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Öğe Acute effects of caffeine on choroidal thickness and ocular pulse amplitude(Taylor & Francis Ltd, 2016) Dervisogullari, Mehmet Serdar; Totan, Yuksel; Yuce, Aslihan; Kulak, Ali EnderObjective: To explore ocular changes in healthy people after caffeine consumption.Methods: This prospective observational study was carried out with students of the Turgut ozal University Medical Faculty from May 15 to 15 December 2014. Enrolled in the study were 17 healthy subjects (n=17 eyes), with a median age of 24 (IQR 1), ranging between 21 and 26 years. The control group (6 females, 11 males) aged between 23 and 28 (median 25 years [IQR 4.75]). For study, one eye from each participant was randomly selected. To obviate the effect of diurnal variations, tests were performed at the same time of the day (10:00a.m.-12:00p.m.). Each subject was given an ophthalmologic examination before the study to exclude those with undiagnosed ocular disease. Version 6.0 Cirrus high-definition optical coherence tomography (HD-OCT) (Carl Zeiss Meditec, Dublin, CA) was used to measure CT at the fovea, and 1500m nasal and 1500m temporal to the fovea. After baseline OCT measurements, participants were asked to have 200mg oral caffeine intake or a placebo capsule (200mg lactose powder). Two further OCT measurements were applied at the first and fourth hours of caffeine intake. All participants also had intraocular pressure (IOP) and ocular pulse amplitude (OPA) measurements recorded before, first and fourth hours of caffeine intake. IOP and OPA were measured using the dynamic contour tonometry (DCT) (Swiss Micro Technology AG, Port, Switzerland).Results: The groups showed no significant difference by means of age, gender, spherical refraction and axial length (p>0.05). Baseline choroidal thickness measurements of the study and control group showed no significant difference. Oral caffeine intake caused a significant reduction in choroidal thickness compared with baseline, at all three measurement points, (p<0.05). There were no significant changes in IOP and OPA measurements compared with the baseline values (p>0.05). The choroidal thickness still continued to decrease for at least 4h following caffeine intake; whereas, the difference between 1 and 4h was not statistically significant (p>0.05). However, choroidal thicknesses, IOP and OPA values of the control group revealed no significant difference at all points when comparing measurements at baseline with 1 and 4h after placebo intake (p>0.05).Conclusions: We found no significant change in IOP and OPA following oral 200mg caffeine intake, while CT significantly decreased, for at least 4h.Öğe Brilliant Blue G assisted Epiretinal Membrane Surgery(Nature Portfolio, 2014) Totan, Yuksel; Guler, Emre; Dervisogullari, Mehmet SerdarWe report intensely staining epiretinal membrane (ERM) with Brilliant Blue G (BBG) under air for two minutes. ERM peeling was performed in 21 cases. After removal of posterior hyaloid, 0.2 mL BBG was first applied on the macula, to stain ERM under air conditions for 2 minutes. Internal limiting membrane (ILM) was intensely stained and peeled in all cases following ERM removal. In 4 cases, the ERM was also observed to be intensely stained with BBG and peeled with an ILM forceps. Postoperatively, the ganglion cell layer thickness was lower in three of the cases, however VA improved in all cases and multifocal electroretinogram revealed no toxicity. Light microscopy of ERM revealed masses of cells whereas; the ILM did not. The increased staining characteristics of ERM and ILM may be resulted from longer contact time of BBG under air pressure.Öğe Choroidal thickness measurement in healthy pediatric population using Cirrus HD optical coherence tomography(Consel Brasil Oftalmologia, 2015) Tenlik, Aylin; Guragac, Fatma B.; Guler, Emre; Dervisogullari, Mehmet Serdar; Totan, YukselPurpose: To investigate the association between central choroidal thickness (CT), axial length (AL), age, gender, and refractive error in a healthy pediatric population using optical coherence tomography (OCT). Methods: This institutional study involved 137 healthy children (57 boys, 80 girls) aged between 4 and 18 years. Each child underwent a dilated eye examination, cycloplegic refraction, and AL measurement using a Nidek AL-Scan optical biometer. The central foveal thickness (CFT) and CT were measured using Cirrus high definition (HD)-OCT. The right eye of each subject was selected for analysis. Results: The mean age of the children was 10.0 +/- 4.7 years (range, 4-18 years). The mean spherical equivalent (SE) was -0.24 +/- 1.24 diopters (D) (range, -2.00 D to +/- 2.25 D). The mean AL was 23.1 +/- 1.2 mm (range, 20-27 mm). The mean central CT was 388.2 +/- 50.0 mu m and was not correlated with age, gender, AL, or refractive error. Conclusions: The data provide a pediatric normative database of CT using enhanced depth imaging OCT. This information may be useful in the diagnosis and monitoring of retino-choroidal diseases in children.Öğe Comparison of anterior chamber depth measurements of Nidek AL-Scan and Galilei Dual Scheimpflug Analyzer(Elsevier Science Bv, 2015) Dervisogullari, Mehmet Serdar; Totan, Yuksel; Guragac, BetulPurpose: We aimed to compare anterior chamber depth (ACD) measurements between the Nidek AL-Scan and the Galilei Dual Scheimpflug Analyzer. Setting: Turgut Ozal University Medical Faculty, Ankara, Turkey. Design: Prospective masked bilateral randomized study. Methods: Sixty-three individual patient eyes with normal ocular examination findings and no prior ocular surgery were analyzed. Paired two-tailed t-test was used to evaluate agreement between devices. Interobserver repeatability was evaluated in 22 patients using intraclass correlation coefficient (ICC) and Bland-Altman analysis. Results: The mean +/- standard deviation (+/- SD) ACD for Nidek and Galilei was 3.57 +/- 0.29 (range from 2.92 to 4.32) and 3.65 +/- 0.29 (range from 3.01 to 4.40), respectively. Comparing the two instruments using paired samples t-test, a statistically significant difference was found between the measurements obtained for ACD (P = 0). Two observers' intraclass correlation coefficients (ICC) were 0.996 for Nidek and 0.968 for Galilei. For Nidek, ACD mean difference was 0 mm (P < 0.001); 95% limits of agreement was from -0.05 to 0.05. For Galilei ACD mean difference was -0.01 mm (P < 0.001); 95% limits of agreement was from -0.14 to 0.12. The Galilei Dual Scheimpflug Analyzer measured longer ACD values than the Nidek AL-Scan. Conclusion: This comparative study showed that the difference in ACD between the measurements of the Nidek AL-Scan and the Galilei Dual Scheimpflug Analyzer was statistically significant but clinically it was negligible. Further studies are needed, especially on IOL calculation formulas that include ACD and its effect on postoperative spherical equivalent values. C) 2014 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.Öğe Effect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform layer complex(Taylor & Francis Ltd, 2015) Dervisogullari, Mehmet Serdar; Totan, Yuksel; Tenlik, Aylin; Yuce, Aslihan; Guler, EmrePurpose: The aim of this study is to show the effects of smoking on retina layers, especially retina nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer complex (GCIPL). Materials and methods: Participants smoking for more than 10 years at least 1 pack of cigarettes a day and a control group, both including participants between ages of 20 and 50 years with no other systemic or ocular diseases were studied. After normality tests, an independent sample t test was used to analyze the differences in age, sex, spherical equivalent (SE), intraocular pressure (IOP), axial length (AL), GCIPL and RNFL values between the groups. Results: There were 44 participants in each group. There were 32 (62.5%) men and 12(37.5%) women in smokers and 36 (77.88%) men and 8 (22.22%) women in control group. Mean ages were 39.85 +/- 8.41 and 38.66 +/- 10.47 years, mean spherical equivalent (SE) values were +/- 0.15 +/- 0.4 and 0 +/- 0.29 dioptries in smokers and control groups, respectively. The IOP, AXL, GCIPL and RNFL values were 17.58 +/- 3.41 mmHg, 23.69 +/- 0.56 mm, 84.3 +/- 5.83 mu m and 92.3 +/- 3.51 mu m in the smokers group and 18.5 +/- 2.91 mmHg, 23.45 +/- 0.72 mm, 86.11 +/- 8.02 mu m and 97.66 +/- 8.23 mu m in the control group. The inferior, superior, nasal and temporal values of RNFL quadrants were 123.18 +/- 26.14, 117.05 +/- 5.51, 64.95 +/- 8.67 and 63.5 +/- 6.88 mu m in the smokers group and 130.81 +/- 11.8, 123.55 +/- 11.03, 72.44 +/- 9.84 and 58.44 +/- 7.48 mu m in the control group. There were no significant difference of age, sex, SE, IOP, AXL and GCIPL values between the smokers and control groups (p>0.05). The mean RNFL was significantly thinner in the smokers group compared to controls (p = 0.03, independent t test). Inferior and superior quadrants of RNFL decreased in smokers group (p = 0.01 and p = 0.03, respectively) but temporal and nasal quadrants did not seem to be changed (p = 0.96 and p = 0.07, respectively). Discussion: Smoking may affect RNFL thickness but not GCIPL.Öğe Evaluation of Choroidal Thickness in Amblyopia Using Enhanced Depth Imaging Optical Coherence Tomography(Taylor & Francis Inc, 2015) Tenlik, Aylin; Guler, Emre; Kulak, Ali Ender; Totan, Yuksel; Dervisogullari, Mehmet Serdar; Guragac, Fatma BetulPurpose: To evaluate the choroidal thickness (CT) in hyperopic anisometropic amblyopic eyes, fellow non-amblyopic eyes, and age-matched normal eyes, using spectral-domain optical coherence tomography (SD-OCT). Materials and methods: In total 53 subjects (17.8 +/- 11.0 years, mean +/- SD) with hyperopic anisometropic amblyopia (AE) and 53 age-matched controls (17.7 +/- 11.0 years) were included in this prospective study. Each subject underwent a dilated eye examination, cycloplegic refraction and axial length (AL) measurement using Nidek AL-Scan optical biometer (Nidek CO, Aichi, Japan). The CT of subfoveal area and at a radius of 1 and 3mm around the fovea was determined using the enhanced depth imaging program of a SD-OCT (Cirrus HD OCT, Carl-Zeiss Meditec, Dublin, CA). CT, AL and spherical equivalent refraction (SER) of the amblyopic eyes were compared to that of the fellow and control eyes. Results: The mean subfoveal CTwas 305.6 +/- 26.0 mm in the amblyopic eyes, 282.6 +/- 30.7 mm in the fellow eyes and 280.1 +/- 8.8 in the control eyes. The subfoveal choroid in amblyopic eyes was significantly thicker than that of the fellow eyes and control eyes (p<0.001). There was a significant negative correlation between the subfoveal CT and the AL in amblyopic (r=-0.298, p=0.03) eyes but not in the control and fellow eyes. Conclusions: The subfoveal choroid of eyes with hyperopic AE is significantly thicker than that of the fellow eye and the age-matched controls. Hence, CT seems to be effected in AE.Öğe The Efficacy and Safety of Valproic Acid in the Treatment of Retinitis Pigmentosa(Karger, 2014) Totan, Yuksel; Guler, Emre; Yuce, Aslihan; Dervisogullari, Mehmet Serdar[Abstract Not Available]
