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    Higher levels of circulating chemerin in both lean and obese patients with polycystic ovary syndrome
    (Edizioni Minerva Medica subscriptions.dept@minervamedica.it, 2014) Ademoğlu, Esranur; Berberoglu, Suha; Çarlioğlu, Ayşe Kargılı; Dellal, Fatma Dilek; Görar, Süheyla; Alphan, Ziynet; Uysal, Sema
    The aim of this paper was to compare serum chemerin levels in nonobese and overweight/obese patients with polycystic ovary syndrome (PCOS) with lean controls. Methods. Seventy women with newly diagnosed or untreated PCOS and 38 age-matched nonobese healthy controls were enrolled in the present study. Participants with PCOS were categorized as nonobese (Body Mass Index [BMI] <25 kg/m2, N.=36) or overweight/obese (BMI 25-29.9 kg/m2 and ?30 kg/m2, respectively, N.=34). Anthropometric, metabolic and hormonal patterns, and serum chemerin were measured. Results. Serum chemerin tended to be higher in obese PCOS group than in nonobese PCOS women but did not reach statistical significance. Nonobese healthy controls had significantly lower chemerin levels than two PCOS groups (PcO.OOl). Fasting insulin (P<0.05) and homeostasis model assessment index (p<0.05) were significantly higher in obese women with PCOS than in other two groups. Also, these two parameters were higher in lean patients with PCOS than in healthy controls (p<0.05). In multiple linear regression analyses, chemerin was significantly associated with BMI (?-coefficient =0.336, p<0.01), and triglyceride (?-coefficient =0.298, p<0.05). Conclusion. Chemerin levels were significantly increased not only in obese PCOS women but also in nonobese PCOS women. The physiological significance of elevated serum chemerin in PCOS remains unclear. © 2016 Elsevier B.V., All rights reserved.
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    Plasma nesfatin-1 levels are increased in patients with polycystic ovary syndrome
    (Springer, 2014) Ademoglu, Esra Nur; Gorar, Suheyla; Carlioglu, Ayse; Yazici, Havva; Dellal, Fatma Dilek; Berberoglu, Zehra; Akdeniz, Derya
    Background Nesfatin-1 is a recently discovered neuropeptide derived from its precursor nucleobindin-2 (NUCB2) and has been implicated in the regulation of feeding and energy metabolism. It is located in the brain and also produced at the periphery and present in the plasma. However, its pathophysiological role in humans remains unknown. Polycystic ovary syndrome (PCOS) is commonly presented with obesity, insulin resistance, hyperandrogenemia and hirsutism. Aim To characterize serum nesfatin-1 levels in PCOS women and determine association of nesfatin-1 with metabolic parameters. Materials and methods It is a cross-sectional study of 55 PCOS and 28 healthy women matched in age, in a university hospital setting. Anthropometric, hormonal, metabolic parameters and nesfatin-1 blood levels were determined. Results Nesfatin-1 levels were significantly higher in PCOS group compared with the controls 371.43 +/- 2.50 versus 275.55 +/- 1.74 pg/mL. Multivariate logistic regression analysis that contains: nesfatin-1, body mass index and homeostasis model assessment index revealed significant correlation of nesfatin-1 with the existence of PCOS (p < 0.05). Conclusions Higher nesfatin-1 levels in PCOS women compared to control group may suggest a possibility that nesfatin-1 may play some role in the PCOS.