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Öğe Attitudes towards influenza vaccination in high socioeconomic status Turkish parents(Tubitak Scientific & Technological Research Council Turkey, 2014) Gunduz, Suzan; Yuksel, Cigdem Nuket; Aktoprak, Hale Bozkurt; Canbal, Metin; Kaya, MehmetBackground/aim: To better understand the knowledge, attitudes, and demographic factors that influence the rate of influenza vaccination among high socioeconomic status parents. Materials and methods: questionnaire exploring the attitudes of parents to the influenza vaccine, and their knowledge about influenza and its vaccination, was given to parents of children from 1 through 16 years of age attending the Turgut Ozal University Hospital after the 2011/12 influenza season. Results: In the present study, 285 mothers and their children participated and 8.8% (n = 25) of children had the influenza vaccination. Between the vaccinated and nonvaccinated groups, there were statistically significantly differences for having received the recommendation of the physician, consulting with the physician, having the influenza vaccine previously, and having a chronic disease. The most common misconceptions of the parents about the vaccine were; there being no need for it, it not being useful, it having no effect, and it being harmful. Parents' knowledge about influenza and the influenza vaccine were not satisfactory. Conclusion: Reliable information from both health care providers during visits and the media about influenza, its severity, and the effectiveness and side effects of its vaccine should be provided.Öğe Changes of the Expressions of Orphan and gon-ADAMTS in Chondrosarcoma Cells(Akad Doktorlar Yayinevi, 2015) Isik, Bunyamin; Erdemli, Haci K.; Comertoglu, Ismail; Akyol, Sumeyya; Firat, Ridvan; Kaya, Mehmet; Akyol, OmerSome of A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) enzymes have been suggested to facilitate invasion and metastasis in cancer. ADAMTS20 is called gon-ADAMTS and ADAMTS10 and -17 are called orphan ADAMTSs. ADAMTS20 degrades versican and aggrecan in extracellular matrix. We aimed to investigate the effects of insulin on ADAMTS10,-17 and -20 in OUMS-27 chondrosarcoma cells. OUMS-27 cells were cultured in Dulbecco's modified Eagle' medium (DMEM) containing 10 mu g/mL insulin. The medium was changed every other day up to 11th day. Cells were harvested at 1, 3, 7, and 11th days and RNA isolation was performed at appropriate times according to study setup. The levels of RNA expression of ADAMTS10,-17 and -20 were estimated by qRT-PCR using appropriate primers. ADAMTS10 mRNA expression gradually decreased within 7 days after insulin induction compared to control group. There was a significant difference between control and Day 7 groups (p=0.021) as well as Day 1 and Day 7 groups (p=0.028). ADAMTS17 mRNA expression increased right after insulin induction at day 1 compared to control group and protected its high levels throughout insulin application. The most evident and statistically significant increase in mRNA concentration was observed at day 7 after insulin induction (p=0.014). Our results demonstrated that ADAMTS10,-17 and -20 might have a role in cancer progression. Although functions of ADAMTS10 and -17 are not known, their expression levels have changed in chondrosarcoma cell line. Further studies are needed to characterize chondrosarcoma cells because of the possible association of cancer progression and ADAMTS proteins.Öğe Olive Oil and Health: Bioactive Constituents, Antioxidant Properties and Clinical Implications(Duzce Univ, 2013) Armutcu, Ferah; Namuslu, Mehmet; Yuksel, Ramazan; Kaya, MehmetMediterranean countries have lower rates of mortality from cardiovascular disease and cancer than other European countries. Olive oil is the major source of dietary fat in the Mediterranean diet, and its regular consumption is thought to have various beneficial effects on human health. The biological features ascribed to olive oil consumption are associated in part to its phenolics constituents, and mainly linked to the direct or indirect antioxidant activity of olive oil phenolics and other components such as oleic acid and squalene. The major phenolic compounds identified and quantified in olive oil belong to three groups which all of them have potent antioxidant properties; simple phenols (hydroxytyrosol, tyrosol), secoiridoids (oleuropein) and the lignans. Among these substances the last two classes include the most concentrate phenols of virgin olive oil. As observed in traditional Mediterranean populations, it has been confirmed that extra virgin olive oil is beneficial when consumed properly. Many evidence indicates, however, that olive oil and its components contribute significantly to the health benefits of the Mediterranean diet, with more of an effect on prevention than treatment. This paper summarizes the evidence supporting the potentially beneficial effects of olive oil phenolics and other bioactive components.Öğe Relationship between internet addiction and alexithymia among university students(Canadian Soc Clinical Investigation, 2016) Baysan-Arslan, Seher; Cebeci, Sevsen; Kaya, Mehmet; Canbal, MetinPurpose: Epidemiological studies concerning internet addiction found that 50% of internet addicts also have other kinds of psychiatric disorders. This study aims to examine the relationship between alexithymia and internet addiction levels among Turgut Ozal University students in Ankara, Turkey. Method: University students (1,107 students; 452 students from 12 associate degree programs and 655 students from 10 undergraduate programs) participated in the study. The researchers used the personal information form, the Toronto Alexithymia Scale and the Internet Addiction Scale. The approval for the current study was received from the Turgut Ozal University Medical Faculty Clinical Studies Ethics Committee. Results: The number of the alexithymic students was 12.5% whereas the number of the students who were internet addicts was 13.5%. The internet addiction scores were higher among alexithymic individuals than the non-alexithymic (p < 0.001). There was a significant difference in internet addiction average scores between male and female students (p = 0.001). 'Difficulty identifying feeling' scores were higher among females whereas externally oriented thinking' scores were higher among males. Conclusion: The study findings suggest that the internet addiction scores were significantly higher among alexithymic individuals than those who are non-alexithymic. The most obvious reason for this relationship may that alexithymic individuals try to regulate their emotional moods through addictive behavior. There is a need for more comprehensive studies on this subject in the literature.Öğe Simultaneous analysis of biochemical markers in vitreous humour and serum: a preliminary study on the effect of storage time at -20°C(Taylor & Francis Ltd, 2016) Gurler, Mukaddes; Ozturk, Gulfer; Kir, M. Ziya; Ginis, Zeynep; Erden, Gonul; Akyol, Sumeyya; Kaya, MehmetVitreous humour (VH) is a quite stable and well-protected biological fluid from post-mortem degradation and contamination, making it a usable specimen in forensic pathology. We aimed to analyse the biochemical markers in VH stored for one month at -20 degrees C and to compare them with those of serum samples of the same deceased people. To the best of our knowledge this is the first time this has been reported in the literature. Serum levels of sodium, potassium and calcium, phosphorous and VH levels of calcium, creatinine, and urea were not statistically different between fresh and stored samples. There was no significant difference in VH urea and creatinine levels whereas serum levels were significantly decreased by the 15th and 30th days. In conclusion, urea and creatinine levels in VH showed adequate stability after one month of storage at -20 degrees C, whereas large variations were seen in the stability of inorganic components such as Na, K, Mg, Cl, and P. Our results indicate the validity of using post-mortem VH samples for urea and creatinine but not for VH stored at -20 degrees C for a limited time frame. The differences in sample handling before being stored at -20 degrees C may introduce bias on some components of VH.Öğe The obesity prevalence among students between the ages of 5 and 19 in Kutahya(Tubitak Scientific & Technological Research Council Turkey, 2014) Kaya, Mehmet; Sayan, Aylin; Birinci, Mustafa; Yildiz, Mevlut; Turkmen, KamilAim: To determine the prevalence of obesity among students between the ages of 5 and 19 in Kutahya, and to determine the factors associated with obesity prevalence. Materials and methods: The population in the survey was formed of students between the ages of 5 and 19 in the schools of Kutahya. Within the scope of this survey, obesity was evaluated in accordance with the percentile values indicated in a study on the body weight and height, head circumference, and body mass index reference values of Turkish children that was published in 2008. Results: It was determined that 6.5% of the students were obese, 7.8% of them were overweight, and 7.8% of them were underweight. When the variables of age, sex, and school district were controlled, it was seen that obesity prevalence among students studying at private schools was 2.03 times higher than among students studying at public schools (P < 0.001). Conclusion: It is seen that, in the efforts to reduce childhood obesity, private schools should be considered as a risk factor and the obesity prevalence at private schools should be analyzed in further studies.Öğe The role of reactive oxygen species and oxidative stress in carbon monoxide toxicity: An in-depth analysis(Maney Publishing, 2014) Akyol, Sumeyya; Erdogan, Serpil; Idiz, Nuri; Celik, Safa; Kaya, Mehmet; Ucar, Fatma; Dane, SenolThe underlying mechanism of the central nervous system (CNS) injury after acute carbon monoxide (CO) poisoning is interlaced with multiple factors including apoptosis, abnormal inflammatory responses, hypoxia, and ischemia/reperfusion-like problems. One of the current hypotheses with regard to the molecular mechanism of CO poisoning is the oxidative injury induced by reactive oxygen species, free radicals, and neuronal nitric oxide. Up to now, the relevant mechanism of this injury remains poorly understood. The weakening of antioxidant systems and the increase of lipid peroxidation in the CNS have been implicated, however. Accordingly, in this review, we will highlight the relationship between oxidative stress and CO poisoning from the perspective of forensic toxicology and molecular toxicology.
