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Öğe A new therapeutic approach for carbon monoxide poisoning: Antioxidants(Elsevier Ireland Ltd, 2015) Akyol, Sumeyya; Gulec, Mehmet Akif; Erdemli, Haci Kemal; Akyol, Omer[Abstract Not Available]Öğe Antiviral properties of caffeic acid phenethyl ester and its potential application(Scopemed, 2015) Erdemli, Haci Kemal; Akyol, Sumeyya; Armutcu, Ferah; Akyol, OmerCaffeic acid phenethyl ester (CAPE) is found in a variety of plants and well-known the active ingredient of the honeybee propolis. CAPE showed anti-inflammatory, anticarcinogenic, antimitogenic, antiviral, and immunomodulatory properties in several studies. The beneficial effects of CAPE on different health issues attracted scientists to make more studies on CAPE. Specifically, the anti-viral effects of CAPE and its molecular mechanisms may reveal the important properties of virus-induced diseases. CAPE and its targets may have important roles to design new therapeutics and understand the molecular mechanisms of virus-related diseases. In this mini-review, we summarize the antiviral effects of CAPE under the light of medical and chemical literature.Öğe Can propolis and caffeic acid phenethyl ester be promising agents against cyclophosphamide toxicity?(Ejmanager Llc, 2016) Akyol, Sumeyya; Gulec, Mehmet Akif; Erdemli, Haci Kemal; Akyol, OmerPropolis is a mixture having hundreds of polyphenols including caffeic acid phenethyl ester (CAPE). They have been using in several medical conditions/diseases in both in vitro and in vivo experimental setup. Cyclophosphamide (CP) has been used to treat a broad of malignancies including Hodgkin's and non-Hodgkin's lymphoma, Burkitt's lymphoma, chronic lymphocytic leukemia, Ewing's sarcoma, breast cancer, testicular cancer, etc. It may cause several side effects after treatment. In this mini review, the protective effects of propolis and CAPE were compared each other in terms of effectiveness against CP-induced injuries.Öğe Comment on 'Caffeic acid phenethyl ester lessens disease symptoms in an experimental autoimmune uveoretinitis mouse model' by Choi JH et al. [Exp. Eye Res. 134 (2015) 53-62](Academic Press Ltd- Elsevier Science Ltd, 2015) Erdemli, Haci Kemal; Akyol, Sumeyya; Armutcu, Ferah; Akyol, Omer[Abstract Not Available]Öğe Correlation between iron stores and QTc dispersion in chronic ambulatory peritoneal dialysis patients(Informa Healthcare, 2014) Bavbek, Nuket; Yilmaz, Hakki; Erdemli, Haci Kemal; Selcuki, Yusuf; Duranay, Murat; Akcay, AliAim: We aimed to investigate the QT dispersion and corrected QT (QTc) dispersion which are suggested as the signals of ventricular arrhythmias, in patients on maintenance CAPD and to evaluate the correlation between iron stores and these electrocardiographic parameters. Materials and method: Fifty-eight patients on maintenance CAPD and 19 healthy age- and sex-matched adults without cardiac disease were included. The PD patients were divided into two groups according to whether their computerized measurements of QTc dispersion were longer than 65 ms. Results: Although QT interval was statistically significantly shorter in control group (34 +/- 28 vs. 43 +/- 34 ms; p<0.05), there was no significant difference in regards to the QTc, QT dispersion and QTc dispersion between two groups. PD patients with QTc dispersion longer than 65 ms had higher levels of serum ferritin (p = 0.038) and transferrin saturation (TSAT; p = 0.022) than the others. QTc dispersion were positively correlated with ferritin (r = 0.469, p<0.01) and TSAT (r = 0.430, p<0.01) in CAPD patients. Conclusion: Although prolonged QTc, QT dispersion and QTc dispersion were suggested as the markers of ventricular arrhythmias we did not find any significant difference in regards to these parameters between control patients and CAPD patients. But the high body iron stores in these patients increase the risk of increased QT dispersion. The concern over iron overload in dialysis patients is not only because of its oxidative toxicity, but also its precipitation of arrhythmias, which may be measured by the surrogate marker of QTc dispersion.Öğe In vitro and in vivo neuroprotective effect of caffeic acid phenethyl ester(Scopemed, 2015) Akyol, Sumeyya; Erdemli, Haci Kemal; Armutcu, Ferah; Akyol, Omer[Abstract Not Available]Öğe Is Serum Caveolin-1 a Useful Biomarker for Progression in Patients with Colorectal Cancer?(Clin Lab Publ, 2016) Erdemli, Haci Kemal; Kocabas, Ramazan; Salis, Osman; Sen, Fatma; Akyol, Sumeyya; Eskin, Fatih; Akyol, OmerBackground: Colorectal cancer (CRC) is the third most common cause of cancer diagnosed in males and the second in females. Survival is strongly related to stage at diagnosis. There is an urgent need to find a noninvasive biomarker that can be commonly applied for screening diagnosis, early detection of recurrence, and monitoring of metastatic CRC. Protein caveolin-1 (CAV-1) has been known to be expressed abnormally in colon cancer and appears to contribute to aberrant signaling and protein trafficking. There are controversial results regarding the role of CAV-1 in cancer. We hypothesized that levels of CAV-1 in serum of patients with CRC might be important to estimate the progression of the disease. Therefore, the purpose of this study is to investigate whether serum CAV-1 might be used as a factor determining progression of CRC. Methods: A total of 61 patients with CRC (26 male, 35 female) and 46 controls (38 male, 8 female) were enrolled. Serum CAV-1 levels were measured by ELISA. The relationship between CAV-1 and progression-free survival (PFS) was analyzed with use of receiver operating characteristic (ROC) and Kaplan-Meier analysis. Results were given as median (95% CI). Mann-Whitney test was used for the comparison of groups. Results: CAV-1 levels were found to be 11.5 ng/mL (10.4 - 12.9) in CRC and 11.9 ng/mL (10.7 - 14.4) in controls (p = 0.465). The serum CAV-1 levels in CRC patients with disease progression and without progression were respectively 10.0 ng/mL (8.5 - 11.3) and 12.2 ng/mL (11.1 - 14.8) (p = 0.023). In ROC analysis, if CAV-1 levels are equal or lesser than 10.73 ng/mL, it might show presence of progression with a sensitivity 73.3% and specificity 66.7% in patients with CRC (area under the ROC curve (AUC) = 0.697, p = 0.005). The mean PFS time was found to be 29.7 months (19.8 - 39.7, 95% CI for the mean) in patients who have CAV-1 level <= 10.73 ng/mL and 61.9 months (44.2 - 79.6) in patients who have CAV-1 level > 10.73 ng/mL [hazard ratios (HR) with 95% CI = 3.49 (1.26 - 9.68) (p = 0.017)]. Conclusions: Our results strongly suggest that CAV-1 levels might be used as a marker to determine progression of CRC. When considered in combination with other biomarkers of CRC, CAV-1 is clinically informative and instructive.Öğe Melatonin and caffeic acid phenethyl ester in the regulation of mitochondrial function and apoptosis: The basis for future medical approaches(Pergamon-Elsevier Science Ltd, 2016) Erdemli, Haci Kemal; Akyol, Sumeyya; Armutcu, Ferah; Gulec, Mehmet Akif; Canbal, Metin; Akyol, OmerThe aim of this review article is to summarize and compare the effects of melatonin and caffeic acid phenethyl ester (CAPE) on the relationship between mitochondrial functioning and apoptosis. References in this article were selected with an approach based on a comprehensive literature review by using MEDLINE/PubMed and Google Scholar databaseswhichwere scanned in the last six months without any restrictions. For each database, the review terms used are 'melatonin', 'caffeic acid phenethyl ester, both together and associated with other key words such as apoptosis and mitochondria. Evidential mitochondrial molecular backgrounds for diseases make these twomolecule competitors, since both of themuse the same pathways to copewith fundamentals of the diseases such as nuclear factor kappa-light-chain-enhancer of activated B (NF-kappa B inhibition, induction of mitochondrial apoptosis in cancer cells, free radical scavenging effects, and antioxidant activities. The data reviewed in this paper provide a useful background for the understanding of some molecular details of melatonin and CAPE on several medical situation and diseases. Mutual usage of these two tremendous molecules might have a capacity to open new therapeutic approaches in near future. (C) 2016 Elsevier Inc. All rights reserved.Öğe Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits(Churchill Livingstone, 2016) Akyol, Sumeyya; Yuksel, Sevda; Pehlivan, Sultan; Erdemli, Haci Kemal; Gulec, Mehmet Akif; Adam, Bahattin; Akyol, OmerCarbon monoxide poisoning is one of the important emergency situations manifested by primarily acute and chronic anoxic central nervous system (CNS) injuries and other organ damages. Current descriptions and therapeutic approaches have been focused on the anoxic pathophysiology. However, this point of view incompletely explains some of the outcomes and needs to be investigated extensively. Considering this, we propose that reactive oxygen species (ROS) including especially nitric oxide (NO) are likely to be a key concept to understand the emergency related to CO poisoning and to discover new therapeutic modalities in CO toxicity. If we consider the hypothesis that ROS is involved greatly in acute and chronic toxic effects of CO on CNS and some other vital organs such as heart, it follows that the antioxidant and anti-NO therapies might give the clinicians more opportunities to prevent deep CNS injury. In support of this, we review the subject in essence and summarize clinical and experimental studies that support a key role of ROS in the explanation of pathophysiology of CO toxicity as well as new treatment modalities after CO poisoning. (C) 2016 Elsevier Ltd. All rights reserved.Öğe The comparison of caffeic acid and caffeic acid phenethyl ester against cisplatin-induced hair cell damage(Elsevier Ireland Ltd, 2016) Akyol, Sumeyya; Erdemli, Haci Kemal; Armutcu, Ferah; Akyol, Omer[Abstract Not Available]Öğe The Investigation of ADAMTS16 in Insulin-Induced Human Chondrosarcoma Cells(Mary Ann Liebert, Inc, 2015) Cakmak, Ozlem; Comertoglu, Ismail; Firat, Ridvan; Erdemli, Haci Kemal; Kursunlu, S. Fatih; Akyol, Sumeyya; Ugurcu, VeliObjectives: A disintegrin-like metalloproteinase with thrombospondin motifs (ADAMTS) is a group of proteins that have enzymatic activity secreted by cells to the outside extracellular matrix. Insulin induces proteoglycan biosynthesis in chondrosarcoma chondrocytes. The purpose of the present in vitro study is to assess the time course effects of insulin on ADAMTS16 expression in OUMS-27 (human chondrosarcoma) cell line to examine whether insulin regulates ADAMTS16 expression as well as proteoglycan biosynthesis with multifaceted properties or not. Methods: Chondrosarcoma cells were cultured in Dulbecco's modified Eagle's medium having either 10g/mL insulin or not. While the experiment was going on, the medium containing insulin had been changed every other day. Cells were harvested at 1st, 3rd, 7th, and 11th days; subsequently, RNA and proteins were isolated in every experimental group according to their time interval. RNA expression of ADAMTS was estimated by quantitative real-time polymerase chain reaction (qRT-PCR) by using primers. Immunoreactive protein levels were encountered by the western blot protein detection technique by using proper anti-ADAMTS16 antibodies. Results: ADAMTS16 mRNA expression level of chondrosarcoma cells was found to be insignificantly decreased in chondrosarcoma cells induced by insulin detected by the qRT-PCR instrument. On the other hand, there was a gradual decrease in immune-reactant ADAMTS16 protein amount by the time course in insulin-treated cell groups when compared with control cells. Conclusion: It has been suggested that insulin might possibly regulate ADAMTS16 levels/activities in OUMS-27 chondrosarcoma cells taking a role in extracellular matrix turnover.Öğe The possible preventive effect of caffeic acid phenethyl ester (CAPE) against myringosclerosis(Springer, 2016) Erdemli, Haci Kemal; Akyol, Sumeyya; Armutcu, Ferah; Akyol, Omer[Abstract Not Available]
