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Öğe Benefits of the Neutrophil-to-Lymphocyte Ratio for the Prediction of Gestational Diabetes Mellitus in Pregnant Women(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2014) Yilmaz, H.; Celik, H. T.; Namuslu, M.; Inan, O.; Onaran, Y.; Karakurt, F.; Ayyildiz, A.Aims: There is growing consensus in the literature that inflammation plays a central role in the pathophysiology of obesity, Type 2 Diabetes Mellitus (T2DM), Gestational Diabetes Mellitus (GDM) and cardiovascular complications. Measuring the neutrophil-to-lymphocyte ratio (NLR) provides a simple inexpensive method for the assessment of inflammatory status. We investigated the predictive value of pre-procedural (before the oral glucose tolerance test (OGTT)) NLR on the development of GDM in pregnancy. Methods: 42 women with GDM and 68 women without GDM were included in the study. Complete Blood Count and biochemical tests were followed by a diagnostic 4-point 100-g-OGTT within 2 weeks. GDM was diagnosed by the Carpenter and Coustan criteria. The NLR was calculated from the data. Results: The mean NLR level was significantly higher in GDM women (3.00 +/- 0.83 vs. 2.26 +/- 0.43 p < 0.001, respectively). In ROC analysis, NLR > 2.93 had 76.2 % sensitivity and 94.1 % specificity in predicting GDM. Logistic regression analysis showed that elevated NLR (OR: 5.512, 95 % CI: 1.352-22.475, p = 0.017) was an independent variable for predicting GDM in pregnancy. Conclusions: An elevated NLR level is a powerful and independent predictor of GDM. The results of this study suggested that inflammation plays a central role in the pathogenesis of GDM.Öğe Increased Serum Levels Of GDF-15 are Associated with Cardiovascular Death, Subclinic Atherosclerosis in Patients on Maintenance Hemodialysis(Excerpta Medica Inc-Elsevier Science Inc, 2014) Yilmaz, H.; Celik, H. T.; Gurel, O. M.; Bilgic, M. A.; Namuslu, M.; Bozkurt, H.; Ayyildiz, A.[Abstract Not Available]Öğe Increased serum levels of GDF-15 associated with mortality and subclinical atherosclerosis in patients on maintenance hemodialysis(Urban & Vogel, 2015) Yilmaz, H.; Celik, H. T.; Gurel, O. M.; Bilgic, M. A.; Namuslu, M.; Bozkurt, H.; Ayyildiz, A.Background/aims. Increased carotid intima-media thickness (CIMT) was shown to be an independent predictor of cardiovascular (CV) mortality in dialysis patients and the general population. Growth differentiation factor 15 (GDF-15), a member of the transforming growth factor superfamily, is produced by cardiomyocytes and atherosclerotic lesions under stress conditions such as inflammation. We assessed associations between serum concentrations of GDF-15, mortality, and CIMT for subclinical atherosclerosis in hemodialysis (HD) patients. Methods. A total of 87 patients on maintenance hemodialysis and 45 sex-and age-matched healthy controls were included in this prospective study. Serum GDF-15 levels were measured by ELISA. CIMT was assessed by Doppler ultrasonography. The association between serum GDF-15 levels and mortality was assessed using Cox regression analysis with serum levels categorized into two groups according to the median value (328.18 pg/ml). Patients were followed for 2 years and cause-specific and all-cause mortality were determined. Results. The median level of serum GDF-15 was significantly higher in HD patients than controls [ 328 (198-522) vs. 176 (101-289) pg/ml, p<0.01, respectively]. Serum GDF-15 levels were correlated to CIMT (r=0.607, p<0.001), C-reactive protein (CRP; r=0.250, p=0.010), HD duration (r=0.376, p=0.004), and serum albumin (r=-0.156, p=0.030). The multivariate analysis revealed that GDF-15 was found to be an independent variable of CIMT in HD patients. In the study, the serum GDF-15 level was an independent marker of all-cause of mortality when adjusted for age, CRP, and history of diabetes mellitus. Conclusion. The relationship between serum GDF-15, mortality, and carotid artery thickening suggests that GDF-15 may be a novel marker of atherosclerosis, inflammation, and malnutrition in HD patients.Öğe Relationship Between Coronary Angiography Results And Levels Of Lipoprotein Phospholipase A2 And High-Sensitivity C-Reactive Protein(Excerpta Medica Inc-Elsevier Science Inc, 2014) Ayyildiz, A.; Yilmaz, H.; Celik, H. T.; Erdamar, H.; Namuslu, M.; Gurel, O. M.; Akcay, A.[Abstract Not Available]
