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Öğe Are progranulin levels associated with polycystic ovary syndrome and its possible metabolic effects in adolescents and young women?(Springer Heidelberg, 2016) Ersoy, Ali Ozgur; Tokmak, Aytekin; Ozler, Sibel; Oztas, Efser; Ersoy, Ebru; Celik, Huseyin Tugrul; Erdamar, HusamettinPolycystic ovary syndrome (PCOS) is an important disease that may alter metabolic balances of the whole body. Progranulin is a growth factor which is related to epithelial, neuronal growth and oogenesis. Here, we aimed to investigate the diagnostic value of the levels of Progranulin in the clinical setting of PCOS, and its metabolic effects. Forty-one adolescents and young women with PCOS and 39 age and body mass index matched adolescents and young women as a control group who attended to the youth center of a tertiary referral center were included in this cross-sectional case-control study. Progranulin levels, indices of insulin sensitivity, lipidemic markers, metabolic syndrome (MetS) criteria were compared between the groups. Progranulin levels in patients with PCOS (7.48 +/- A 1.93 ng/mL) were significantly higher than in the control group (6.25 +/- A 1.98 ng/mL) (p = 0.006). Luteinizing hormone (LH) levels, LH/Follicle stimulating hormone (FSH) ratios, free testosterone, dehydroepiandrosterone sulfate (DHEAS), C-reactive protein (CRP) levels in patients with PCOS were significantly higher than in the control group (p < 0.05, for all). The MetS was present in 8 (19.5 %) of the patients in the study group and in 1 (2.3 %) of the patients in the control group (p = 0.029). There was significant inverse correlation between high-density lipoprotein cholesterol (HDL-C) and progranulin levels of patients diagnosed with PCOS (p = 0.008). Progranulin may be a novel biomarker for cardiovascular risk in patients with PCOS, thus these cases should be directed to close follow-up for possible cardiovascular diseases. Future larger studies should focus on this entity.Öğe Association between maternal ghrelin levels and hyperemesis gravidarum(Tubitak Scientific & Technological Research Council Turkey, 2013) Kaygusuz, Ikbal; Gumus, Ilknur Inegol; Yildirim, Melahat; Erdamar, Husamettin; Uysal, Aysel; Simavli, Serap Aynur; Ayyildiz, AbdullahAim: To investigate serum levels of ghrelin in pregnant women as a potential early marker for hyperemesis gravidarum (HG). Materials and methods: A cross-sectional study was carried out at Fatih University Hospital. Included in the study were 35 women with HG and 31 pregnant women without HG as a control group. The groups were compared in terms of age, gravidity, body mass index (BMI), and fasting serum thyroid-stimulating hormone (TSH) and ghrelin levels. Results: Ghrelin levels of the patients with HG were found to be significantly lower than those in the control group (P = 0.03). No intergroup differences could be found in serum TSH or BMI values. Conclusion: Ghrelin might serve as a reliable marker in the etiopathogenesis of HG.Öğe Biochemical Changes in Cancer(Derman Medical Publ, 2014) Erdamar, Husamettin; Kazanci, Fatmanur Hacievliyagil; Gok, SumeyyeAfter cardiovascular diseases, the most common reasons of death in the world is cancer. However, oncologists think that Nobody dies from cancer, the patiences pass away due to the results of metabolic changes stemmed from cancer. The identification of metabolic changes which is caused by cancer opens new insights to doctors in diagnosing and therapy. For instance, the method of imaging of Positron emission tomography (PET), which is used for the cancer grading, involves the changes of glucose metabolism in cancer cells. Another case related to this subject is that the differential diagnosis between residue metastasis and edema of the suspect area in the image of postoperative control brain magnetic resonance (MR) for a patient who is operated because of brain tumor can be made via MR spectroscope device by analyizing the metabolic activity of that area regarding the level of choline, creatinine, N-Asetyl aspartene and lactate. In this review, the main changes of metabolism of protein, carbonhydrate and lipid, and membrane structure in cancer patience will be mentioned. Furthermore, paraneoplastic syndrome and the tumor lysis syndrome, an urgent oncologic case, which can be seen in the 20 percent of cancer patience, will be undertaken.Öğe Boric acid inhibits cell proliferation through RB1 protein in head and neck cancer(Amer Assoc Cancer Research, 2015) Gunduz, Esra; Hatipoglu, Omer Faruk; Cigdem, Sadik; Erdogan, Kubra; Elitok, Mustafa Semih; Grenman, Reidar; Erdamar, Husamettin[Abstract Not Available]Öğe Effect of One Unit Blood Donation on Appetite-Related Biomarkers(Canadian Soc Clinical Investigation, 2016) Erdamar, Husamettin; Cakmak, MuzafferPurpose: It is commonly reported that blood donation (BD) leads to an increase in appetite. To investigate this claim, a questionnaire was offered to 306 people who had a history of BD at least once in their life. Following a positive outcome from the questionnaire, we further investigated the impact of BD on appetite. Materials and Methods: The questionnaire study consists of a 5-question survey with VAS was performed on 399 volunteers. Later, 108 volunteers were enrolled in a laboratory study. Blood samples were withdrawn before and after BD. Leptin, ghrelin, neuropeptide-Y (NPY), and alpha-melanocyte stimulating hormone (alpha-MSH) levels were measured by ELISA kits. VAS assessment was also performed on all participants before and after BD. Results: There was a significant decrease in the level of leptin but the levels of ghrelin, NPY and a- MSH were unchanged. A significant change in VAS value in terms of appetite was also observed. Conclusion: The elevation of appetite after BD is predominantly psychological. Hormonal changes may contribute to the control of hypothalamic hunger and satiety centers.Öğe Effects of quercetin on methotrexate-induced nephrotoxicity in rats(Sage Publications Ltd, 2017) Yuksel, Yasemin; Yuksel, Ramazan; Yagmurca, Murat; Haltas, Hacer; Erdamar, Husamettin; Toktas, Muhsin; Ozcan, OsmanObjective: This experimental study was conducted to elucidate the possible protective/therapeutic effects of quercetin against methotrexate (Mtx)-induced kidney toxicity with biochemical and histopathological studies. Methods: Twenty-four adult male rats were randomly divided into four groups, as follows: control group (saline intraperitoneally (i.p.), 9 days), Mtx group (20 mg/kg i.p., single dose), Mtx + quercetin group (50 mg/kg quercetin was orally administered 2 days before and 6 days after Mtx administration) and only quercetin group (50 mg/kg oral, 9 days). Structural changes were evaluated by hematoxylin-eosin and periodic acid-Schiff stainings. Apoptotic changes were investigated by terminal deoxynucleotidyl transferase dUTP nick end labeling assay and caspase-3 antibody. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were measured in tissue and plasma samples. Results: Mtx compared with the control group, there was significant increase in nephrotoxic tissue damage findings, in addition to apoptotic index (APOI) and caspase-3 expression (p < 0.05). Mtx + quercetin group revealed significantly lower histopathological damage and APOI and caspase-3 expression decreased when compared to Mtx group. MDA levels were increased in Mtx group compared to others, and by the use of quercetin, this increase was significantly reduced. SOD levels were higher in Mtx group than others. This increase was evaluated as a relative increase arising from oxidative damage caused by Mtx. Conclusion: As a result, Mtx administration may involve oxidative stress by causing structural and functional damage in kidney tissue in rats. Quercetin reduced the Mtx-induced oxidative stress through its antioxidant properties and so quercetin may be promising to alleviate Mtx-induced renal toxicity.Öğe Evaluation of the effects of esmolol and remifentanil for controlled hypotension application on hemodynamics and oxidative stress parameters(Anaesthesia Pain & Intensive Care, 2020) Kasikara, Hulya; Demircioglu, Ruveyda Irem; Gozdemir, Muhammet; Karabayirli, Safinaz; Erdamar, Husamettin; Namuslu, Mehmet; Yazici, UmmugulsumIntroduction: Anesthesia induced during a surgical intervention, the duration of the surgical intervention, and the surgical intervention itself tend to affect immune functions, resulting in the formation of free radicals in the metabolism. Free radicals can cause postoperative disorders by targeting biomolecules in the cell, such as lipids, carbohydrates, proteins, and DNA. In the present study, we used remifentanil or esmolol to induce a controlled hypotension in patients who were undergoing septorhinoplasty under general anesthesia, and we planned to compare the effect of these agents on hemodynamics and oxidative stress relative to the control group. Methodology: A total of 75 patients aged between 18 and 65 y, ASA I-II, planned to undergo elective septorhinoplasty, were included in this study. Patients were randomly divided into the following three groups: Group R (remifentanil group, n = 25); Group E (esmolol group, n = 25); and Group C (control, n = 25). Anesthesia was induced with 2 mg/kg propofol 2 mg/kg, fentanyl 1 mu g/kg, and rocuronium 0.6 mg/kg. Immediately after induction, Group R was started loading dose of remifentanil 1 mu g/kg/min, followed by infusion at 0.25-0.50 mu g/kg/min. In Group E, a loading dose of esmolol 500 mu g/kg was given for 1 min, then infusion was continued @ 150-300 mu g/kg. A targeted mean arterial pressure (MAP) of 55-65 mmHg was aimed. In Group C, remifentanil was infused at 0.1-0.2 mu g/kg/min until a MAP of 70-100 mmHg was reached. During operation; systolic (SAP), diastolic (DAP) and mean arterial pressure (MAP), heart rate (HR), peripheral oxygen saturation (SpO(2)), EtCO2 (end tidal CO2) were recorded before induction, after induction, after intubation, at 5-min intervals during the first 30 min, and then at 10-min intervals during the intervention. The amounts of remifentanil and esmolol consumed by the patients during the operation were calculated and recorded. Blood samples that were taken twice, preoperatively and postoperatively, for malondialdehyde (MDA), superoxide dismutase (SOD), total oxidant level (TOL), total antioxidant level (TAL), and oxidative stress index (OSI). Results: MAP showed a greater decrease starting from the 25th min and 40th min after intubation in remifentanil group and esmolol group respectively, compared to the control group. In the remifentanil and control groups, there was a statistically significant decrease in the postoperative OSI levels compared to the preoperative levels. One the other hand, in the esmolol group, there was no statistically significant difference between the preoperative and postoperative median OSI levels. There was a significant increase in the postoperative TAL of the remifentanil group compared to the preoperative level. Conclusion: It was observed that during a hypotensive anesthesia induced by remifentanil or esmolol, remifentanil ensured more stable operating conditions in terms of hemodynamics compared with esmolol, and that remifentanil was also superior to esmolol in reducing oxidative stress.Öğe Is it possible to remove heavy metals from the body by wet cupping therapy (Al-hijamah)?(Natl Inst Science Communication-Niscair, 2016) Gok, Sumeyye; Kazanci, Fatmanur Hacievliyagil; Erdamar, Husamettin; Gokgoz, Nurcan; Hartiningsih, SitiSugih; Dane, SenolWet cupping therapy (WCT) is a traditional blood-letting method recommended for treating a lot of diseases. Al-hijamah is WCT of prophetic medicine that's also called the triple S technique that includes skin suction, scarification and second suction. Its mechanism of action is still unknown but it is believed to remove toxic substances from the body according to the evidence-based Taibah mechanism (Taibah theory). In this study, the aim was to compare wet cupping blood and venous blood samples in terms of heavy metals concentrations. 24 healthy volunteers were enrolled in this study. After venous blood samples were drawn, WCT (Al-hijamah) was performed and wet cupping blood samples were taken. In order to measure the levels of heavy metals all samples were analyzed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). In the present study, all levels of selected heavy metals were significantly higher in wet cupping blood than venous blood. It may be possible to remove heavy metals from the body through wet cupping therapy.Öğe Is magnetic resonance imaging really innocent?(Walter De Gruyter Gmbh, 2014) Erdamar, Husamettin; Gurgel, Ahmet; Namuslu, Mehmet; Celik, Huseyin Tugrul; Kazanci, Fatmanur Hacievliyagil; Ogretici, Aslihan Busra; Yigitoglu, M. Ramazan[Abstract Not Available]Öğe Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients(Elsevier Taiwan, 2016) Eser, Ayla; Gumus, Ilknur Inegol; Erdamar, Husamettin; Kaygusuz, Ikbal; Yildirim, Melahat; Usluogullari, Betul; Erdolu, Muzeyyen DuranObjective: The aim of this study was to investigate factors associated with thrombosis that may contribute to recurrent pregnancy loss (habitual abortion), specifically differences in serum levels of platelet-activating factor and thrombin-activatable fibrinolysis inhibitor (carboxypeptidase B2) between women with a history of recurrent miscarriage and those with no recurrent miscarriage history. Materials and methods: A case-controlled, prospective study design was adopted to compare women with a history of two or more first-trimester miscarriages (n = 42) with those with no history of recurrent miscarriage (n = 36). Participants were recruited from the Department of Obstetrics and Gynecology of Turgut Ozal University Hospital. Platelet-activating factor and thrombin-activatable fibrinolysis inhibitor levels in serum samples were measured by an enzyme-linked immunosorbent assay. Results: Platelet-activating factor levels were significantly (p = 0.018) higher in the recurrent miscarriage group. There was no difference in levels of thrombin-activatable fibrinolysis inhibitor expression between the groups. Conclusion: Platelet-activating factor is significantly higher in serum of patients with a history of recurrent miscarriage than in those without such a history, with potential implications for placental function and fetal growth, which could be relevant to miscarriage recurrence. Larger studies are indicated to further examine these findings. Copyright (C) 2016, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC.Öğe Response to A new remedial approach to oxidant/antioxidant imbalance-based diseases: Wet-cupping therapy(Churchill Livingstone, 2015) Celik, Huseyin T.; Kazanci, Fatmanur Hacievliyagil; Ciftci, Sefa; Erdamar, Husamettin[Abstract Not Available]Öğe Serum adropin as a predictive biomarker of erectile dysfunction in coronary artery disease patients(Polish Urological Assoc, 2019) Celik, Husetin Tugrul; Bilen, Mehmet; Kazanci, Fatmanur; Yildirim, Mehmet Erol; Incebay, Ilkay Bekir; Erdamar, HusamettinIntroduction Erectile dysfunction (ED) is associated with various comorbidities and an early diagnosis and treatment is necessary to avoid the development of these comorbidities. Unfortunately, there is no biochemical marker that can be used for early diagnosis of ED. Nitric oxide (NO) is released by nerve and endothelial cells in the corpora cavernosa of the penis and is believed to be the main vasoactive chemical mediator of penile erection. Adropin is a regulatory peptide which has effects on NO bioavailability and energy homeostasis. We hypothesized that adropin may contribute to the pathogenesis of ED because of the presence of both metabolic effects and the influence on NO bioavailability. To confirm this hypothesis, we investigated the relationship between ED and serum adropin and NO levels. Materials and Methods: Seventy-five ED patients were enrolled for this study and the patients were divided into two groups according to angiographic scoring. Serum NO and adropin levels were measured by the Griess reaction and ELISA method, respectively. Results: Serum adropin and NO levels were found to be lower in the group which has higher angiographic score and the difference in NO was statistically significant. Also, adropin has a significant correlation between IIEF scores in ED patients. Conclusion: This is the first study in the literature investigating the levels of adropin in ED patients having coronary artery disease. The adropin molecule shows a promising future in clarifying the etiopathogenesis of ED. More comprehensive and multicenter studies are needed to reveal the role of adropin in ED and the effects of treatment on this molecule.Öğe Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes(Sbem-Soc Brasil Endocrinologia & Metabologia, 2017) Ademoglu, Esra Nur; Gorar, Suheyla; Keskin, Muge; Carlioglu, Ayse; Ucler, Rifki; Erdamar, Husamettin; Culha, CavitObjective: To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Subjects and methods: Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Results: Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Conclusion: Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area.Öğe Structural Changes in the Cerebrum, Cerebellum and Corpus Callosum in Migraine Patients(Canadian Soc Clinical Investigation, 2016) Demir, Berin T.; Bayram, Nezihe A.; Ayturk, Zubeyde; Erdamar, Husamettin; Seven, Pelin; Calp, Aysegul; Sazak, MervePurpose: The purpose of this study was to demonstrate the relationship among the cerebrum, cerebellum and corpus callosum in migraine patients. Methods: This work was conducted with cooperation of the Turgut Ozal Medical Faculty, Department of Anatomy and Neurology. Migraine patients were divided into four groups: new patients; 1-5 years; 5-10 years; and, more than 10 years. All patients (n=75) and control subjects (n=20) underwent Magnetic Resonance Imaging (MRI) and brain images were processed by ONIS and Image J. Data were analyzed using the planimetric method. Results: Cerebrum, cerebellum and corpus callosum volume were calculated for all subjects. The footprints of the callosum were as follows: healthy control subjects, new patients and 1-year patients: 12.8%, 5 years: 11.7% and more than 10 years: 10.7%. The cerebrum volume was as follows: healthy control subjects: 1152 cm(3), 5-10 years: 1102 cm(3) and more than 10 years: 1002 cm(3). Discussion: The results of our study showed atrophy in the cerebrum, cerebellum and corpus callosum of chronic migraine patients. This atrophy was greater in the patients with aura migraines. Conclusion: Our study confirmed that a migraine is an episodic disease that seriously affects the CNS.Öğe THE EFFECT OF DIFFERENT TURKISH SONG COMPOSITIONS ON THE SYMPATHIC AND IMMUNOBIOCHEMICAL PARAMETERS(Nobel Ilac, 2015) Yuksel, Sevda; Kazanci, Fatmanur Hacievliyagil; Ciftci, Sefa; Altan, Merve; Yuksel, Mustafa; Erdamar, Husamettin; Yigitoglu, RamazanObjective: Turkey is a rich country in musical heritage. Studies on the use of music for therapeutic purposes are increasing day by day. The Greek philosophers were convinced that music benefited health and specific recommendations were formulated for using music therapeutically against mental and physical illness. To evaluate the effects of different classical Turkish music styles (Saba, Muhayyer Kurdi, Hijaz, Ussak) on these parameters. Therefore we planned this research to accomplish all of these aims. Material and Method: Venous blood samples were collected before and after music listening and serum levels of serotonin, adrenalin, immunoglobulin A and cortisol were measured. Sixtyone healthy volunteers listened five different kinds of music (popular, rock, arabesque, European classical, classical Turkish music). Results: To compare the same parameters in each volunteer before and after music listening, the Wilcoxon signed-ranks were performed as appropriate. For tests of significance, a p-value of <0.05 was considered to be statistically significant. All parameters were normally distributed. Conclusion: Our Statistical analysis results showed that cortisol level of the people listening Saba style decreased, Immunoglobulin A level decreased for the people who listened popular music and increased for the group listening Nihavent style and adrenaline level increased significantly in all groups except for the people listening Ussak style of music.Öğe The Effects of Valsartan and Amlodipine on the Levels of Irisin, Adropin, and Perilipin(Clin Lab Publ, 2015) Celik, Huseyin Tugrul; Akkaya, Nermin; Erdamar, Husamettin; Gok, Sumeyye; Kazanci, Fatmanur; Demircelik, Bora; Cakmak, MuzafferBackground: Hypertension and obesity are two major threats for public health. Up to the present, antihypertensive medications have been used to lower blood pressure, which seem to provide a better life with lower morbidity and mortality rates. Their effect on etiopathogenesis of hypertension is now an area of developing research. The association between hypertension and obesity also suggests the link between antihypertensive agents and energy hemostasis. We aimed to investigate the effects of antihypertensive treatment on the irisin, adropin, and perilipin levels in patients with essential hypertension and to compare them with healthy volunteers in terms of their effect on energy hemostasis. Methods: In total, 85 newly diagnosed patients with untreated essential hypertension were admitted to the outpatient clinic. Patients were randomized to one of the following treatment protocols: amlodipine or valsartan for a 12 week period. 42 patients were randomized into the valsartan group and 43 patients into the amlodipine group. Serum perilipin, irisin, and adropin levels were measured before and after drug treatment by ELISA kits. Results: We discovered that the hypertensive patients have lower levels of perilipin and higher levels of adropin compared with the control group. Both amlodipine and valsartan increased the levels of perilipin, irisin, and adropin after 12 weeks of treatment. Conclusions: In conclusion, in regulating energy balance, perilipin, irisin, and adropin, could be of pathogenic importance in obesity-induced hypertension. Hence, ongoing trials need to elucidate this mechanism.Öğe The Relationship between Serum Homocysteine Levels and Nonproliferative Diabetic Retinopathy in Type 2 Diabetes Mellitus(Gazi Univ, Fac Med, 2015) Demirci, Huseyin; Onaran, Zafer; Gokcmar, Nesrin; Erdamar, Husamettin; Ornek, NurgulObjective: To evaluate the relationship between serum homocysteine levels and the presence of nonproliferative diabetic retinopathy (NPDR) in type 2 Diabetes Mellitus (T2DM) patients Methods: One-hundred patients with a diagnosis of T2DM and 30 healthy control subjects whose age and sex were similar were included in this study. In diabetic patients retinopathy was assessed by ophthalmological examination. Homocysteine, fasting glucose, HbA1C, triglyceride, total cholesterol, high density lipoprotein and low density lipoprotein levels were analyzed in the blood samples in both groups. Also microalbumin levels were analyzed in 24-hour urine samples. T2DM patients were further divided into two groups according to the presence of retinopathy as patients with NPDR (Group 1, n=32) and without retinopathy (Group 2, n=68). Results: There was no statistically significant difference in the homocysteine levels between the T2DM group and the control group (13.13 +/- 4.35 mu mol/l and 12.29 +/- 4.81 mu mol/l, respectively, p>0.05). Although homocysteine levels were higher in the patients with diabetic retinopathy (Group 1) than the diabetic patients without any diabetic complication (Group 2), the difference was not statistically significant (13.21 +/- 4.23mmol/l and 12.96 +/- 4.60mmol/l, respectively, p>0.05). Conclusion: There was no increase in serum homocysteine levels in T2DM when there was no additional diabetic or cardiovascular complication other than NPDR. Our study, by demonstrating that serum homocysteine level was irrelevant to the presence of NPDR, suggests that homocysteine does not play a role at the early stages of retinopathy.Öğe The Role of Asymmetric Dimethyl Arginine and Nitric Oxide in Patients with Chronic Pancreatitis(Canadian Soc Clinical Investigation, 2015) Cakmak, Muzaffer; Erdamar, Husamettin; Kazanci, Fatmanur; Gok, Sumeyye; Abusoglu, Sedat; Unlu, Ali; Aydin, SafakPurpose: Endothelial dysfunction (ED) is a well-known pathological feature in the development of many diseases. The dysfunctional condition includes reduction in nitric oxide (NO) bioavailability. Chronic pancreatitis (CP) is a progressive and irreversible destruction of pancreas, and may lead to varying degrees of endocrine and exocrine dysfunction. NO released from endothelial cells is thought to be involved in the pathogenesis of CP; however, there is no study investigating the relationship between CP and ED. The purpose of this study was to investigate the levels of NO and methylarginines, including AMDMA, in patients with CP. Patients and Methods: A total of 44 patients with CP and 36 healthy volunteers were included in this study. Serum levels of ADMA, SDMA, NMMA, arginine, and citrulline were analyzed by LC-MS/MS and nitric oxide levels were analyzed using ELISA. Results: Serum SDMA levels were higher in patients with CP (0.55 +/- 0.02 mu mol/L vs. 0.47 +/- 0.02 mu mol/L, p=0.041), whereas NMMA levels were lower in patients with CP (0.052 +/- 0.003 mu mol/L vs 0.068 +/- 0.003 mu mol/L, p<0.001). There was a correlation between the C-reactive protein and SDMA levels (r=0.443, p=0.004). Conclusion: Elevated SDMA and reduced NMMA levels may be responsible for the increased pancreatic damage. Circulating SDMA may be a better marker of stage pancreatic detriment with respect to ADMA or NO in subjects with CP. Further research for possible associations among serum SDMA, ADMA, NO and other measures of pancreatitis may be beneficial in order to better understand the pathophysiology of CP and establish more effective treatment options.
