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    Causes of high erythrocyte sedimentation rates in elderly patients
    (2013) Uğuz, Nihal; Çelik, Hüseyin Tuğrul; Torun-Güngör, Oya; Bal, Ceylan Demir; Bakır, Fatih; Kazanci, Fatma; Yiğitoğlu, Ramazan
    Objective: The erythrocyte sedimentation rate (ESR) determination is a simple and inexpensive laboratory test that is frequently ordered in clinical medicine. The test measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. In this study it was aimed to determine the frequency of diseases which ESRs were over 100 mm/h in patients aged 65 and over. Method: In this study patients aged 65 and over who were treated in Turgut Özal University Hospital were retrospectively examined. Patients whose ESRs were over 100 mm/h were analyzed recording their ages, genders, ESRs and diagnoses. Diagnoses were divided into five groups: (i) infection; (ii) malignancy; (iii) inflammatory/connective tissue diseases; (iv) renal diseases; (v) miscellaneous diseases. Results: Two hundred five patients aged 65 and over whose ESRs were over 100 mm/h were analyzed. 115 of patients were women (56%) and 90 of them were men (44%). Age means of patients were 74.9 ± 6.45 and ESR means were 114.9 ± 14.8. When distribution according to disease groups was assessed, infection took the first rank (37.5%), malignancy took the second rank (21.9%), miscellaneous diseases took the third rank (21.4%), renal diseases took the forth rank (15.1%). The frequency of inflammatory/connective tissue diseases was 3.9%. Conclusion: In elderly, the most common cause of extreme elevation of ESR is infection. Different from other age groups, malignancy was found as the second common reason causing elevation of ESR. When etiology was researched in patients with extreme elevation of ESR, the age factor must be taken into consideration. © 2013 Elsevier B.V., All rights reserved.
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    Effect of different selenium levels on thyroid hormone synthesis
    (Refik Saydam National Public Health Agency (RSNPHA) turkhijyen@rshm.gov.tr, 2015) Bal, Ceylan Demir; Büyükşekerci, Murat; Ercan, Müjgan; Hocaoğlu, Asim; Çelik, Hüseyin Tuğrul; Abuşoğlu, Sedat; Tutkun, Engin
    Objective: As an essential element, selenium is very important for thyroid functions. Iodothyronine deiodinase-I is a selenium containing enzyme that is responsible for production of triiodothyronine (T3) from thyroxin (T4) in peripheral tissues. The aim of this study is to investigate the effect of different levels of selenium on thyroid hormone synthesis. Methods: 303 participants who had admitted to several clinics of Ankara Occupational Diseases Hospital and whose serum thyroid hormone and selenium levels were determined between years 2012 and 2014 were separated into 3 groups according to serum selenium levels. Group 1: 50-75?g/L, group 2: 75,1-100?g/L, group 3: 100,1-125?g/L. The thyroid stimulating hormone (TSH), free T3 (FT3) and free T4 (FT4) levels of groups were compared with each other. Results: There was statistically non-significant difference among 3 groups concerning the serum TSH and FT3 levels (p=0,91; p=0,18). Group 3 serum FT4 levels were lower than other groups. FT4 levels of group 3 were significantly different from group 1 (p= 0,005). T3/T4 ratio was significantly higher in group 3 than other groups (p=0,004). There was a negative correlation between selenium and FT4 levels (r=-0,184; p=0,001), whereas a positive correlation existed between selenium and T3/T4 ratio (r=0,178, p=0,002). Conclusion: Selenium has an important role in thyroid functions and FT4 levels increase in selenium deficiency. High FT4 levels should be considered in low selenium levels. © 2015 Elsevier B.V., All rights reserved.