Yazar "Bay Karabulut, Aysun" seçeneğine göre listele

Listeleniyor 1 - 13 / 13
  • Küçük Resim
    Öğe
    Biochemical effect evaluation of microbial chondroitin sulphate in experimental knee osteoarthritis model
    (Erenler, Ayse Sebnem; Karabulut, Aysun Bay; Otlu, Onder, 2022) Erenler, Ayse Şebnem; Bay Karabulut, Aysun; Sevimli, Resit; Geçkil, Hikmet; Akpolat, Nusret; Ünver, Tuba; Otlu, Önder
    Osteoarthritis (OA) is the most commonchronic joint disease, primarily due to aging.Chondroitin sulfate (CS) is a glycosaminoglycan(GAG) commonly used to treat osteoarthritis. CS candelay the progression of pathology or reversemorphological changes in joint structure.Traditionally CS is produced from animal sources.However, due to different reasons such ascontamination, ecological risA, and the possibility ofinfectious diseases, the trend towards microbialsources has increased because of its advantages suchas purer, more antiallergic, and lower MolecularWeight (MW) than animal sources. Biochemicalanalysis of Microbial CS (MCS), which is a new andsignificant alternative as a source of CS in the OAhealing process, has not been evaluated in theliterature yet. This study was designed to analyze thebiochemical effects of MCS produced by our teamfrom a microbial source, with an MW value of 269Daltons, on the osteoarthritis healing processcompared to the commercial form. We aim to reachdata that MCS has a higher antioxidant effect thananimalYsourced CS, and in this way, it is a moresuitable production for the treatment ofosteoarthritis. In this study, Anee osteoarthritis wassurgically induced in experimental rabbits; and TGFY1?, CAT, MPO, TOS, and OSI parameters measuredin blood samples before the operation and after thehealing period were analyzed comparatively. Afterthe surgical application, the rabbits were randomlydivided into three groups: control, animalYsourcedCS, and E. coli sourced MCS. The standard rabbitdiet was administered daily to 10 rabbits in Group 1(control), and CS and MCS were applied daily to theother groups as 17 mg/Ag for 12 weeAs. Bloodsamples were taAen from rabbits at the 12th weeAafter surgery, and TGFY1?, CAT, MPO, TOS, andOSI parameters were biochemically evaluated. Thisstudy has confirmed that the antioxidant propertiesof MCS and data on its effectiveness in controllingoxidative stress compared to animalYsourced CS.Based on these results, it can be concluded that MCShas a significant potency of nutraceutical andtherapeutic agents for OA treatment.
  • Küçük Resim
    Öğe
    Çocuklarda çürük dişlerin bir renkli kompomer ile restore edilmesinden sonra tükürükteki oksidatif stres ve antioksidan seviyelerde meydana gelen değişikliklerin değerlendirilmesi
    (2020-09-19) Güler, Çiğdem; Bay Karabulut, Aysun; Görgen, Veli Alper; Güneş, Dilek
    Amaç: Bu çalışmanın amacı, çocuklarda çürük dişlerin bir renkli kompomer ile restore edilmesinden sonra tükürükteki oksidatif stres ve antioksidan seviyelerde meydana gelen değişikliklerin değerlendirilmesidir. Gereç ve Yöntem: Çalışma yaşları 8-12 yıl (ortalama 8,9±1,3 yıl) arasında değişen 40 çocuk (20 erkek, 20 kız) üzerinde yürütülmüştür. Çalışmada kontrol grupları (çürüksüz kız ve çürüksüz erkek) ve çalışma grupları (çürüklü kız ve çürüklü erkek) oluşturulmuştur (n=10). Çürük dişler bir renkli kompomer materyali ile restore edilmiştir. Restorasyonların değerlendirilmesinde Modifiye Ryge kriterleri (USPHS kriterleri) kullanılmıştır. Tükürük total antioksidan seviyesi (TAS), total oksidan seviyesi (TOS) ve 8-Hidroksi-2’-deoksiguanizin seviyesi (8- OHdG) üç farklı zamanda [tedavi öncesi (T1), tedavi sonrası 1 ay (T2) ve 3 ay (T3)] değerlendirilmiştir. Tüm veriler istatistiksel olarak analiz edilmiştir. Bulgular: Tüm renkli kompomerler 1 ve 3 ay kontrollerinde USPHS kriterleri açısından Alpha skoru sergilemiştir. Kontrol gruplarında tükürük TOS, TAS ve 8-OHdG değerleri erkeklerde kızlardan daha yüksek bulunsa bile, farklılık istatistiksel olarak anlamsız bulunmuştur (p>0,05). Çürük varlığında tüm parametrelerde artış tespit edilmiştir. Çalışma gruplarında tükürük TOS, TAS ve 8-OHdG değerlerinde meydana gelen değişim istatistiksel olarak anlamlı bulunmuştur (p<0,05). Sonuç: Tükürük TOS, TAS ve 8-OHdG değerleri çürük varlığında artmıştır. Çürük dişlerin renkli kompomer ile restorasyonundan sonra bile parametreler yüksek bulunmuştur.
  • Küçük Resim
    Öğe
    Complications related to COVID-19 infection in neurological diseases
    (CMJ, 15 aralık 2021) Kıran,Tuğba Raika; Bay Karabulut, Aysun; Bolayır, Aslı
    Neurological signs and symptoms constitute at least 35% of the findings reported from the beginning of the coronavirus-19 (COVID-19) epidemic until now. Neurological symptoms based on myopathy,headache,taste and smell disorders,dizziness, impaired consciousness, encephalitis, and peripheral nervous system disorders such as Guillain-Barré and Miller Fisher syndromes, have been described. We aimed to provide information on how COVID-19 infection affects neurological system and possible damage mechanisms.This review has been prepared by scanning severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19, coronavirus, neurological symptoms, results, pandemic keyword combinations in the database. In the literature review, a total of 57 articles, including case series, case report, letter, article and review, were reached on the neurological disorders associated with COVID-19 in the last two years.If the patient is older, the COVID-19 infection may be more severe. Hypertension, obesity, diabetes, and cardiovascular diseases also make more challenging the clinical cases. In addition, patients with a history of neurological disorders and acute respiratory symptoms appear to be at higher risk of encephalopathy
  • Küçük Resim
    Öğe
    Effect of Altered Iron Metabolism on Hyperinflammation and Coagulopathy in Patients with Critical COVID-19: A Retrospective Study
    (JAMP, 15.01.2022) Kıran,Tuğba Raika; Otlu, Önder; Erdem, Mehmet; Korkmaz, Kübranur; Ota Günay, Özge; İn, Erdal; Bay Karabulut, Aysun
    Abstract: A novel coronavirus disease 2019 (COVID-19) outbreak has started in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The relationship between altered iron homeostasis and hyperinflammation may be hallmarks of COVID-19 disease. We aimed to compare some iron (ferritin and iron), inflammation (C-reactive protein [CRP], hemoglobin, lactate dehydrogenase [LDH], neutrophil) and coagulation (prothrombin time [PT], activated partial thromboplastin time [APTT], D-dimer, platelet) marker results of critical COVID-19 patients with healthy controls results. In this single center retrospective study, 50 critical patients diagnosed with COVID-19 were included, demographic, clinical characteristics, severity of disease and laboratory test results were elicited from electronic medical records and compared to 50 healthy people. A statistically significant increase in CRP, LDH, neutrophil, PT, APTT, D-dimer ferritin levels was observed in critical COVID-19 patients compared with healthy people while a statistically significant decrease was observed in hemoglobin and iron levels. In addition, no statistically significant change in platelet levels was observed. Ferroptosis may be a significant cause of multiple organ failure in critical COVID-19 patients. Ferroptosis inhibitors might have potential to combat ferroptosis in COVID-19. Therefore, larger studies are needed to ferroptosis in COVID-19 in vivo and in vitro.
  • Küçük Resim
    Öğe
    Effect of Altered Iron Metabolism on Hyperinflammation and Coagulopathy in Patients with Critical COVID-19: A Retrospective Study
    (2022) Otlu, Önder; Erdem, Mehmet; Korkmaz, Kübranur; Günay, Özge Ota; İn, Erdal; Kıran, Tuğba Raika; Bay Karabulut, Aysun
    Abstract: A novel coronavirus disease 2019 (COVID-19) outbreak has started in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The relationship between altered iron homeostasis and hyperinflammation may be hallmarks of COVID-19 disease. We aimed to compare some iron (ferritin and iron), inflammation (C-reactive protein [CRP], hemoglobin, lactate dehydrogenase [LDH], neutrophil) and coagulation (prothrombin time [PT], activated partial thromboplastin time [APTT], D-dimer, platelet) marker results of critical COVID-19 patients with healthy controls results. In this single center retrospective study, 50 critical patients diagnosed with COVID-19 were included, demographic, clinical characteristics, severity of disease and laboratory test results were elicited from electronic medical records and compared to 50 healthy people. A statistically significant increase in CRP, LDH, neutrophil, PT, APTT, D-dimer ferritin levels was observed in critical COVID-19 patients compared with healthy people while a statistically significant decrease was observed in hemoglobin and iron levels. In addition, no statistically significant change in platelet levels was observed. Ferroptosis may be a significant cause of multiple organ failure in critical COVID-19 patients. Ferroptosis inhibitors might have potential to combat ferroptosis in COVID-19. Therefore, larger studies are needed to ferroptosis in COVID-19 in vivo and in vitro.
  • Küçük Resim
    Öğe
    Koranavirüs Hastalığının Önlenmesi ve Tedavisi İçin Şifalı Bitkiler
    (2021) Otlu, Önder; Bereketoğlu, Ceyhun; Kıran, Tuğba Raika; Bay Karabulut, Aysun
    2019-nCoV (yeni Korona Virüsü) salgını Uluslararası Acil Halk Sağlığı Kuruluşu olan Dünya Sağlık Örgütü (WHO) tarafından 30 Ocak 2020'de ilan edildi ve DSÖ 12 Şubat'ta, 2019-nCoV patojenini SARS-CoV-2 ve Corona virüs Hastalığı 2019 (COVID-2019) olarak adlandırdı. COVID-19 11 Mart 2020’de resmi olarak WHO tarafından Pandemi olarak kabul edildi. Bitkiler tüm dünyada, viral hastalıklar da dahil olmak üzere birçok kronik enfeksiyonu tedavi etmek için yüzyıllardır geleneksel ilaç olarak kullanılmaktadır. Son yıllarda, bilim adamları fonksiyonel ve nutrasötik gıdalar üzerinde yaptıkları araştırmalarla fonksiyonel bileşiklerin insan sağlığını koruma ve hastalıkları iyileştirme potansiyelini doğrulamaya çalışmaktadırlar. Geleneksel tıbbi bitkiler, sağlıklı yaşamın sürdürülmesi, günlük hayatta alınan toksinler, hastalıklarla mücadele ve önleme, uzun ömür gibi birçok araştırma ile desteklenmiş uzun bir geçmişe sahiptir. Etnomedikal bitkiler ve doğal fitokimyasalların antiviral, antiinflamatuar ve antioksidan özellikleri üzerine yapılan araştırmalar, Covid-19 tedavisinin yanısıra çeşitli rahatsızlıklara karşı büyük bir potansiyel ilaç kaynağı olarak kabul edilebilir. Bu çalışmadan yola çıkarak bitki özütlerinin Covid-19 gibi ölümcül sonuçlara yol açabilen viral enfeksiyonlarda beyaz kan hücrelerinin ve lenfositlerin sayısındaki yükselişle bağışıklığa arttırma, proinflamatuar sitokinlerin üretimini ve salımını düzenleme, C-reaktif protein ve eritrosit sedimantasyon oranındaki düşüşle anti-inflamatuar bir etki gösterme, virüsün gelişimine müdahale etme gibi olumlu etki ve potansiyel antiviral ajan aktivitesi sergilediği görülmektedir. Bu çalışmada COVID-19 enfeksiyonu ile ilişkili fitokimyasallar ve etkileri derlenmiştir
  • Küçük Resim
    Öğe
    Kuru kayısılardaki kükürt miktarının serum oksidatif stres parametleri üzerine etkisi
    (Pamukkale Üniversitesi, 2019) Otlu, Önder; Kıran, Tuğba Raika; Karabulut, Ercan; Bay Karabulut, Aysun
    Kayısı, dünyanın farklı bölgelerinde yetiştirilebilen ve ticari öneme sahip bir meyvedir. Kayısılar güneşte veya depolanma süresini uzatmak amacıyla kükürtle muamele edilerek kurutulmaktadır. Özellikle Avrupa Birliği ülkeleri ve ülkemizde kuru kayısıda bulunması gereken kükürt miktarı 2000 mg/L olarak belirlenmiştir ve bu miktar azaltılmak istenmektedir. Çalışmanın amacı, yüksek ve düşük kükürt içerikli kayısılarla beslenmenin serum oksidatif stres parametreleri üzerine etkilerini karşılaştırmaktır. Toplamda 84 adet Wistar albino rat, gün kurusu kayısı ve farklı miktarda kükürt içeren kuru kayısıların kullanıldığı yemlerle 12 hafta boyunca beslendi. Ratların serum Total antioksidan seviye, Total oksidan seviye, Malondialdehit ve Glutatyon seviyeleri ölçüldü. En yüksek total antioksidan seviye gün kurusu kayısı ile beslenen grupta, en düşük total antioksidan seviye ise 3000 mg/L grubunda gözlemlenmiştir. Malondialdehit seviyelerinde sadece 1000 mg/L grubunda, Glutatyon seviyelerinde ise 1000 mg/L, 2000 mg/L ve 3000 mg/L gruplarında anlamlı artışlar görülmüştür.
  • Küçük Resim
    Öğe
    Long-term effects of orchiopexy and orchiectomy on the testes of rats with testicular torsion
    (elsevier, 2022) Taşçı, Aytaç; Uğuralp, Sema; Akatlı , Ayşe Nur; Arslan ,Ahmet Kadir; Bay Karabulut, Aysun
    Introduction: Ischemia/reperfusion injury occurs after testicular torsion, levels of free oxygen radicals and inflammatory cytokines are increased in both the torsional and contralateral testis, leading to testicular injury. Objective: The present study investigated whether orchiopexy or orchiectomy after testicular torsion was superior in terms of fertility potential in the long term. Study design: Following 720°, 4h left testicular torsion, orchiectomy or orchiopexy was performed on 84 rats, which were then sacrificed and evaluated for testicular function at day 1, at 3 months and 6 months (n=14 per group). An additional 14 rats were in the control group. Results: Follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels were significantly lower in the orchiopexy group than the orchiectomy and control groups after 3 months. However, there were no significant differences in hormone parameters among the three groups after 6 months. The hormone levels, Johnsen score, seminiferous tubule diameter, and inducible nitric oxide synthase (iNOS) expression at 3 and 6 months were not significantly different between the orchiectomy group and controls. Histopathological analyses at 3 and 6 months indicated significant decreases in Johnsen score and seminiferous tubule diameter in the ipsilateral testis in the orchiopexy group. At 3 months, the level of iNOS expression in the contralateral testis was significantly lower in the orchiopexy group than in other groups. At 6 months, however, it was not significantly different between the orchiopexy and control groups. There were no significant differences in iNOS expression at 3 or 6 months in the orchiectomy group compared to controls. Discussion: The ipsilateral testis in the orchiopexy group began to atrophy at 3 months, and the degree of atrophy became more evident at 6 months. The level of iNOS expression was low in the bilateral testis at 3 months in the orchiopexy group, and sperm in the contralateral testis were not yet functionally healthy. The level of iNOS expression in the ipsilateral testis decreased further at 6 months in the orchiopexy group, while that in the contralateral testis returned to the normal level. Conclusion: Testicular functions were restored faster after orchiectomy compared to orchiopexy following testicular torsion. However, follow-up of the rats for 6 months demonstrated that orchiopexy or orchiectomy procedures conducted on the testicular torsion had no effect on future fertility potential after 4 hours of torsion.
  • Küçük Resim
    Öğe
    Microbial chondroitin sulfate in experimental knee osteoarthritis model investigation of chondroprotective effect
    (Verduci Editore, 2021) Sevimli, Reşit; Erenler, Ayşe Şebnem; Bay Karabulut, Aysun; Akpolat, Nusret; Geçkil, Hikmet
    OBJECTIVE: Chondroitin sulfate (CS) is a glycosaminoglycan with proven anti-inflammatory, anti-apoptotic, anti-oxidant properties. CS increases type II collagen and proteoglycan synthesis in human joint chondrocytes. CS can reduce the production of pro-inflammatory mediators and proteases to improve the anabolic/catabolic balance of the extracellular cartilage matrix (ECM). Due to these characteristics, it is a natural compound that is considered to be Symptomatic Slow-Acting Drugs for Osteoarthritis (SYSADOA). Microbial chondroitin sulfate (MCS) was produced from two different bacterial sources using biotechnological methods by our team. In this study, we aimed to apply microbially produced CS and bovine-derived commercial CS forms to rabbit knees with osteoarthritis experimentally and to evaluate the results. MATERIALS AND METHODS: In this study, a cruciate ligament cutting model was applied to 40 New Zealand rabbits to induce experimental osteoarthritis. Four weeks after the surgical procedure, rabbits were divided into 4 groups as control, animal-derived MCS, E coli-derived MCS and PaJC-derived MCS group. The standard rabbit diet was fed to the control group, and the other groups were additionally fed 17 mg/kg/day CS/MCS for 12 weeks. The rabbits were sacrificed at the 12th week after surgery and the preparations obtained were evaluated histopathologically. RESULTS: As a result, it was observed that regeneration tissue was statistically significant in histopathological cartilage tissue compared to the control group of CS developed from different sources given to rabbits with osteoarthritis. It was determined that among the CS groups produced from different sources, the group with the highest chondroprotective effect was MCS originating from E.coli. CONCLUSIONS: This vegan product (MCS), which we obtained as a result of our study, was produced by our team from a microbial source. According to our analysis, it has the potential to be an effective alternative therapy agent in the treatment of osteoarthritis.
  • Küçük Resim
    Öğe
    Pandemi Sürecinde Kadın: Bir Bilançoya Dair Düşünceler
    (Mobbing Eğitim Yardım Araştırma Derneği, 2021) Bay Karabulut, Aysun
    2019 sonlarında Çin’de ortaya çıkıp kısa sürede dünyaya yayılan Covid-19 pandemisi, sosyal, siyasal, ekonomik ve kültürel olarak küresel ölçekte birçok değişime neden oldu. Sözü edilen bu değişimlerin en önemlileri sosyal alanda yaşandı ve toplumsal kesimlerin bütününde derin etkiler meydana getirdi. Pandemi süreci ve zorunlu karantina uygulamalarından olumsuz anlamda en çok çok etkilenen toplumsal grup ise kadınlar oldu. Ev içinde aldıkları sorumluluk arttı, işlerini kaybettiler ve muhtelif şiddet türlerine maruz kaldılar. Bütün bunlara ilave olarak pandemi koşulları tarafından tetiklenen yoğun stres faktörleri nedeniyle psikolojik gerilimler de yaşadılar. Bu çalışmada pandemi sürecinin kadınlar üzerindeki etkileri değerlendirilmek istenmiştir. Pandeminin olumsuz etkilerinin ciddi bir bölümünün toplumsal cinsiyet temelli yerleşik kimlik algısı olduğuna işaret edilmiş, cinsiyet ekseninde kadınların özgül özelliklerini dikkate alan korunaklı alanın tahkim edilmesi gerektiği vurgulanmıştır. Toplumsal varoluşun belirleyici bir öğesi olarak kadının varoluşsal konumunun önemine dikkat çekilmiştir.
  • Küçük Resim
    Öğe
    Protective Effects of Grape Molasses and Resveratrol Against DMBA Induced Oxidative Stress in Rat Ovarian Tissues
    (2019) Kıran, Tuğba Raika; Otlu, Önder; Karabulut, Ercan; Bay Karabulut, Aysun
    Objective: The polyphenolic compound, resveratrol (3, 4’, 5-trihydroxystilbene), trans-resveratrol is a natural phytoalexin that exists in many different foods such as grape peel and seed, peanut, mulberry and blueberry. Molasses is a natural food obtained by boiling and concentrating fruit juices known to be rich in minerals such as iron, phosphorus, potassium, sodium, calcium and magnesium, and phosphoric acid, formic acid, organic acids and some vitamins. Polyphenolic compounds are natural antioxidants and are known to have protective effects against tissue damage caused by reactive oxygen species (ROS). In this study, we aimed to investigate the protective effects of grape molasses and resveratrol on ovarian damage induced by 7, 12-dimethylbenz [a] anthracene (DMBA). Methods: A total of 42 old female Wistar Albino rats, aged 18 weeks were divided into six groups. 10 mg/kg DMBA was injected in the rats in DMBA group subcutaneously on day 0 and day 7 while grape molasses feed with 20% grape molasses was given along with DMBA application to the rats in DMBA + grape molasses group. Resveratrol was administered by subcutaneous injection at 10 mg/kg/day to the DMBA + Resveratrol group, while only feed with 20% grape molasses was given to the grape molasses group. Resveratrol was administered by subcutaneous injection at 10 mg/kg/day to the resveratrol group. Results: GSH activity between the control group and molasses group, DMBA and DMBA + molasses groups and the control group and the DMBA + grape molasses groups was found statistically significant. Regarding the NO activity, the difference between the DMBA and resveratrol groups, DMBA and DMBA + resveratrol groups and the grape molasses and resveratrol groups was found statistically significant. MDA activity between DMBA + resveratrol and DMBA + grape molasses groups, and DMBA + grape molasses and grape molasses groups was found statistically significant. Conclusion: Molasses as one of the most important nutrient sources of Eastern and Central Anatolia was observed to decrease ovarian tissue oxidative damage induced with DMBA compared to resveratrol.
  • Küçük Resim
    Öğe
    Sistemik immun-inflamatuar indeks alzheimer hastalığının tanısı ve takibi için yeni bir gösterge olabilir mi?
    (MTÜ, 2022) Bolayır, Aslı; Bay Karabulut, Aysun
    Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease whose prevalence continues to increase in the elderly population. It has been shown that the neutrophil/lymphocyte ratio (NLR), is increased in AD compared to the normal population. However, there is no study in the literature regarding the role of systemic immune-inflammatory index (SII), which is calculated according to the formula of peripheral platelet count X neutrophil count/lymphocyte count, in AD. Therefore, our aim in this study was to reveal the role of SII in the diagnosis and follow-up of AD and to determine the relationship of this value with severity, duration of disease and drug use by comparing it with NLR. Materials and Methods: Our retrospective study consisted of 94 gender and age matched healthy volunteers and 102 patients who applied to our clinic were diagnosed with AD. Results: There was no difference between the patient and control groups in terms of age, gender, platelet and neutrophil counts, and SII values. While lymphocyte count was lower in-patient group; NLR and CRP detected higher (p=0.001, p=0.001, p=0.001, respectively). While SII increased as both disease duration and severity elevated; no statistically significant correlation was found between NLR and the severity and duration of the disease and drug use. Conclusions: Based on the data of our study, we can suggest that inflammatory process increases in AD. However, the relationship of this inflammatory process with the severity and duration of the disease and drug use is still unknown.
  • Küçük Resim
    Öğe
    Türkiye’de Yapılan Çalışmalar Bağlamında Kadınlarda Boşanmanın Nedenleri (2000-2018): Sistematik Derleme
    (2018-10-31) Kaplan, Sena; Abay, Halime; Bükecik, Esra; Şahin, Sevil; Arıöz Düzgün, Ayten; Bay Karabulut, Aysun
    Bu çalışmada Türkiye’de 2000-2018 yılları arasında yayımlanmış olan kadınlarda boşanma nedenlerinin araştırıldığı çalışmaların sistematik olarak incelenmesi amaçlanmıştır. Çalışmalar “Google Akademik” veri tabanında “boşanma nedenleri” ve “Türkiye” anahtar kelimeleri kullanılarak, “Google Scholar”, “Pubmed”, “ScienceDirect” veri tabanlarında ise “reason of divorce” ve “Turkey” anahtar kelimeleri kullanılarak taranmıştır. Tarama sonuçları “İngilizce sayfalardan ara” veya “Türkçe sayfalarda ara”, “2000-2018 yılları”, “Tam metin erişilebilenler”, “Türkiye’de gerçekleştirilenler”, “Nitel ve nicel araştırmalar”, “Boşanma nedenlerine yönelik bulgusu olanlar”, “Kadınlar ile gerçekleştirilenler” ve “Tekrar olan makalelerin çıkarılması” kriterleri kullanılarak sınırlandırılmıştır. Tarama sonucunda Google Scholar’da, Pubmed’te ve ScienceDirect’te dışlama kriterlerine göre uygun çalışmaya ulaşılamamıştır. Google Akademik’te yapılan taramada ise 148 makaleye ulaşılmıştır. Dışlama kriterlerine göre çalışmalar sınırlandırıldığında, 13 makale çalışmanın evrenini oluşturmuştur. Yapılan incelemede en dikkat çeken boşanma nedenlerinin “şiddet” ve “aldatılma” olduğu belirlenmiştir. “Şiddet” tüm çalışmalarda, “aldatılma” ise on iki çalışmada boşanma nedeni olarak gösterilmiştir. Çalışmaların yedisinde ise “aile üyelerinin olumsuz etkisi” ve “ekonomik sorunlar”; altısında “cinsel sorunlar” boşanma nedeni olarak belirtilmiştir. “Şiddetli geçimsizliğin” beş çalışmada ilk üç boşanma nedeni arasında yer aldığı dikkat çekmektedir. Ayrıca “kötü alışkanlıklar”, “ruhsal hastalıklar”, “sevgi eksikliği”, “aile rollerini yerine getirememe”, “kıskançlık”, “eşinden fazla gelire sahip olma” diğer boşanma nedenleri arasında yer almaktadır.