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    Investigation of the Level of Serum Irisin in Patients With Gestational Diabetes Mellitus
    (2021-03-10) Kahraman, Gülcan; Kahraman, Mustafa; Öterkuş, Mesut
    Aim: In pregnancy, the most common metabolic disorder is Diabetes Mellitus (DM). Gestational diabetes mellitus (GDM) is glucose intolerance that first appears during pregnancy or is diagnosed. Especially in late pregnancy, the fetüs, rapidly growing glucose metabolism, directs glucose and amino acids to the fetus. The mother’s energy needs are arranged in the provision (free fatty acids, ketones, and glycerol) from alternative sources. It is the irisin the main function is turning from white adipose tissue to brown adipose tissue, uncover energy as heat and induced by exercises, such as weight loss, reduction in insulin resistance, associated with obesity, glucose regulation and effects on lipid metabolism are known to have many physiological properties. This study, it is aimed to investigate the level of irisin, which is GDM involved in energy metabolism, a new hormone. Material and Method: In Firat University Faculty of Medicine, Obstetrics and Gynecology Clinic, the 40 pregnant women diagnosed with GDM (Group 1) and 40 healthy pregnant women without any problems in pregnancy (Group 2) so that the total 80 patients were included in this study. These groups were divided into four subgroups, GDM in the second trimester, 20 patients (Group 1A), GDM in the third trimester, 20 patients (Group 1B), In the second trimester, 20 healthy patients (Group 2A), In the third trimester, 20 healthy patients (Group 2B). Results: In this study compared with control groups, serum irisin levels were increased significantly, including the 2. trimester higher (263.70±127.69 ng/ml) in the GDM group. There was no correlation between serum irisin level and BMI. Conclusion: In future studies, the necessity of questioned physical activity and exercise, the need for more extensive experimental and clinical studies, and if the pathophysiological mechanisms between the iris and GDM are illuminated, the clinical conclusion was reached irisin related options can be treated.
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    Stress And Fluid Restriction Before Anesthesia İnduction, İnvestigation Of The Effects Of The Patient’s Clinic, Endocrine Responses, And The Level Of The Nesfatin-1
    (2021-05-15) Kahraman, Mustafa; Öterkuş, Mesut; Kahraman, Gülcan
    Background/Aim: Preoperative fasting, fluid restriction and stress trigger many hormonal responses, one of which is the newly described Nefsatin-1. It has important effects on energy metabolism and stress. In this study, we aimed to examine the relationship between stress, fasting, fluid restriction, and Nesfatin-1. Methods: A total of 100 ASA I-II adult patients between 18 and 60 years of age with no psychiatric, cardiovascular, or metabolic disorders, who were operated under general anesthesia for various reasons at Fırat University Hospital between June and November 2013 were included in this randomized prospective case-control study. Patients were categorized into fluid restriction (Group 1) and no-fluid restriction (Group 2) groups. These groups were further sub-categorized as those receiving (Groups 1A and 2A) and not receiving pre-medication (Group 1B and Group 2B). State Trait Anxiety Inventory was applied to all patients by an independent member of the research team before the surgical procedure. Also, blood samples were obtained 6-8 hours, 1 hour, and just before the induction to measure insulin, glucose, epinephrine, norepinephrine, cortisol, and Nesfatin-1 levels. Results: In both groups, the test score for pre-operative anxiety was 44. While there were no differences in serum insulin levels between the study groups (P>0.05), serum glucose and epinephrine levels were higher in Group 1A than in other groups (P<0.05 for both). Except for the 2nd period, serum norepinephrine levels were elevated in all stages (P<0.05). Serum cortisol levels were higher in Group 2B (P<0.05), while serum Nesfatin-1 levels were higher in Group 2A (P<0.05). Conclusion: According to our findings, the highest reflection of stress in patients, together with clinical and endocrine responses, coincided just before the induction period. Further studies are warranted before firmer conclusions can be drawn regarding the association between Nesfatin-1 and anxiety. We believe that if the pathophysiological mechanisms between anxiety and Nesfatin-1 are clarified, Nesfatin-1 targeting treatment approaches can be tried in the clinic.