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    Effect of different selenium levels on thyroid hormone synthesis
    (Refik Saydam National Public Health Agency (RSNPHA) turkhijyen@rshm.gov.tr, 2015) Bal, Ceylan Demir; Büyükşekerci, Murat; Ercan, Müjgan; Hocaoğlu, Asim; Çelik, Hüseyin Tuğrul; Abuşoğlu, Sedat; Tutkun, Engin
    Objective: As an essential element, selenium is very important for thyroid functions. Iodothyronine deiodinase-I is a selenium containing enzyme that is responsible for production of triiodothyronine (T3) from thyroxin (T4) in peripheral tissues. The aim of this study is to investigate the effect of different levels of selenium on thyroid hormone synthesis. Methods: 303 participants who had admitted to several clinics of Ankara Occupational Diseases Hospital and whose serum thyroid hormone and selenium levels were determined between years 2012 and 2014 were separated into 3 groups according to serum selenium levels. Group 1: 50-75?g/L, group 2: 75,1-100?g/L, group 3: 100,1-125?g/L. The thyroid stimulating hormone (TSH), free T3 (FT3) and free T4 (FT4) levels of groups were compared with each other. Results: There was statistically non-significant difference among 3 groups concerning the serum TSH and FT3 levels (p=0,91; p=0,18). Group 3 serum FT4 levels were lower than other groups. FT4 levels of group 3 were significantly different from group 1 (p= 0,005). T3/T4 ratio was significantly higher in group 3 than other groups (p=0,004). There was a negative correlation between selenium and FT4 levels (r=-0,184; p=0,001), whereas a positive correlation existed between selenium and T3/T4 ratio (r=0,178, p=0,002). Conclusion: Selenium has an important role in thyroid functions and FT4 levels increase in selenium deficiency. High FT4 levels should be considered in low selenium levels. © 2015 Elsevier B.V., All rights reserved.
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    Increased serum interleukin-33 levels in patients with Graves' disease
    (2013) Çelik, Hüseyin Tuğrul; Abuşoğlu, Sedat; Burnik, S. F.; Sezer, Sevilay; Serdar, Muhittin A.; Ercan, Müjgan; Uğuz, Nihal
    objective. Interleukin-33 (IL-33), a 30 kDa cytokine, is a member of IL-1 family. It is considered to be an autoimmune biomarker associated with T helper 2 (T 2) response. ?-interferon is also produced by T helper 1 (T 1) cells to induce cellular responses. ?-interferon is a 143-amino acid residue glycoprotein with several biological functions including potent anti-viral activity, stimulation of macrophage activity, modulation of Major Histocompatibilty Complex class I/class II expression, and regulation of a diversity of specific immune responses. Te aim of this study was to investigate the serum levels of IL-33 and ?-interferon in different thyroid disorders. Methods. Twenty patients with Graves' disease, 21 patients with Hashimoto hypothyroidism, 21 euthyroid Hashimoto patients, and 27 control subjects were recruited to this study. Blood samples were drawn and IL-33 and ?-interferon tests were analyzed from 89 participants. Serum IL-33 and ?-interferon analyses were performed by enzyme-linked immunosorbent assay. results. Tere was no statistically significant difference between groups for serum ?-interferon levels. Serum IL-33 concentrations were significantly higher in Graves' disease group compared to the other groups (p<0.000) There was a positive correlation between serum IL-33 and free triiodothyronine (fT3) and thyroxine (fT4). Also, negative correlation between serum IL-33 and thyroid-stimulating hormone (TSH) was statistically significant (p<0.000). Conclusions. Te correlation of serum IL-33 with thyroid hormone levels may be a useful indicator for Graves' disease. These findings may help to make evident the pathophysiologic processes of the autoimmune thyroid diseases and improve therapeutic methods. © 2013 Elsevier B.V., All rights reserved.; MEDLINE® is the source for the MeSH terms of this document.