Yazar "Bozer, Mikdat" seçeneğine göre listele

Listeleniyor 1 - 7 / 7
  • Küçük Resim Yok
    Öğe
    A potential association between the number of CA repeats in the promoter region of the ADAMTS9 gene with lymphatic metastasis of breast cancer
    (Tubitak Scientific & Technological Research Council Turkey, 2013) Bozer, Mikdat; Asik, Fatma; Acar, Muradiye; Haltas, Hacer; Yenidunya, Sibel; Canbal, Metin; Topcu, Vehap
    Aim: We investigated the effect of the number of cytosine-adenine (CA) repeats in the ADAMTS9 promoter region on breast cancer lymphatic metastasis. Materials and methods: Thirty-one postoperative breast cancer patients were selected and examined retrospectively. The patients were classified into 2 groups: metastatic or nonmetastatic. Thirty healthy women were selected as the control group, and their peripheral blood was obtained. Following DNA isolation from the cancer tissue specimens and peripheral blood, the promoter region of the ADAMTS9 gene was directly sequenced and the number of CA repeats was determined. Results: The number of CA repeats ranged between 19 and 21 in the control and metastatic groups. However, in the nonmetastatic group, the number of CA repeats ranged between 17 and 18. This difference in the median number of CA repeats between the control group and the nonmetastatic group was statistically significant. Conclusion: A potential relationship may exist between lymphatic metastasis in breast cancer and the number of CA repeats in the promoter region of the ADAMTS9 gene. Our study indicates a potential association between the number of CA microsatellite repeats in the promoter region of the ADAMTS9 gene and breast cancer lymphatic metastasis.
  • Küçük Resim Yok
    Öğe
    Differentially regulated ADAMTS1, 8, 9, and 18 in pancreas adenocarcinoma
    (Termedia Publishing House Ltd, 2017) Kilic, Murat Ozgur; Aynekin, Busra; Bozer, Mikdat; Kara, Adem; Haltas, Hacer; Icen, Duygu; Demircan, Kadir
    Introduction: Despite recent diagnostic and therapeutic improvements, pancreas cancer remains one of the highly lethal cancers. The extracellular matrix (ECM) is a physiological barrier that limits the spread of cancer cells into surrounding tissues and distant organs. Disintegrin and metalloprotease with thrombospondin motifs (ADAMTS) is a family of 19 proteases, which is involved in various biological processes such as ECM remodelling and anti-angiogenesis. Aim: To investigate the expression of ADAMTS1, 8, 9, and 18 proteinases in pancreas adenocarcinoma and its nodal metastasis. Material and methods: The immunostaining status of ADAMTS1, 8, 9, and 18 were investigated in formalin-fixed paraffin-embedded samples of 25 patients who underwent pancreaticoduodenectomy for an adenocarcinoma located at the head of the pancreas. Results: In semi-quantitive grading pathologically, ADAMTS1, 8, 9, and 18 were found to be highly stained in all cancerous pancreas samples compared with normal pancreas. In addition, the immune positivity of ADAMTS1, 9, and 18 was found to be higher in metastatic lymph nodes than in non-metastatic lymph tissue. Tumour size was correlated with ADAMTS9 and 18 expressions in cancerous pancreas. Conclusions: According to the data obtained from the study, we suggest that these four ADAMTSs may have significant roles in the tumorigenesis and nodal spread of pancreas adenocarcinoma.
  • Küçük Resim Yok
    Öğe
    Four mucinous cystadenoma of the appendix treated by different approaches
    (Aves, 2014) Kilic, Murat Ozgr; Inan, Aydin; Bozer, Mikdat
    Appendiceal mucocele is a rare clinical entity characterized by dilatation of the appendiceal lumen due to abnormal mucinous secretion. It may be of inflammatory or tumoral origin. It may occur as a result of mucoceles, mucosal hyperplasia, mucinous cystadenoma or mucinous cystadenocarcinoma. Mucinous cystadenoma of the appendix is the most common form, although it manifests itself in many different clinical presentations. It is detected in 0.6% of appendectomy specimens. Preoperative diagnosis is difficult, and it is often detected at laparotomy. Despite existing reservations due to the risk of rupture, laparoscopic surgery is gaining acceptance. Although there is no consensus on the choice of surgery, either appendectomy or right hemicolectomy is applied. In this article, we discussed four patients with appendix mucinous cystadenoma where different surgical methods were applied in light of the literature.
  • Küçük Resim Yok
    Öğe
    Gastrointestinal stromal Tumor with mesenteric Localization Fistulized to Proximal Jejunum Causing Massive Rectal Bleeding
    (Derman Medical Publ, 2016) Kafadar, Mehmet Tolga; Nadir, Isilay; Bozer, Mikdat
    Gastrointestinal stromal tumors (CISTs) are the most common mesenchymal tumors of the gastrointestinal system. These non-epithelial tumors originate from the muscularispropria layer of the wall of the gastrointestinal tract Their most common locations of origin are the stomach and small intestine Rarely, they may originate from the retroperitoneum or abdomen. and may have no connection with the gastrointestinal system. They are usually incidentally detected in endoscopic and radiological examinations of the gastrointestinal system or during surgical treatment of emergency conditions such as hemorrhage, obstruction, or organ perforation. In this paper, we report a 59-year-old man with GIST located in the proximal jejunum that caused massive bleeding owing to its rarely encountered location. Histopathological examination made the definitive diagnosis, and the patient underwent total excision of the Pass and the resection of a 20-cm jejunal segment.
  • Küçük Resim Yok
    Öğe
    Loss of heterozygosity in ING3 and ING5 genes in breast cancer
    (Tubitak Scientific & Technological Research Council Turkey, 2014) Gunduz, Esra; Nas, Gokhan; Acar, Muradiye; Uctepe, Eyyup; Bozer, Mikdat; Oznur, Murat; Bayrak, Reyhan
    The tumor suppressor genes (TSGs) ING3 and ING5, members of the inhibitor of growth gene family, are effective in inhibition of cell growth and induction of apoptosis. However, in many cancer types, one of the alleles of a TSG is lost through carcinogenesis, while the remaining allele is usually inactivated through a process called loss of heterozygosity (LOH). Previous studies in head and neck cancer revealed that allelic loss and reduced expression is a common pattern of ING gene family members. Fifty paraffin-embedded breast cancer tissues were analyzed by polymerase chain reaction and denatured-polyacrylamide gel electrophoresis for LOH status. The allelic deletion frequency of ING3 and ING5 were detected as 14% and 17% in breast cancer patients, respectively. No significant relationship was detected between ING3 LOH status and clinicopathological variables. Our data also suggest that both ING3 and ING5 LOH statuses have no significant effect in overall survival and disease-free survival of breast cancer patients. These results provide a rational explanation and relative contribution for the complexity of tumor formation, whereby allelic loss of ING3 and ING5 genes is not a major factor for breast cancer but is rather a part of a larger complex mechanism.
  • Küçük Resim Yok
    Öğe
    Male Breast Cancer
    (Aves, 2016) Yalaza, Metin; Inan, Aydin; Bozer, Mikdat
    Male breast cancer (MBC) is a rare disease, accounting for less than 1% of all breast cancer diagnoses worldwide. Although breast carcinomas share certain characteristics in both genders, there are notable differences. Most studies on men with breast cancer are very small. Thus, most data on male breast cancer are derived from studies on females. However, when a number of these small studies are grouped together, we can learn more from them. This review emphasizes the incidence, etiology, clinical features, diagnosis, treatment, pathology, survival, and prognostic factors related to MBC.
  • Küçük Resim Yok
    Öğe
    Non-Operative Management of Isolated Pneumoperitoneum Due to Severe Blunt Abdominal Trauma
    (Derman Medical Publ, 2015) Kilic, Murat Ozgur; Bozer, Mikdat; Turkan, Ahmet; Kilic, Yeliz
    Nonperative management of blunt abdominal trauma is the treatment of choice for hemodynamically stable patients. The results of nonoperative management are more successful in isolated solid organ injuries such as the liver and spleen than hollow viscus injury. In this approach, both the clinical course of the patient and the computed tomography findings play an important role. Isolated pneumoperitoneum in blunt abdominal trauma may be a surgical challenge for clinicians because it is usually a significant radiological sign for hallow viscus perforations. Here, we report a case of isolated pneumoperitoneum detected on computed tomography and managed non-surgically, in a young man suffered from a severe blunt abdominal trauma. Our aim is to attract the attention of surgeons to the management problems of the presence of pneumoperitoneum in the absence of other radiological findings in blunt abdominal trauma.