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Öğe Akut Aort Diseksiyonunda İnflamatuvar İndeksler ve HALP Skorunun Prognostik Değeri(Acil Tıp Uzmanları Derneği, 2025) Özüağ, Alican; Dolanbay, Turgut; Demir, Bilgehan; Nogay, Süleyman; Mamur, Ömer SerdarGiriş: Aort diseksiyonu kritik bir klinik tablodur ve son yıllarda yapılan çalışmalar, tanısal BT anjiyografinin yanında laboratuvar parametrelerinin prognostik değerini giderek daha fazla vurgulamaktadır. Gereç ve Yöntem: Bu çalışmaya Ocak 2023 – Ocak 2025 tarihleri arasında aort diseksiyonu tanısı alan 23 erişkin hasta dâhil edilmiştir. Hastaların başvuru anındaki laboratuvar verileri ve bu verilerden türetilen skorlar ile mortalite ve yoğun bakım yatış süresi gibi klinik sonuçlar arasındaki ilişki değerlendirilmiştir. Bulgular: Mortalite gelişen hastalarda nötrofil sayısı anlamlı olarak daha yüksek bulunmuştur (p = 0.03) ve mortaliteyi öngörmede %57.1 duyarlılık ve %68.8 özgüllük göstermiştir. HALP skoru ile yoğun bakım yatış süresi arasında anlamlı negatif korelasyon saptanmıştır (r = –0.471, p = 0.023). Buna karşılık, CRP düzeyleri ile yoğun bakımda kalış süresi arasında anlamlı pozitif korelasyon mevcuttur (r = 0.504, p = 0.014). Sonuç: Nötrofil sayısı, HALP skoru ve CRP düzeyleri, aort diseksiyonunun prognozunun öngörülmesinde ve erken risk sınıflandırmasında yararlı biyobelirteçler olarak kullanılabilir.Öğe Delta neutrophil index, CRP/albumin ratio, procalcitonin, immature granulocytes, and HALP score in acute appendicitis: Best performing biomarker?(De Gruyter Poland Sp Z O O, 2025) Cumaoglu, Mustafa Oguz; Ayan, Durmus; Vural, Abdussamed; Dolanbay, Turgut; Ozbey, Caner; Kulu, Abdul RidvanAim- This study investigates the diagnostic accuracy of five inflammatory biomarkers - delta neutrophil index (DNI); C-reactive protein/albumin ratio (CAR); procalcitonin (PCT); immature granulocytes count (IGc); and hemoglobin, albumin, lymphocyte, platelet score (HALPs) - in detecting acute appendicitis (AA) and identifying the most reliable marker for distinguishing complicated from non-complicated cases. Materials and methods- A prospective, cross-sectional study was conducted in a tertiary hospital emergency department, including 100 histopathologically confirmed AA patients and 100 healthy controls. Biomarker levels were analyzed using receiver operating characteristic curves. Sensitivity, specificity, and optimal cut-off values were determined via the Youden index, while logistic regression identified independent predictors of complicated appendicitis (CA). Results- DNI exhibited the highest diagnostic accuracy for AA (AUC: 0.87, 95% CI: 0.821-0.919, p < 0.001) with 92% specificity and 69% sensitivity at a cut-off of 71.88. CAR (AUC: 0.853) and PCT (AUC: 0.852) showed similar performance, whereas IGc (AUC: 0.695) and HALPs (AUC: 0.627) were less effective. DNI also outperformed the Alvarado score in predicting CA (AUC: 0.698 vs 0.626) and was an independent predictor (OR: 3.18, 95% CI: 1.40-7.24, p = 0.006). Conclusions- DNI demonstrated superior diagnostic performance for AA and was the most reliable marker for identifying CA. Its integration into clinical practice may enhance early diagnosis and reduce unnecessary surgeries, improving outcomes.Öğe Demographic, Sociocultural, and Time-Related Patterns of Violent Suicide Attempts(Int Scientific Information, Inc, 2025) Cumaoglu, Mustafa Oguz; Vural, Abdussamed; Dolanbay, Turgut; Dogan, Mustafa; Sekme, SabriBackground: Violent suicide attempts (VSAs), characterized by high-lethality methods such as hanging, firearms, and sharpobject injuries, are a significant public health concern. While VSAs are widespread globally, research on their associated factors remains limited. This study investigated demographic, sociocultural, and environmental factors influencing VSAs in Turkey's southern region, emphasizing time-related and seasonal patterns, to guide public health strategies. Material/Methods: Data were retrospectively collected from 86 VSA patients admitted to Nigde University Hospital between January 1 and December 31, 2023. Parameters assessed included demographics, marital status, education, psychiatric history, suicide methods, time of day, weekday trends, and seasonal environmental factors like temperature, precipitation, and wind speed. Statistical analyses revealed meaningful associations between sociodemographic characteristics, clinical features, and environmental factors and patterns of violent suicide attempts. Results: VSAs were more frequent among men, single people, and divorced individuals. Gender differences emerged in suicide methods: men predominantly used hanging and firearms, while women favored sharp objects. Psychiatric disorders were significantly less common among married individuals compared to single people and divorcees. VSAs were more prevalent on weekdays, peaking in the morning, with fatality rates highest in the afternoon. Seasonal analysis revealed spring as the peak period for VSAs, correlated with higher precipitation and wind speeds. Conclusions: The findings show the role of demographic, psychiatric, and environmental factors in VSA patterns. High-risk groups include single and divorced individuals and those with psychiatric disorders. Tailored interventions addressing seasonal and time-related patterns and enhancing support networks could mitigate VSA risks. Improved mental health services and targeted public health policies are essential for effective suicide prevention.Öğe Enhanced stroke prediction after transient ischemic attack: the role of triglycerides and free thyroxine: A retrospective cohort study(Lippincott Williams & Wilkins, 2025) Cumaoglu, Mustafa Oguz; Vural, Abdussamed; Dolanbay, Turgut; Ozguner, Hilal; Avcuoglu, EmrahTransient ischemic attack (TIA) carries a substantial risk of early ischemic stroke, particularly within the first 48 hours. Although the ABCD(2) scoring system is widely used for short-term risk stratification, its exclusion of laboratory markers may limit predictive accuracy. To investigate whether selected biochemical markers - thyroid function tests, lipid profiles, and Hemoglobin A1c - hold prognostic value for early post-TIA stroke, and whether their integration enhances the predictive performance of the ABCD(2) scoring system. This retrospective cohort included 130 first-ever TIA patients admitted between March 2022 and 2024. ABCD(2) scores and laboratory parameters were recorded at admission. Patients were followed for 30 days and categorized based on stroke timing: early (<= 48 hours), intermediate (3-7 days), and late (8-30 days). Receiver operating characteristic (ROC) curve analysis and binary logistic regression were utilized to assess predictive performance and determine independent risk factors. Ischemic stroke occurred in 52 patients (40%) within 30 days, with 65% of events arising in the first 48 hours. Patients who developed stroke had significantly elevated triglyceride (TG) levels (P = .038), while those with early stroke exhibited significantly lower free thyroxine (fT4) levels (P < .001). ROC analysis identified TG >= 152 mg/dL (area under the curve (AUC): 0.607) and fT4 <= 1.17 ng/dL (AUC: 0.708) as critical thresholds. Integration of these biomarkers into the ABCD(2) model significantly improved its performance: the AUC rose from 0.647 (ABCD(2) alone) to 0.751 (with TG) and 0.775 (with fT4). Notably, fT4 demonstrated a high negative predictive value (88.6%) for ruling out early stroke. Elevated TG and reduced fT4 levels were independently associated with increased stroke risk after TIA. Incorporating these biomarkers into the ABCD(2) scoring system significantly enhanced early stroke prediction. In particular, low fT4 may serve as a robust marker to exclude high-risk cases. These findings support a multimodal risk stratification strategy incorporating clinical, biochemical, and imaging data. Validation through prospective multicenter studies is recommended.Öğe Evaluation of Tube Thoracostomy Training Videos on YouTube: Educational Quality, Reliability, and Popularity(Sage Publications Inc, 2026) Ari, Demet; Ari, Murat; Akbas, Ilker; Dolanbay, Turgut; Kartal, BilalBackground: Tube thoracostomy is a critical procedure commonly performed in emergency and trauma settings to manage life-threatening conditions such as pneumothorax and hemothorax. As digital platforms become increasingly integrated into procedural education, YouTube has become a widely used supplementary learning resource. However, the educational quality and reliability of its content remain variable. This study evaluates YouTube tube thoracostomy training videos on educational quality, reliability, and popularity. Methods: This cross-sectional observational study evaluated YouTube videos related to tube thoracostomy using predefined search terms. After screening and applying inclusion and exclusion criteria, 79 videos were included in the analysis. Data collected included video duration, view count, like count, subscriber count, uploader type (institutional or individual), country of upload, and presence of spoken narration. Educational quality and reliability were evaluated using the Global Quality Scale (GQS), DISCERN, and Journal of the American Medical Association (JAMA) criteria. Video popularity was assessed using the adapted Video Power Index (VPI). Results: Of the analyzed videos, 67.1% were uploaded by individuals and 32.9% by institutional sources. Videos featuring spoken narration, longer duration, and institutional origin demonstrated significantly higher GQS and DISCERN scores and greater popularity indicators (P < .05). Institutional videos exhibited higher educational quality than those uploaded by individuals. However, a direct correlation between video popularity and educational quality was not consistently observed. Conclusion: The educational quality of tube thoracostomy training videos on YouTube varies considerably. Institutional videos of longer duration with spoken narration provide greater educational value. These resources should serve only as supplementary tools and not replace hands-on training. Establishing quality standards for medical training videos and promoting institutional content production are recommended.Öğe Examination of the APELIN signaling pathway in acetaminophen-induced hepatotoxicity in rats(Walter de Gruyter Gmbh, 2025) Dolanbay, Turgut; Makav, Mustafa; Gul, Huseyin Fatih; Karakurt, Emin; Bektasoglu, FikretObjectives The present study identifies the level changes of markers (Apelin, Elabela, Meteorin, ALT, AST, GGT) in the liver after acute intake of high-dose paracetamol and their role in determining liver damage. Methods The rats were categorized into two groups (Control and Toxication), each consisting of seven rats. Apelin, Elabela, Meteorin, ALT, AST and GGT levels were determined in liver tissue. The levels of Apelin, Elabela, and Meteorin in liver tissue homogenate were assessed following the kit procedure, utilizing commercial enzyme-linked immunosorbent assay. ALT, AST and GGT analyzes were performed from liver tissue homogenate with Erba colorimetric kit according to the kit procedure. It was also evaluated histopathologically from liver tissue. Results Looking at the findings, a significant decrease was determined in the Elabela and Meteorin data in the Apap group compared to the control group. In the Apelin data, a statistical increase was observed in the Apap group compared to the control group. A significant increase in ALT analysis was detected in the APAP group compared to the control group. Considering GGT and AST data, a statistical increase was detected in the APAP group compared to the control group.While Bax, Bcl-2 and iNOS immunoreactivity was not observed in the control group, a yellowish-brown positive reaction was detected in the cytoplasm of degenerated and necrotic hepatocytes, especially around the vena centralis, in the paracetamol group. Conclusions As a result, it is thought that Apelin, Elabela and Meteorin markers may be decisive markers in determining toxicity in liver damage.Öğe Hospitalized Recurrent Deep Vein Thrombosis: Demographic, Clinical, and Laboratory Insights from a Single-Center Retrospective Study(Kafkas Üniversitesi, 2025) Cumaoglu, Mustafa Oguz; Dolanbay, Turgut; Vural, Abdussamed; Yüceer, Ömer; Tuncar, Alpay; Yanmaz, Seyyid Rasim[Abstract Not Available]Öğe IMPACT OF HEMOGLOBIN-ALBUMIN-LYMPHOCYTE-PLATELET (HALP) SCORE ON MORTALITY IN ABOVE-ANKLE AMPUTATION OF DIABETIC FOOT INFECTION(Dokuz Eylul Univ Inst Health Sciences, 2025) Yagar, Hilal; Vural, Abdussamed; Dolanbay, TurgutPurpose: Diabetic foot ulcers are one of the important reasons for amputations. The hemoglobin-albumin-lymphocyte-platelet (HALP) score is a marker of the inflammatory and nutritional status of the individual. Aim of this study is to investigate the relationship between the HALP score and mortality in patients undergoing above-ankle amputation due to diabetic foot infection. Material and Methods: The demographic data (age, sex), deaths during hospitalization, laboratory values and mortality through 3-6-9-12 months were recorded. Chi square and t test were used for categorical comparison and logistic regression tests were used for mortality risk estimation. Results: The mortality rates in hospital and in the 3rd, 6th, 9th, and 12th months were 13.1%, 37.7%, 48.5%, 53.8%, and 56.2% respectively. HALP score below 21.55 was associated with a 2.975 times higher risk for 1-year mortality (odds ratio: 2.975; 95% CI: 1.252-7.069; p = 0.014). Female gender, HALP score below 21.55, and age over 65 predict 20.2% overall 1-year mortality risk (Nagelkerke R2 = 0.202). Conclusion: The HALP score is a novel risk factor for mortality in patients undergoing amputation for diabetic foot ulcers. Also; older age and female gender are independent risk factors for 1-year mortality.Öğe Inflammatory indices as independent predictors of in-hospital mortality in acute upper gastrointestinal bleeding(Bmc, 2026) Cumaoglu, Mustafa Oguz; Vural, Abdussamed; Alpaslan, Mustafa; Dolanbay, Turgut; Kulu, Abdul Ridvan; Sezgin, Ercan; Yanmaz, Seyyid RasimBackground Acute upper gastrointestinal bleeding (UGIB) remains a high-risk emergency with non-negligible in-hospital mortality. Inflammatory indices derived from routine admission tests may provide additional bedside information reflecting inflammatory burden and physiologic reserve, but their prognostic value in UGIB is not well defined. Methods In this retrospective single-center observational study, 502 consecutive adults admitted via the emergency department with UGIB (December 2022-2024) were analyzed. Demographic, clinical (including melena/hematemesis), comorbidity, bleeding etiology (variceal vs. non-variceal), endoscopy-related variables when available, transfusion status, and laboratory data were extracted from electronic records. Platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), and neutrophil-to-albumin ratio (NAR) were calculated at admission. Predictors of in-hospital mortality were assessed using ROC analysis and logistic regression; two multivariable models were reported to address overlap between melena and hematemesis. Results Overall in-hospital mortality was 9.4% (47/502). Non-survivors had lower admission hemoglobin, albumin, and platelet counts and higher INR. PLR, PNI, and NAR were associated with mortality in univariable analyses. In multivariable Model 1 (including melena), low PLR (OR = 4.734, 95% CI = 2.352-9.529; p < 0.001), low PNI (OR = 3.041, 95% CI = 1.488-6.216; p = 0.002), lower hemoglobin (OR = 0.896 per 1 g/dL increase, 95% CI = 0.809-0.992; p = 0.035), and melena (OR = 2.318, 95% CI = 1.131-4.747; p = 0.022) were independently associated with mortality. In Model 2 (melena replaced by hematemesis), low PLR (OR = 3.890, 95% CI = 1.894-7.989; p < 0.001), hematemesis (OR = 4.922, 95% CI = 2.385-10.157; p < 0.001), and lower hemoglobin (OR = 0.900 per 1 g/dL increase, 95% CI = 0.811-0.998; p = 0.046) remained significant, whereas PNI and NAR were not independently associated. ROC discrimination for PLR/PNI/NAR was modest (AUC 0.612/0.604/0.594, respectively), indicating limited stand-alone predictive performance. Conclusion Admission PLR showed the most consistent independent association with in-hospital mortality across alternative multivariable models, while the independent contribution of PNI appeared model-dependent. Given the modest AUCs, these indices should be interpreted as adjunctive markers alongside clinical and endoscopic assessment rather than as stand-alone predictors. Prospective multicenter studies with standardized data capture are warranted to evaluate their incremental value within established UGIB risk stratification pathways.Öğe Investigation of blood parameters as predictors in diagnosing acute scrotum(Kare Publ, 2025) Demir, Bilgehan; Nogay, Suleyman; Dolanbay, Turgut; Polat, Muhammed Eyyub; Akdemir, EnderOBJECTIVE: Acute Scrotum (AS) is defined as pain associated with swelling and redness of the scrotum. This study investigates the hemogram and C-Reactive Protein (CRP) values obtained from patients diagnosed with AS, based on the hypothesis that blood parameters can be used as biomarkers in the diagnosis of Testicular Torsion (TT). The aim was to evaluate the predictability of these parameters in diagnosing AS in both pediatric and adult age groups. METHODS: Demographic data and blood parameters including Hemoglobin (Hb), Platelet (PLT), CRP, and White Blood Cell (WBC) levels of patients who presented to our Emergency Department with the diagnosis of AS (TT, epididymitis, varicocele) and received medical and surgical treatment were analyzed. The importance of these parameters in diagnosis was assessed. RESULTS: A total of 26 patients were included in the study. The mean age of the cases was 15.8 +/- 3.6 years. 20 of the patients (76.9%) were in the pediatric age group, while 6 (23.1%) were in the adult age group. 93.1% (27) of the cases were unilateral, while 6.9% (2) had bilateral acute scrotum symptoms. The highest incidence of cases occurred in spring with 9 cases (31%), followed by winter and summer with 7 cases each (24.1%), and autumn with 6 cases (20.7%). Significant differences in age, platelet, and hemoglobin levels were observed between the pediatric and adult age groups. CONCLUSION: In conclusion, this study highlights significant age-related differences in the diagnosis and treatment of AS. The higher requirement for surgical intervention in pediatric patients further emphasizes the importance of early diagnosis and timely intervention. However, further studies with larger sample sizes are needed to validate these findings and better understand the etiological differences. Additionally, a more specific analysis of blood parameters in subgroups (such as epididymitis, orchitis, TT) under the term acute scrotum may contribute to the literature.Öğe Investigation of the Effect of Gender on Blood Parameters in Acute Renal Failure in Patients Presenting to the Emergency Department of a Hospital(Acil Tıp Uzmanları Derneği, 2025) Demir, Bilgehan; Dolanbay, Turgut; Nogay, Süleyman; Tan, Fatih; Öngenli, Ömer FarukAim: Acute renal failure (ARF) is a sudden change in renal function that prevents the excretion of nitrogenous wastes and disrupts the body's fluid and electrolyte balance. Identification of ARF risk factors and development of indicators that predict mortality are crucial to improve the success of medical care. We aim to evaluate the effect of age and gender factors in patients with ARF and to evaluate the course and frequency of the disease in female patients compared to male patients. Methods: The data of adult patients over 18 years of age who were hospitalized with a diagnosis of ARF between 01.02.2025-01.03.2025 in the emergency department of Malatya Training and Research Hospital were retrospectively analyzed. Blood laboratory parameters were recorded and analyzed to determine whether these data were positively or negatively associated with gender. Results: A statistically significant difference was found between age and gender in patients with ARF (p= 0.004). Female patients with ARF were older than male patients. There was a statistically significant relationship between creatinine level and gender in patients with ARF (p=0,017). Creatinine levels were higher in male ARF patients. There was no statistically significant difference between plt, hb, htc, ALT and HALP score and gender (p values 0.384; 0.078; 0.221;0.221; 0.189; 0.174, respectively). Conclusions: The finding in our study that ARF occurs at older ages compared to men may be explained by the interaction of biological, hormonal, clinical and sociocultural factors. The renal protective effects of estrogen are realized through protection of vascular structure, support of glomerular iltration rate (GFR) and reduction of oxidative stress. However, the decrease in estrogen levels in the postmenopassusal period may be an important factor in the more rapid deterioration of renal function. The pro-inflammatory properties of testosterone and increased oxidative stress, as well as the earlier development of hypertension, atherosclerosis and chronic kidney disease in men, may be another reason why ARF occurs at a younger age in men compared to women.We found that creatinine levels were significantly higher in male patients with ARF compared to female patients. Men are known to have more muscle mass in general compared to women and this may lead to higher creatinine levels in men.Öğe LESSONS LEARNED FROM THE FEBRUARY 6, 2023, KAHRAMANMARAS EARTHQUAKES: A SPECIAL REPORT FROM EMERGENCY PHYSICIANS(Via Medica, 2026) Al, Behcet; Akbas, Ilker; Karakus, Ali; Dolanbay, Turgut; Demir, Bilgehan; Acar, Demet; Lok, UgurINTRODUCTION: To present field-based challenges, observations, and practice-oriented recommendations derived from the experiences of emergency physicians involved in the response to the February 6, 2023, Kahramanmaraş earthquakes. MATERIAL AND METHODS: This Special Report is based on professional experiences, field observations, and expert consensus developed during and after the disaster. Insights were obtained through in-person meetings, online discussions, and post-deployment debriefings with twenty-six emergency medicine physicians deployed across four severely affected cities. Recurrent operational challenges and key themes were identified through iterative, consensus-based synthesis and organized into a phase-based framework encompassing preparedness, acute response, and recovery. RESULTS: The synthesis yielded a practical framework structured across three disaster phases, outlining recurrent challenges and actionable considerations relevant to emergency healthcare delivery. Key issues included coordination and communication gaps, workforce deployment and safety, surge capacity, logistics, and continuity of care across affected regions. CONCLUSIONS: Experience-informed, phase-based guidance can support emergency physicians and health systems in strengthening disaster preparedness and response. This field-derived framework aims to inform future planning, training, and coordination strategies for large-scale emergencies. © 2026 Via MedicaÖğe Metabolic risk factors associated with premature myocardial infarction in adults ≤ 35 years: a case-control study(Bmc, 2026) Vural, Abdussamed; Dolanbay, Turgut; Cumaoglu, Mustafa Oguz; Elbasan, Zafer; Yuceer, Omer; Sekme, SabriBackground Acute myocardial infarction (AMI) in very young adults (<= 35 years) represents a distinct clinical entity with limited evidence. This study aimed to characterize metabolic risk factors differentiating young AMI patients from clinic-based controls. Methods This single-center retrospective case-control study included 62 consecutive young adults (aged 18-35 years) with confirmed AMI and 60 clinic-based controls selected from cardiology outpatient clinics during the same study period. Controls were selected using age (+/- 2 years) and sex restrictions to ensure group-level comparability with the AMI cohort. Metabolic parameters, including body mass index (BMI), LDL cholesterol, and blood glucose, were compared between groups. Effect sizes (Cohen's d) were calculated to assess clinical significance. Multivariable logistic regression was performed to identify independent predictors of AMI. Correlation analyses (Pearson or Spearman, as appropriate) were performed to examine relationships between metabolic markers. Results Young AMI patients demonstrated a significantly more unfavorable metabolic profile than controls: median BMI (26.5 vs. 23.9 kg/m & sup2;, p < 0.001), LDL cholesterol (136.5 vs. 108.0 mg/dL, p = 0.002), and blood glucose (120.0 vs. 95.0 mg/dL, p < 0.001). All three metabolic parameters showed large effect sizes (d > 1.0), indicating clinically substantial differences. In multivariable analysis, BMI (adjusted OR 1.28 per kg/m & sup2;, 95% CI 1.08-1.52), LDL cholesterol (adjusted OR 1.14 per 10 mg/dL, 95% CI 1.01-1.29), and blood glucose (adjusted OR 1.16 per 10 mg/dL, 95% CI 1.05-1.29) remained independently associated with AMI risk. LDL cholesterol showed a statistically significant, albeit weak, positive association with peak troponin levels (rho = 0.296, p = 0.020). Among AMI cases, STEMI patients exhibited higher acute glucose levels than NSTEMI patients (p = 0.004). Conclusion Very young adults (<= 35 years) with AMI exhibit markedly elevated BMI, LDL cholesterol, and glucose levels compared to age- and sex-comparable controls with large effect sizes supporting clinical significance. Multivariable analysis confirmed independent associations for all three metabolic parameters. These traditional modifiable risk factors continue to be strongly associated with early myocardial infarction, emphasizing the importance of aggressive metabolic screening and early prevention strategies in very young populations.Öğe Prognostic Role of Blood Parameters in Subarachnoid Hemorrhage: A Retrospective Study(Kafkas Üniversitesi, 2025) Demir, Bilgehan; Dolanbay, Turgut; Nogay, Süleyman; Kartal, Bilal[Abstract Not Available]Öğe Rare cause of chest pain: Megaesophagus forming achalasia(Kuwait Medical Assoc, 2026) Cumaoglu, Mustafa Oguz; Dolanbay, Turgut; Bolat, HaciAchalasia is esophageal motor dysfunction caused by impaired relaxation of the lower esophageal sphincter. A 77-year-old female patient was brought to the emergency department with complaints of nausea, vomiting and chest pain. Thorax computed tomography (CT) imaging was performed because there was no abnormality in troponin and electrocardiogram (ECG) follow-ups; approximately 7 cm diameter megaesophagus was detected. Endoscopy was performed for advanced diagnosis and treatment. Diagnosis of achalasia was confirmed by endoscopy. The distal end of the esophagus was widened by dilatation. The patient was discharged after 24 hours of service follow-up. Although it is a rare condition in elderly patients presenting to the emergency department, it should be noted that achalasia will constitute a non-cardiac chest pain clinic.Öğe Saddle pulmonary embolism in a patient with atypical clinical presentation: a case report(Kuwait Medical Assoc, 2026) Vural, Abdussamed; Dolanbay, Turgut; Ozcelik, MustafaSaddle pulmonary embolism (PE), which is a rare form of acute PE, can cause sudden hemodynamic deterioration and death. In this case, we present a female patient who presented to the emergency department with complaints of back pain and was found to have sinus bradycardia on electrocardiogram, ultimately diagnosed with saddle PE. A chest computed tomography was ordered to evaluate for a possible lung infection. Although no evidence of pneumonia was found, the imaging showed an enlarged diameter of the pulmonary artery measuring 3.22 cm. Saddle PE is a condition that should be considered in the diagnosis in the Emergency Department as it can lead to serious mortality and morbidity, and may not always present with typical symptoms. In cases with atypical presentation where PE is not initially suspected, the high diameter of the main pulmonary artery detected on chest CT scans should be associated with diseases with right ventricular overloading such as PE.Öğe The Effectiveness of Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and Model for End-Stage Liver Disease (MELD) Score in Predicting Prognosis in Portal Vein Thrombosis, a Pilot Study(Mdpi, 2026) Yumrutepe, Sevgi; Dolanbay, Turgut; Nogay, Suleyman; Demir, Bilgehan; Polat, Muhammed EyyubBackground/Objectives: Portal vein thrombosis (PVT) is a clinically significant condition in which early risk stratification remains challenging, particularly in emergency settings where rapid decision-making is required. This study aimed to evaluate the prognostic value of the Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and the Model for End-Stage Liver Disease (MELD) score in predicting the need for intensive care in patients with PVT. Methods: A retrospective analysis was conducted on adult patients (>18 years) diagnosed with PVT in the emergency department between January 2018 and December 2024. A total of 29 patients meeting the inclusion and exclusion criteria were included. Demographic characteristics, laboratory parameters, Intensive Care Unit (ICU) admission status, and 90-day mortality were analyzed. The sensitivity and specificity of MELD, SII, and SIRI for predicting ICU admission were calculated. Non-normally distributed variables were expressed as median (interquartile range, IQR) and compared using the Mann-Whitney U test. Results: The mean age of patients was 60.5 +/- 16.2 years, and 18/29 (62.1%) were male. ICU admission was required in 9/29 (31.0%) of cases. MELD score (median 18.7 [11.0-21.9] vs. 7.9 [6.7-13.5], p = 0.003), bilirubin (median 2.4 [1.0-4.2] vs. 0.7 [0.4-1.1], p = 0.016), and SIRI (median 6.4 [2.3-21.3] vs. 1.4 [0.6-9.3], p = 0.038) were significantly higher in ICU-admitted patients. MELD score showed 66.7% sensitivity and 95% specificity, while SIRI had 88.9% sensitivity and 55% specificity for ICU prediction. Conclusions: MELD score, bilirubin, and SIRI are significantly associated with ICU admission in PVT patients. Their integration into emergency department protocols may assist in early risk stratification and resource allocation.Öğe The Effects of Honeybee Venom Intoxication on the Cardiovascular System in Rats(Springernature, 2025) Sahin, Levent; Makav, Mustafa; Dolanbay, Turgut; Dag, Serpil; Yildiz, AyferObjectiveThe objective of this study was to examine the effects of bee venom (BV), which contains many enzymes, peptides, and amines, on the cardiovascular system in rats.Materials and MethodsThe animal material of the study included 24 Wistar albino rats in total, divided into the control, low dose (20 mu g/g-mg/kg) BV, and high dose (30 mu g/g-mg/kg) BV groups. Heart rate, PR, QRS, and QTc interval values were recorded in the electrocardiography (ECG) examinations of the rats. Blood samples were collected for biochemical analyses, and heart tissue samples were collected for histopathological analyses.ResultsAccording to the ECG data, heart rate values decreased at the 6th h in both the 20 and 30 mg BV groups. The PR interval value increased at the 6th h in both the 20 and 30 mg BV groups in comparison to the control group. Compared to the control group, the troponin and creatine kinase (CK) values of the 20 and 30 mg BV groups significantly increased. Furthermore, creatine kinase myocardial band (CK-MB) and lactate dehydrogenase (LDH) values increased in both the 20 and 30 mg BV groups compared to the control group. Heart tissues taken from both groups administered BV were hyperemic, and hemorrhagic areas were detected in the heart tissues of some rats in the group administered 30 mg BV.ConclusionBV has a dose-independent bradycardic effect and increases cardiac enzymes while adversely affecting heart tissue at high doses.Öğe The prognostic value of HALP, SII, and SIRI scores in patients with acute calculous cholecystitis(2026) Dolanbay, Turgut; Demir, Bilgehan; Gonultas, Fatih; Gökçe, Hasan; Nogay, Süleyman; Özkan, Asiye; Kaya, DavutAcute cholecystitis (AC) is a common surgical emergency, usually developing secondary to gallstones and characterized by gallbladder inflammation. Although classical biomarkers such as leukocyte count and C-reactive protein (CRP) are widely used for diagnostic purposes, composite inflammation-based indices such as Hemoglobin, albümin, lenfosit ve trombosit (HALP), Systemic immune-inflammation index (SII), and Systemic Inflammatory Response Index (SIRI) have recently emerged as important prognostic markers. This study aims to evaluate the association of HALP, SII, and SIRI scores with clinical outcomes [hospital length of stay, Internal care unit (ICU) requirement, and gallstone presence] in adults hospitalized with acute cholecystitis. A total of 88 patients hospitalized with acute cholecystitis between January 2020 and December 2024 were included. Demographic data, admission laboratory parameters, and HALP, SII, and SIRI scores were retrospectively analyzed. Correlation tests and Receiver Operating Characteristic (ROC) analysis were performed to assess prognostic performance. No statistically significant association was observed between HALP, SII, and SIRI scores and either length of hospital stay or intensive care unit requirement (p>0.05). In contrast, WBC levels showed a positive correlation with both parameters and were significantly higher in patients requiring intensive care (p=0.035). In ROC analysis, the Area Under the Curve (AUC) value for Leukocyte (WBC) was determined as 0.859. The significant increase in CRP and glucose levels in patients with acute cholecystitis acalculus suggests that this variant is associated with a more pronounced inflammatory process. In this study, traditional biomarkers especially WBC were more predictive of prognosis in acute cholecystitis than composite inflammation scores. Further time-series, prospective, and multicenter studies are warranted to validate the clinical utility of indices such as HALP, SII, and SIRI.Öğe The Role of Blood Parameters and Inflammatory Scoring Systems in Prognostic Prediction in Pediatric Appendicitis Patients(Wiley, 2026) Nogay, Suleyman; Gonultas, Fatih; Dolanbay, Turgut; Demir, Bilgehan; Bayrakci, Ercan; Gol, Murat; Ongenli, Omer FarukBackground: Acute appendicitis is one of the most common surgical emergencies in childhood. Its clinical management poses particular challenges in younger age groups. Blood parameters and inflammatory scoring systems have recently been investigated as promising biomarkers for prognostic prediction. However, the number of studies addressing this issue in the pediatric population remains limited. Methods: This study was conducted retrospectively, and pediatric patients diagnosed with acute appendicitis were included. Hematological parameters (WBC, HGB, NEU%, LYM, and PLT), biochemical markers (ALB, CRP, and GLC), and inflammatory indices (NLR, LAR, HALP, SII, SIRI, and WAR) were analyzed. The findings were evaluated in relation to complications (perforation, abscess, and mesenteric inflammation), length of hospital stay, and appendiceal diameter measured by ultrasonography. ROC analyses were performed to assess prognostic factors. Results: The HALP score was found to be significantly higher in patients without perforation (p = 0.048). NEU%, NLR, and SII values were elevated in patients with abscess formation, whereas LYM, LAR, and HALP were higher in those without abscess (p < 0.05). HGB, ALB, and HALP levels were significantly higher in patients without mesenteric inflammation, indicating an inverse relationship with the severity of inflammation. No correlation was observed between blood parameters and length of hospital stay; however, a weak but significant positive correlation was found among WBC, HGB, NEU%, NLR, SII, SIRI, and appendiceal diameter. ROC analysis demonstrated that HGB and HTC had moderate discriminative ability for mesenteric inflammation (AUC = 0.70), whereas GLC, NLR, and SII showed strong discriminative performance for abscess prediction (AUC = 0.84, 0.88, 0.93). Conclusion: Our findings suggest that HALP, NLR, and SII may hold prognostic value in pediatric patients with appendicitis. However, these parameters alone are insufficient and should be interpreted in conjunction with clinical and imaging findings. Validation of the results in larger, multicenter studies is required.
