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Öğe 46, XX Sry(+) Male Sexual Differentiation Disorder with Metabolic Syndrome: A Case Report(Galenos Yayincilik, 2014) Cosar, Ramazan; Demirci, Huseyin; Kocakap, Derya Beyza Sayin; Ciftci, Ozcan; Kavak, Engin ErenIn disorders of sexual differentiation, sexual development may not be in accordance with chromosomal structure. 46, XX male syndrome is one of these kind of situations of which most of the patients are in normal male phenotype at birth. These patients are diagnosed while investigating for gynecomastia during puberty or infertility at older ages. One of the comorbidities of testosterone deficiency is metabolic syndrome. Recent studies have demonstrated a strong relationship between hypogonadism and metabolic syndrome. A 42-year-old male patient was admitted to our outpatient clinic with the complaint of gynecomastia. Based on laboratory tests results, he was diagnosed with hypergonadotropic hypogonadism accompanied by metabolic syndrome. Chromosomal analysis showed 46, XX SRY (+) genotype.Öğe A Rare Case Report: Cavernous Hemangioma of the Thyroid(Gazi Univ, Fac Med, 2014) Keren, Fatma; Demirci, Huseyin; Ceydilek, Bilge; Arslan, NurHemangiomas are benign tumoral formations which can be seen in many organs. Although it is rare at thyroid tissue, often it consists of after thyroid fine-needle biopsy. These cases can not be diagnosed with imaging methods. Its final diagnosis is histopathological. Here, we will present a case report. The patient was followed due to multinodular goitre and had a total thyroidectomy operation with suspicion of malignancy after thyroid fine-needle biopsy . After the operation she was diagnosed to have cavernous hemangioma of the thyroid. In the literature, a few cases which were operated with suspected malignancy have been reported as cavernous hemangioma of the thyroid. The available information shows that; while approaching to thyroid nodules, cavernous hemangioma of the thyroid should be considered and must be made differential diagnosis with malignancy.Öğe Atypical Diabetic Ketoacidosis: Case Report(Galenos Publ House, 2015) Demirci, Huseyin; Cosar, Ramazan; Ciftci, Ozcan; Sari, Isilay KalanBackground: Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus and can lead to death if untreated. It is a complex metabolic state characterised by hyperglycaemia, acidosis and ketonuria. Bonsai is one of the herbal incense products that contains synthetic cannabinoid and can be easily accessible via the internet in many countries. It cannot be detected in blood and urine studies using conventional methods. Synthetic cannabinoid abuse is associated with severe side effects, including tachycardia, high blood pressure, acidosis, excess sedation and coma. Case Report: A 17-year-old male patient was brought to the emergency department with sudden onset of dyspnoea. Laboratory investigations revealed hyperglycaemia, acidosis and ketonuria. He was admitted to the intensive care unit with a diagnosis of diabetic ketoacidosis. He was not considered a typical case of diabetic ketoacidosis because of the tendency to hypokalaemia, persistent tachycardia and bronchoscopic findings. We learned from his friends that he had used cannabis for a week and used bonzai on the day that he was brought to the emergency service. Conclusion: Diabetic ketoacidosis with prolonged acidosis and tendency to hypokalaemia are investigated for the consumption of synthetic cannabinoids.Öğe Pregnancy with Congenital Adrenal Hyperplasia: A Case Report(Gazi Univ, Fac Med, 2015) Akdeniz, Derya; Demirci, Huseyin; Ceydilek, Bilge; Yavuz, Halise CinarCongenital adrenal hyperplasia is a group of autosomal recessive disorders characterized by impaired cortisol synthesis. Dysregulation of corticotropin synthesis often leads to increased synthesis of adrenal androgens. Low fertility is often and troublesome condition in patients with congenital adrenal hyperplasia. In this report, we presented a case report which is a woman with non-classical hyperplasia who were pregnant and followed until delivery in our clinic.Öğe The Relationship between Serum Homocysteine Levels and Nonproliferative Diabetic Retinopathy in Type 2 Diabetes Mellitus(Gazi Univ, Fac Med, 2015) Demirci, Huseyin; Onaran, Zafer; Gokcmar, Nesrin; Erdamar, Husamettin; Ornek, NurgulObjective: To evaluate the relationship between serum homocysteine levels and the presence of nonproliferative diabetic retinopathy (NPDR) in type 2 Diabetes Mellitus (T2DM) patients Methods: One-hundred patients with a diagnosis of T2DM and 30 healthy control subjects whose age and sex were similar were included in this study. In diabetic patients retinopathy was assessed by ophthalmological examination. Homocysteine, fasting glucose, HbA1C, triglyceride, total cholesterol, high density lipoprotein and low density lipoprotein levels were analyzed in the blood samples in both groups. Also microalbumin levels were analyzed in 24-hour urine samples. T2DM patients were further divided into two groups according to the presence of retinopathy as patients with NPDR (Group 1, n=32) and without retinopathy (Group 2, n=68). Results: There was no statistically significant difference in the homocysteine levels between the T2DM group and the control group (13.13 +/- 4.35 mu mol/l and 12.29 +/- 4.81 mu mol/l, respectively, p>0.05). Although homocysteine levels were higher in the patients with diabetic retinopathy (Group 1) than the diabetic patients without any diabetic complication (Group 2), the difference was not statistically significant (13.21 +/- 4.23mmol/l and 12.96 +/- 4.60mmol/l, respectively, p>0.05). Conclusion: There was no increase in serum homocysteine levels in T2DM when there was no additional diabetic or cardiovascular complication other than NPDR. Our study, by demonstrating that serum homocysteine level was irrelevant to the presence of NPDR, suggests that homocysteine does not play a role at the early stages of retinopathy.
