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    Assessment of renal functions with different glomerular filtration rate formulas in children with acute exposure of mercury
    (Walter De Gruyter Gmbh, 2015) Bal, Ceylan; Gungor, Oya Torun; Celik, Huseyin Tugrul; Abusoglu, Sedat; Uguz, Nihal; Tutkun, Engin; Yilmaz, Omer Hinc
    Objective: Our aim was to determine whether cystatin C level has a superiority to creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute mercury exposure in children. Eight different glomerular filtration rate calculation formulas which have been used creatinine and/or cystatin C were also compared. Methods: Serum urea, creatinine and cystatin C values of 39 mercury exposed children were measured. Glomerular filtration rates were calculated by eight different formulas. Patient group was divided into three subgroups according to mercury levels. Results: Cystatin C and mercury levels of the patients were found significantly different from control group (p<0.001). There was not a significant difference in creatinine and urea values between two groups (p=0.913, p=0.236). There was not a significant difference between patient and control groups in GFR calculations which have been used serum creatinine and height or which have been used urea additional to them (p=0.069, p=0.559, p=0.424, p=0.945, respectively), but there was a significant difference between patient and control groups in GFR calculations which have been used cystatin C only or creatinine, urea and height in addition to this (p<0.001, p<0.001, p=0.042, p<0.001, respectively). In sugroup analysis, cystatin C results and the results of three GFR calculations of four GFR calculations which were used cystatin C were found different in control group according to subgroups but there was not a difference between subgroups. Conclusion: Cystatin C level is a better indicator than creatinine to assess kidney functions in rapid decreases of glomerular filtration rate due to acute exposure of mercury. Formulas using cystatin C gave better results than formulas using creatinine and height in estimation of glomerular filtration rate.
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    Mean platelet volume level in chromium exposed workers
    (Elsevier Ireland Ltd, 2014) Hocaoglu, Asim; Bal, Ceylan; Celik, Huseyin Tugrul; Abusoglu, Sedat; Yilmaz, Hinc; Tutkun, Engin
    [Abstract Not Available]
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    Serum asymmetric dimethylarginine and nitric oxide levels in Turkish patients with acute ischemic stroke
    (Wroclaw Medical Univ, 2019) Ercan, Mujgan; Mungan, Semra; Guzel, Isil; Celik, Huseyin Tugrul; Bal, Ceylan; Abusoglu, Sedat; Akbulut, Deniz
    Background. Nitric oxide synthase (NOS) is present in the brain and cerebral arteries and it enables the synthesis of nitric oxide (NO), which plays a critical role in brain perfusion. Asymmetrical dimethylarginine (ADMA) is an endogenous NOS inhibitor. Objectives. The aim of this study was to evaluate serum ADMA levels, which are an indicator of endothelial dysfunction of the renal functions in patients with acute ischemic stroke, and to determine whether there is a possible correlation between ADMA and NO levels and the L-arginine-to-ADMA ratio. Material and methods. Fifty-two patients (22 male and 30 female; mean age: 75.2 +/- 10.1 years) with a diagnosis of acute ischemic stroke in the first 24 h post-stroke and 48 healthy individuals (controls; 13 male and 35 female; mean age: 60.1 +/- 7.92 years) were included in this study. The risk factors recorded and evaluated were age and gender of the patients, serum lipid levels, serum ADMA levels, nitrate-to-nitrite ratios, l-arginine, l-arginine-to-ADMA ratios, sedimentation rate, C-reactive protein (CRP), urea and creatinine levels, and glomerular filtration ratio (eGFR). Results. The mean serum ADMA level was 0.48 +/- 0.23 mu M for the patients and 0.36 +/- 0.18 mu M for the controls. The mean NO level was 2.78 +/- 0.59 mu M for the patient group and 4.49 +/- 2.84 mu M for the controls. The ADMA levels for the patient group were significantly higher than for the control group (p = 0.011); the NO levels for the patients were significantly lower than for the controls (p < 0.001). The logistic regression method demonstrated that ADMA and NO levels may be independent risk factors for the patient group, and the receiver operating characteristic (ROC) curve analysis showed that both of these variables were discriminative risk factors. Conclusions. An increased serum level of the NOS inhibitor ADMA was found to be a possible independent risk factor for ischemic stroke.