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    Investigation of the Levels of Serum Amyloid A, YKL-40, and Pentraxin-3 in Patients with Familial Mediterranean Fever
    (Wiley, 2016) Ciftci, Sefa; Celik, Huseyin Tugrul; Atukeren, Pinar; Ciftci, Nurdan; Deniz, Mustafa Saygin; Yavuz, Yasemin Coskun; Kazanci, Fatmanur Hacievliyagil
    BackgroundFamilial Mediterranean Fever (FMF) is an autosomal recessive form of recurrent episodes of fever and an autoinflammatory disease characterized by inflammation of the serous membranes. The clinical diagnosis is supported by the laboratory findings. This study investigated the relationship of Serum Amyloid A (SAA), YKL-40, and Pentraxin-3 (PTX-3) with the FMF disease. MethodsAbout 50 patients with FMF were enrolled in this study. Patients were divided into three groups according to disease severity score (mild, moderate, and severe). Thirty-seven healthy individuals were included as the control group. Serum SAA, YKL-40, and PTX-3 concentrations were measured using an ELISA kit. ResultsSerum SAA and YKL-40 levels of FMF patients were significantly higher than in the control (P < 0.001). PTX-3 levels were found to be higher in patients even though there was no significant difference (P = 0.113). Whereas the positive predictive value was 71.9% for cut-off point of SAA, the positive predictive value was 83.3% for cut-off point of YKL-40. Whereas a significant correlation was detected in SAA and PTX-3 with YKL-40 (respectively; P = 0.036, P < 0.001), there was no correlation between the PTX-3 with SAA (P = 0.219). ConclusionsYKL-40 can be used together with SAA to support the diagnosis of FMF and to monitor the severity of the disease. In this study, YKL-40 levels were examined for the first time in FMF patients and further studies are necessary using larger patient samples.
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    Response to A new remedial approach to oxidant/antioxidant imbalance-based diseases: Wet-cupping therapy
    (Churchill Livingstone, 2015) Celik, Huseyin T.; Kazanci, Fatmanur Hacievliyagil; Ciftci, Sefa; Erdamar, Husamettin
    [Abstract Not Available]
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    THE EFFECT OF DIFFERENT TURKISH SONG COMPOSITIONS ON THE SYMPATHIC AND IMMUNOBIOCHEMICAL PARAMETERS
    (Nobel Ilac, 2015) Yuksel, Sevda; Kazanci, Fatmanur Hacievliyagil; Ciftci, Sefa; Altan, Merve; Yuksel, Mustafa; Erdamar, Husamettin; Yigitoglu, Ramazan
    Objective: Turkey is a rich country in musical heritage. Studies on the use of music for therapeutic purposes are increasing day by day. The Greek philosophers were convinced that music benefited health and specific recommendations were formulated for using music therapeutically against mental and physical illness. To evaluate the effects of different classical Turkish music styles (Saba, Muhayyer Kurdi, Hijaz, Ussak) on these parameters. Therefore we planned this research to accomplish all of these aims. Material and Method: Venous blood samples were collected before and after music listening and serum levels of serotonin, adrenalin, immunoglobulin A and cortisol were measured. Sixtyone healthy volunteers listened five different kinds of music (popular, rock, arabesque, European classical, classical Turkish music). Results: To compare the same parameters in each volunteer before and after music listening, the Wilcoxon signed-ranks were performed as appropriate. For tests of significance, a p-value of <0.05 was considered to be statistically significant. All parameters were normally distributed. Conclusion: Our Statistical analysis results showed that cortisol level of the people listening Saba style decreased, Immunoglobulin A level decreased for the people who listened popular music and increased for the group listening Nihavent style and adrenaline level increased significantly in all groups except for the people listening Ussak style of music.
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    Wet-cupping removes oxidants and decreases oxidative stress
    (Churchill Livingstone, 2014) Tagil, Suleyman Murat; Celik, Huseyin Tugrul; Ciftci, Sefa; Kazanci, Fatmanur Hacievliyagil; Arslan, Muzeyyen; Erdamar, Nazan; Kesik, Yunus
    Objectives: Wet-cupping therapy is one of the oldest known medical techniques. Although it is widely used in various conditions such as acute \ chronic inflammation, infectious diseases, and immune system disorders, its mechanism of action is not fully known. In this study, we investigated the oxidative status as the first step to elucidate possible mechanisms of action of wet cupping. Material and methods: Wet cupping therapy is implemented to 31 healthy volunteers. Venous blood samples and Wet cupping blood samples were taken concurrently. Serum nitricoxide, malondialdehyde levels and activity of superoxide dismutase and myeloperoxidase were measured spectrophotometrically. Results: Wet cupping blood had higher activity of myeloperoxidase, lower activity of superoxide dismutase, higher levels of malondialdehyde and nitricoxide compared to the venous blood. Conclusion: Wet cupping removes oxidants and decreases oxidative stress. (C) 2014 Elsevier Ltd. All rights reserved.