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    Biochemical Changes in Cancer
    (Derman Medical Publ, 2014) Erdamar, Husamettin; Kazanci, Fatmanur Hacievliyagil; Gok, Sumeyye
    After cardiovascular diseases, the most common reasons of death in the world is cancer. However, oncologists think that Nobody dies from cancer, the patiences pass away due to the results of metabolic changes stemmed from cancer. The identification of metabolic changes which is caused by cancer opens new insights to doctors in diagnosing and therapy. For instance, the method of imaging of Positron emission tomography (PET), which is used for the cancer grading, involves the changes of glucose metabolism in cancer cells. Another case related to this subject is that the differential diagnosis between residue metastasis and edema of the suspect area in the image of postoperative control brain magnetic resonance (MR) for a patient who is operated because of brain tumor can be made via MR spectroscope device by analyizing the metabolic activity of that area regarding the level of choline, creatinine, N-Asetyl aspartene and lactate. In this review, the main changes of metabolism of protein, carbonhydrate and lipid, and membrane structure in cancer patience will be mentioned. Furthermore, paraneoplastic syndrome and the tumor lysis syndrome, an urgent oncologic case, which can be seen in the 20 percent of cancer patience, will be undertaken.
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    Evaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia
    (Taylor & Francis Ltd, 2016) Gokdemir, Irem Eda; Ozdegirmenci, Ozlem; Elmas, Burak; Sarikaya, Esma; Tokmak, Aytekin; Kazanci, Fatmanur H.; Gok, Sumeyye
    Objective: Pre-eclampsia is the result of impaired trophoblast invasion and spiral artery remodeling managed by inflammatory response in its etiology and physiopathology. The aim of this study was to compare serum molecules including IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels between pre-eclampsia and control groups and to investigate the role of these molecules in pre-eclampsia.Methods: Forty-one women diagnosed as pre-eclampsia between 30 and 40 weeks of gestation and 41 non-complicated pregnant women were enrolled in this cross-sectional, case-control prospective study. ELISA method was used to determine IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels within serums in two groups.Results: Serum ADAMTS12 and IL-33 levels were significantly lower in pre-eclampsia group (p<0.001 and p: 0.028, respectively), however, in sub-group analysis, no significant difference was observed (p>0.05). The cut-off value of ADAMTS12 levels to discriminate pre-eclampsia with %73.17 sensitivity and %92.68 specificity was 8.27ng/ml while the cut-off value for IL-33 was 0.23pg/ml with 82.93% sensitivity and 53.66% specificity.Conclusion: Pre-eclampsia is associated with lower serum IL-33 and ADAMTS12 levels.
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    Is it possible to remove heavy metals from the body by wet cupping therapy (Al-hijamah)?
    (Natl Inst Science Communication-Niscair, 2016) Gok, Sumeyye; Kazanci, Fatmanur Hacievliyagil; Erdamar, Husamettin; Gokgoz, Nurcan; Hartiningsih, SitiSugih; Dane, Senol
    Wet cupping therapy (WCT) is a traditional blood-letting method recommended for treating a lot of diseases. Al-hijamah is WCT of prophetic medicine that's also called the triple S technique that includes skin suction, scarification and second suction. Its mechanism of action is still unknown but it is believed to remove toxic substances from the body according to the evidence-based Taibah mechanism (Taibah theory). In this study, the aim was to compare wet cupping blood and venous blood samples in terms of heavy metals concentrations. 24 healthy volunteers were enrolled in this study. After venous blood samples were drawn, WCT (Al-hijamah) was performed and wet cupping blood samples were taken. In order to measure the levels of heavy metals all samples were analyzed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). In the present study, all levels of selected heavy metals were significantly higher in wet cupping blood than venous blood. It may be possible to remove heavy metals from the body through wet cupping therapy.
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    The Effects of Valsartan and Amlodipine on the Levels of Irisin, Adropin, and Perilipin
    (Clin Lab Publ, 2015) Celik, Huseyin Tugrul; Akkaya, Nermin; Erdamar, Husamettin; Gok, Sumeyye; Kazanci, Fatmanur; Demircelik, Bora; Cakmak, Muzaffer
    Background: Hypertension and obesity are two major threats for public health. Up to the present, antihypertensive medications have been used to lower blood pressure, which seem to provide a better life with lower morbidity and mortality rates. Their effect on etiopathogenesis of hypertension is now an area of developing research. The association between hypertension and obesity also suggests the link between antihypertensive agents and energy hemostasis. We aimed to investigate the effects of antihypertensive treatment on the irisin, adropin, and perilipin levels in patients with essential hypertension and to compare them with healthy volunteers in terms of their effect on energy hemostasis. Methods: In total, 85 newly diagnosed patients with untreated essential hypertension were admitted to the outpatient clinic. Patients were randomized to one of the following treatment protocols: amlodipine or valsartan for a 12 week period. 42 patients were randomized into the valsartan group and 43 patients into the amlodipine group. Serum perilipin, irisin, and adropin levels were measured before and after drug treatment by ELISA kits. Results: We discovered that the hypertensive patients have lower levels of perilipin and higher levels of adropin compared with the control group. Both amlodipine and valsartan increased the levels of perilipin, irisin, and adropin after 12 weeks of treatment. Conclusions: In conclusion, in regulating energy balance, perilipin, irisin, and adropin, could be of pathogenic importance in obesity-induced hypertension. Hence, ongoing trials need to elucidate this mechanism.
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    The Role of Asymmetric Dimethyl Arginine and Nitric Oxide in Patients with Chronic Pancreatitis
    (Canadian Soc Clinical Investigation, 2015) Cakmak, Muzaffer; Erdamar, Husamettin; Kazanci, Fatmanur; Gok, Sumeyye; Abusoglu, Sedat; Unlu, Ali; Aydin, Safak
    Purpose: Endothelial dysfunction (ED) is a well-known pathological feature in the development of many diseases. The dysfunctional condition includes reduction in nitric oxide (NO) bioavailability. Chronic pancreatitis (CP) is a progressive and irreversible destruction of pancreas, and may lead to varying degrees of endocrine and exocrine dysfunction. NO released from endothelial cells is thought to be involved in the pathogenesis of CP; however, there is no study investigating the relationship between CP and ED. The purpose of this study was to investigate the levels of NO and methylarginines, including AMDMA, in patients with CP. Patients and Methods: A total of 44 patients with CP and 36 healthy volunteers were included in this study. Serum levels of ADMA, SDMA, NMMA, arginine, and citrulline were analyzed by LC-MS/MS and nitric oxide levels were analyzed using ELISA. Results: Serum SDMA levels were higher in patients with CP (0.55 +/- 0.02 mu mol/L vs. 0.47 +/- 0.02 mu mol/L, p=0.041), whereas NMMA levels were lower in patients with CP (0.052 +/- 0.003 mu mol/L vs 0.068 +/- 0.003 mu mol/L, p<0.001). There was a correlation between the C-reactive protein and SDMA levels (r=0.443, p=0.004). Conclusion: Elevated SDMA and reduced NMMA levels may be responsible for the increased pancreatic damage. Circulating SDMA may be a better marker of stage pancreatic detriment with respect to ADMA or NO in subjects with CP. Further research for possible associations among serum SDMA, ADMA, NO and other measures of pancreatitis may be beneficial in order to better understand the pathophysiology of CP and establish more effective treatment options.