. Venous blood samples and Wet cupping blood samples were taken concurrently. Serum nitricoxide, malondialdehyde levels and activity of superoxide dismutase and myeloperoxidase were measured spectrophotometrically. Results: Wet cupping blood had higher activity of myeloperoxidase, lower activity of superoxide dismutase, higher levels of malondialdehyde and nitricoxide compared to the venous blood. Conclusion: Wet cupping removes oxidants and decreases oxidative stress. (C) 2014 Elsevier Ltd. All rights reserved.
