Yazar "Gulec, Mehmet Akif" seçeneğine göre listele

Listeleniyor 1 - 9 / 9
  • Küçük Resim Yok
    Öğe
    A commentary on The effectiveness of oxygen therapy in carbon monoxide poisoning is pressure- and time-dependent: A study on cultured astrocytes
    (Elsevier Ireland Ltd, 2015) Gulec, Mehmet Akif; Akyol, Omer; Akyol, Sumeyya
    [Abstract Not Available]
  • Küçük Resim Yok
    Öğe
    A new therapeutic approach for carbon monoxide poisoning: Antioxidants
    (Elsevier Ireland Ltd, 2015) Akyol, Sumeyya; Gulec, Mehmet Akif; Erdemli, Haci Kemal; Akyol, Omer
    [Abstract Not Available]
  • Küçük Resim Yok
    Öğe
    Can propolis and caffeic acid phenethyl ester be promising agents against cyclophosphamide toxicity?
    (Ejmanager Llc, 2016) Akyol, Sumeyya; Gulec, Mehmet Akif; Erdemli, Haci Kemal; Akyol, Omer
    Propolis is a mixture having hundreds of polyphenols including caffeic acid phenethyl ester (CAPE). They have been using in several medical conditions/diseases in both in vitro and in vivo experimental setup. Cyclophosphamide (CP) has been used to treat a broad of malignancies including Hodgkin's and non-Hodgkin's lymphoma, Burkitt's lymphoma, chronic lymphocytic leukemia, Ewing's sarcoma, breast cancer, testicular cancer, etc. It may cause several side effects after treatment. In this mini review, the protective effects of propolis and CAPE were compared each other in terms of effectiveness against CP-induced injuries.
  • Küçük Resim Yok
    Öğe
    Melatonin and caffeic acid phenethyl ester in the regulation of mitochondrial function and apoptosis: The basis for future medical approaches
    (Pergamon-Elsevier Science Ltd, 2016) Erdemli, Haci Kemal; Akyol, Sumeyya; Armutcu, Ferah; Gulec, Mehmet Akif; Canbal, Metin; Akyol, Omer
    The aim of this review article is to summarize and compare the effects of melatonin and caffeic acid phenethyl ester (CAPE) on the relationship between mitochondrial functioning and apoptosis. References in this article were selected with an approach based on a comprehensive literature review by using MEDLINE/PubMed and Google Scholar databaseswhichwere scanned in the last six months without any restrictions. For each database, the review terms used are 'melatonin', 'caffeic acid phenethyl ester, both together and associated with other key words such as apoptosis and mitochondria. Evidential mitochondrial molecular backgrounds for diseases make these twomolecule competitors, since both of themuse the same pathways to copewith fundamentals of the diseases such as nuclear factor kappa-light-chain-enhancer of activated B (NF-kappa B inhibition, induction of mitochondrial apoptosis in cancer cells, free radical scavenging effects, and antioxidant activities. The data reviewed in this paper provide a useful background for the understanding of some molecular details of melatonin and CAPE on several medical situation and diseases. Mutual usage of these two tremendous molecules might have a capacity to open new therapeutic approaches in near future. (C) 2016 Elsevier Inc. All rights reserved.
  • Küçük Resim Yok
    Öğe
    Pathophysiological Function of ADAMTS Enzymes on Molecular Mechanism of Alzheimer's Disease
    (Int Soc Aging & Disease, 2016) Gurses, Murat Serdar; Ural, Mustafa Numan; Gulec, Mehmet Akif; Akyol, Omer; Akyol, Sumeyya
    The extracellular matrix (ECM) is an environment that has various enzymes attended in regeneration and restoration processes which is very important to sustain physiological and biological functions of central nervous system (CNS). One of the participating enzyme systems in ECM turnover is matrix metalloproteinases. A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS) is a unique family of ECM proteases found in mammals. Components of this family may be distinguished from the ADAM (A Disintegrin and Metalloproteinase) family based on the multiple copies of thrombospondin 1-like repeats. The considerable role of the ADAMTS in the CNS continues to develop. Evidences indicate that ADAMTS play an important role in neuroplasticity as well as nervous system pathologies such as Alzheimer's disease (AD). It is hopeful and possible that ADAMTS family members may be utilized to develop therapies for CNS pathologies, ischemic injuries, neurodegenerative and neurological diseases. To understand and provide definitive data on ADAMTS to improve structural and functional recovery in CNS injury and diseases, this review aimed to enlighten the subject extensively to reach certain information on metalloproteinases and related molecules/enzymes. It will be interesting to examine how ADAMTS expression and action would affect the initiation/progression of above-mentioned clinical situations, especially AD.
  • Küçük Resim Yok
    Öğe
    Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits
    (Churchill Livingstone, 2016) Akyol, Sumeyya; Yuksel, Sevda; Pehlivan, Sultan; Erdemli, Haci Kemal; Gulec, Mehmet Akif; Adam, Bahattin; Akyol, Omer
    Carbon monoxide poisoning is one of the important emergency situations manifested by primarily acute and chronic anoxic central nervous system (CNS) injuries and other organ damages. Current descriptions and therapeutic approaches have been focused on the anoxic pathophysiology. However, this point of view incompletely explains some of the outcomes and needs to be investigated extensively. Considering this, we propose that reactive oxygen species (ROS) including especially nitric oxide (NO) are likely to be a key concept to understand the emergency related to CO poisoning and to discover new therapeutic modalities in CO toxicity. If we consider the hypothesis that ROS is involved greatly in acute and chronic toxic effects of CO on CNS and some other vital organs such as heart, it follows that the antioxidant and anti-NO therapies might give the clinicians more opportunities to prevent deep CNS injury. In support of this, we review the subject in essence and summarize clinical and experimental studies that support a key role of ROS in the explanation of pathophysiology of CO toxicity as well as new treatment modalities after CO poisoning. (C) 2016 Elsevier Ltd. All rights reserved.
  • Küçük Resim Yok
    Öğe
    Propolis as a Complex Compound May Contain Many Active Ingredients Like Caffeic Acid Phenethyl Ester (CAPE)
    (Kure Iletisim Grubu A S, 2016) Gulec, Mehmet Akif; Akyol, Omer; Akyol, Sumeyya
    [Abstract Not Available]
  • Küçük Resim Yok
    Öğe
    Regeneration and healing of bone and cartilage in type-1 and type-2 diabetes: the effects of insulin
    (Tubitak Scientific & Technological Research Council Turkey, 2016) Akyol, Sumeyya; Gulec, Mehmet Akif; Demirin, Hilmi; Akyol, Omer
    Increased fragility of long bones and delay in fracture healing in adults as well as skeletal development disorders in children are thought to be associated with endochondral ossification problems. The extracellular matrix (ECM) of cartilage is absorbed during endochondral ossification. During the recovery process from damage, chondrocytes undergo hypertrophy and increase their cell volume; on the other hand, it is also necessary to digest the ECM elements around the cells. Recent research on the proteolytic enzymes in ECM assumed to be responsible for the digestion is connected to proteinases digesting type II collagen and aggrecan. ADAMTS1, 4, and 5 are known as major aggrecanases within the matrix metalloproteinase (MMP) enzymes in human cartilage. These are regarded as main determiners among MMPs of bone growth, healing, and remodeling. In this mini review article, the remodeling and restoration of osseous tissue in type-1 and -2 diabetes mellitus (DM) and the effect of insulin on these processes are discussed briefly in the light of the current literature.
  • Küçük Resim Yok
    Öğe
    The Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study
    (Oxford Univ Press, 2016) Pehlivan, Sultan; Gurses, Murat Serdar; Ural, Mustafa Numan; Akyol, Sumeyya; Eren, Filiz; Inanir, Nursel Turkmen; Gulec, Mehmet Akif
    Objective: To determine the role of a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) and fragmented versican in the myocardial infarction (MI) process in humans and to evaluate the diagnostic efficacy of ADAMTS1 for postmortem diagnosis of MI. Methods: Thirty autopsied individuals were allocated into 2 groups, namely, a study group of individuals who died of myocardial infarction (n = 20), and a control group who died of trauma (n = 10). We performed standard immunohistochemical staining on myocardial tissue specimens, studying anti-ADAMTS1, anti-versican, and anti-versican C terminal peptide sequence (DPEAAE) fragments. Results: Strong, diffuse staining was observed throughout myocardial tissue for ADAMTS1 in the 2 groups. However, in the study group, we observed no expression for ADAMTS1 around fibrotic areas but detected slight staining in coagulative and necrotic zones. Conclusion: Similar localizations of ADAMTS and fragmented versican in human heart tissue indicate that versican presumably is cleaved by ADAMTS1. Hence, ADAMTS1 can be regarded as a new marker for postmortem differential diagnosis of MI.