Yazar "Bilgic, M. A." seçeneğine göre listele

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    Ca 125 Levels and LV Function in Patients with ESRD Treated with Maintenance Hemodialysis Patients
    (Excerpta Medica Inc-Elsevier Science Inc, 2014) Yilmaz, H.; Bilgic, M. A.; Gurel, O. Malcok; Sahiner, E.; Celik, H. T.; Bavbek, N.; Akcay, A.
    [Abstract Not Available]
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    Can Galectin-3 Be A New Biomarker to Detect Diastolic Dysfunction in HD Patients?
    (Excerpta Medica Inc-Elsevier Science Inc, 2014) Gurel, O. Malcok; Yilmaz, H.; Celik, H. T.; Namuslu, M.; Bilgic, M. A.; Bavbek, N.; Akcay, A.
    [Abstract Not Available]
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    Increased Serum Levels Of GDF-15 are Associated with Cardiovascular Death, Subclinic Atherosclerosis in Patients on Maintenance Hemodialysis
    (Excerpta Medica Inc-Elsevier Science Inc, 2014) Yilmaz, H.; Celik, H. T.; Gurel, O. M.; Bilgic, M. A.; Namuslu, M.; Bozkurt, H.; Ayyildiz, A.
    [Abstract Not Available]
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    Increased serum levels of GDF-15 associated with mortality and subclinical atherosclerosis in patients on maintenance hemodialysis
    (Urban & Vogel, 2015) Yilmaz, H.; Celik, H. T.; Gurel, O. M.; Bilgic, M. A.; Namuslu, M.; Bozkurt, H.; Ayyildiz, A.
    Background/aims. Increased carotid intima-media thickness (CIMT) was shown to be an independent predictor of cardiovascular (CV) mortality in dialysis patients and the general population. Growth differentiation factor 15 (GDF-15), a member of the transforming growth factor superfamily, is produced by cardiomyocytes and atherosclerotic lesions under stress conditions such as inflammation. We assessed associations between serum concentrations of GDF-15, mortality, and CIMT for subclinical atherosclerosis in hemodialysis (HD) patients. Methods. A total of 87 patients on maintenance hemodialysis and 45 sex-and age-matched healthy controls were included in this prospective study. Serum GDF-15 levels were measured by ELISA. CIMT was assessed by Doppler ultrasonography. The association between serum GDF-15 levels and mortality was assessed using Cox regression analysis with serum levels categorized into two groups according to the median value (328.18 pg/ml). Patients were followed for 2 years and cause-specific and all-cause mortality were determined. Results. The median level of serum GDF-15 was significantly higher in HD patients than controls [ 328 (198-522) vs. 176 (101-289) pg/ml, p<0.01, respectively]. Serum GDF-15 levels were correlated to CIMT (r=0.607, p<0.001), C-reactive protein (CRP; r=0.250, p=0.010), HD duration (r=0.376, p=0.004), and serum albumin (r=-0.156, p=0.030). The multivariate analysis revealed that GDF-15 was found to be an independent variable of CIMT in HD patients. In the study, the serum GDF-15 level was an independent marker of all-cause of mortality when adjusted for age, CRP, and history of diabetes mellitus. Conclusion. The relationship between serum GDF-15, mortality, and carotid artery thickening suggests that GDF-15 may be a novel marker of atherosclerosis, inflammation, and malnutrition in HD patients.
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    Relationship of galectin-3 to left ventricular geometry and hypertrophy in chronic hemodialysis patients
    (Urban & Vogel, 2015) Yilmaz, H.; Gurel, O. M.; Celik, H. T.; Bozkurt, A.; Yildirim, M. E.; Bilgic, I.; Bilgic, M. A.
    Aim and background. Galectin-3 (Gal-3) is used to determine the prognosis of heart failure. Some studies revealed that Gal-3 promoted cardiac hypertrophy but there is no study in which the relationship between -Gal-3 and left ventricular hypertrophy (LVH) geometry in patients without diastolic and systolic function impairment has been explored. The aim of the study was to analyze associations between plasma Gal-3 levels, LVH, and LV geometry in maintenance hemodialysis (HD) patients without systolic and diastolic dysfunction. Patients and methods. The study group included 105 patients (53 women and 52 men)-with an average age of 58.2+/-12.6 years, treated with HD for an average of 45+/-32 months-and 60 healthy controls. The Gal-3 and other biochemical parameters were measured and color Doppler echocardiography was performed. For this study LVH was considered present when the LV mass index (LVMI) exceeded 95 g/m(2) in women and 115 g/m(2) in men. Left ventricular geometry was classified into the four groups on the basis of left ventricular mass and relative wall thickness (RWT). Results. Concentric hypertrophy (CH, 40.9%, n= 43) was the commonest geometric pattern in our study. The Gal-3 levels in CH patients were not different from the patients with eccentric hypertrophy (EH). Plasma levels of Gal-3 correlated with LVMI (r= 0.617, p< 0.001), parathyroid hormone (PTH, r= 0.408, p< 0.001), uric acid (r= 0.281, p = 0.004), C-reactive protein (CRP, r= 0.412, p< 0.001), and RWT (r= 0.281, p = 0.004) but were inversely correlated with albumin (r=-0.466, P< 0.001) in the whole group. Plasma levels of Gal-3 were associated with LVMI (r= 0.812, P< 0.001), RWT (r= 0.318, p = 0.001), and CRP(r= 0.381, p< 0.001) in maintenance hemodialysis patients. Conclusion. The Gal-3 level is related to left ventricular hypertrophy and it is independent of left ventricle geometry. The relationship between LVH and Gal-3 might be direct or it may also be inflammation-related.