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    Anesthesia Management of Pediatric Burn Patients: A Retrospective Analysis of Patients Treated in a University Hospital
    (2025) KARAASLAN, EROL; Yalin, Mehmet Ridvan; Ozkan, Ahmet Selim; Begec, Zekine; Demircan, Mehmet
    Introduction: This retrospective study focused on pediatric patients who underwent surgery for burns under anesthesia in our hospital and assessed demographic data, anesthesia management, and risk factors for mortality. The study comprised 278 pediatric patients who were treated in our unit, a major center for burn admissions, between January 2012 and May 2021. All the patients had burns involving more than 10% of the total body surface area. Methods: Data on the following were collected: patient age, sex, and ethnicity; anesthesia and airway management- and surgery- related procedures; and laboratory test results. The data on the fatal and non-fatal cases and those with/without head and neck burns were compared. Results: The mean age of the patients was 56.8±42.9 months (range 1-204 months). The number of patients with flame burns was statistically, significantly higher than the number of patients with liquid and electrical burns (54.7%, 37.1%, and 8.3%, respectively) (p<0.001). Albumin (p=0.046), platelet (p=0.005), and calcium (p=0.001) values were significantly lower, and blood urea nitrogen (p=0.024) and C-reactive protein (p=0.001) values were significantly higher in mortality cases than in non-mortality cases. Patients who died were statistically significantly younger (p=0.023). For airway management, endotracheal intubation and sugammadex were used significantly more often for head and neck burns than for other types of burns (p<0.001). Conclusion: Appropriate preoperative preparation, including consideration of the anesthetic method and potential complications that may develop during the surgery, is needed in pediatric burn cases. Anesthesia and airway management are important in managing pediatric burn patients.
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    Impaction of the polylactic membrane or hydrofiber with silver dressings on the interleukin-6, tumor necrosis factor-α, transforming growth factor-b3 levels in the blood and tissues of pediatric patients with burns
    (11.12.2020) Demircan, Mehmet; Gürünlüoğlu, Kubilay; Gözükara Bağ, Harika Gözde; Koçbıyık, Alper; Gül, Mehmet; Üremiş, Nuray; Gül, Semir; Türköz, Yusuf; Taşcı, Aytaç; Gürünlüoğlu, Semra
    BACKGROUND: We aimed to evaluate the effects of two different burn dressings, hydrofiber with a silver (HFAg) and polylactic membrane (PLM), on altering the levels of important biomarkers Interleukin-6 (IL-6), Tumor necrosis factor-? (TNF-?), Transforming growth factor-?3 (TGF-?3 ) in blood and burnt tissue in children with second-degree burns. METHODS: Children between the ages of one to 16 years, with 25–50% second-degree partial-thickness burns of the total body surface area were included in this study. Patients in the PLM group were dressed with PLM in a typical way according to the manual. The HFAg group was dressed with HFAg and a sterile cover. During and at the end of the 21-day treatment, blood and skin tissue samples were taken from the two burn and control groups. IL-6, TNF-?, and TGF-? ?3 levels were evaluated in blood and tissue samples from all groups, and the results were analyzed statistically. RESULTS: In the PLM group, IL-6 and TNF-? levels decreased early days in both serum and tissue samples to reach normal ranges compared with the HFAg group. In the PLM group, TGF-?3 levels were elevated than in other groups for two weeks. CONCLUSION: In this study, we found that PLM controls inflammation earlier in both systemic and burn tissue. We also found that PLM increased the level of TGF-?3 , which may be associated with the prevention of the development of hypertrophic scar in the burn wound, in the blood and burn tissue during this study