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Öğe A Case of Spontaneous Spinal Epidural Hematoma Mimicking Stroke(Turkish Neurological Soc, 2014) Koc, Emine Rabia; Acar, Burcu; Ayturk, Zubeyde; Cemil, Duran Berker; Kosehan, Dilek; Ilhan, AtillaSpontaneous spinal epidural hematoma is an uncommon cause of acute non-traumatic myelopathy and may present with various clinical phenotypes. It should be included in the differential diagnosis of the patients who have focal neurological findings suggestive of stroke. Therefore, a thorough documentation of patient history is of great importance, since this can reveal symptoms suggestive of a different etiology. Here, we present a case of a 80-year-old female who was admitted with hemiparesis without cortical or cranial neurological abnormalities. She described pre-existing shoulder and neck pain. Diagnosis of epidural hematoma was made by cervical magnetic resonance imaging. Symptoms resolved partially after surgical intervention. Our case illustrates the variation in the clinical presentations of spontaneous spinal epidural hematoma which can be misdiagnosed as stroke. Therefore, in patients with preceding neck, shoulder or interscapular pain and focal neurological deficits, this diagnosis should be included in the differential diagnosis, particularly in the absence of cortical and cranial symptoms.Öğe A comparison of hair and serum trace elements in patients with Alzheimer disease and healthy participants(Tubitak Scientific & Technological Research Council Turkey, 2015) Koc, Emine Rabia; Ilhan, Atilla; Ayturk, Zubeyde; Acar, Burcu; Gurler, Mukaddes; Altuntas, Aynur; Karapirli, MustafaBackground/aim: To determine whether there was a difference between serum and hair trace elements' concentrations in patients with Alzheimer disease (AD) and healthy participants. Materials and methods: Hair and serum copper, selenium, zinc, magnesium, manganese, and iron levels were measured by inductively coupled plasma-mass spectrometry in patients with AD and healthy participants, and the obtained results were statistically compared. Results: The mean hair selenium and zinc levels of patients with AD were significantly lower than the levels found for control participants (P < 0.05). Patients with AD had significantly higher mean hair copper and manganese levels than the controls. There were no significant differences between AD patients and controls with respect to the hair iron and magnesium levels (P > 0.05). Hair and serum trace element (copper, selenium, zinc, magnesium, manganese, and iron) levels in patients with AD showed no significant difference according to mini mental test scores or sex (P > 0.05). Conclusion: Some trace element levels may change in patients with AD. Due to the more permanent status, the analysis of these element levels in hair might be superior to blood analysis.Öğe Association among ABCA7 Gene Polymorphism, rs3764650 and Alzheimer's Disease in the Turkish Population(Canadian Soc Clinical Investigation, 2015) Oznur, Murat; Hatipoglu, Omer F.; Ayturk, Zubeyde; Dede, Serap; Akbas, Kubra; Aydin, Duygu; Urhan, AysePurpose: Alzheimer's disease (AD), the most common form of dementia, is an irreversible and progressive neurodegenerative disease that is characterized by the progressive loss of cognitive functions, behavioral and psychological disorders and a decrease in daily routine activities. Among people aged 65 years and over, AD is steadily increasing. Genome-wide association studies have shown that various gene polymorphisms are highly associated with the pathogenesis of AD. Among them, ABCA7 gene polymorphism has been identified as one of the genetic risks. The purpose of this study was to investigate the relationship among ABCA7 gene polymorphism, rs3764650 and AD, and to determine if it could be use as a biomarker for AD susceptibility in the Turkish population. Methods: Peripheral blood samples of 54 Alzheimer's patients and 57 control subjects were collected. Genomic DNA was isolated by SDS/proteinase K treatment followed by phenolchloroform extraction and ethanol precipitation. The presence of the ABCA7 gene rs3764650 polymorphism was investigated by PCR-RFLP and selected samples were confirmed by DNA sequencing. Results: In the Turkish population, the ABCA7 gene rs3764650 polymorphism did not show a significant association with AD when compared with the control group (p>0.05). APOE-epsilon 3 allele frequencies were higher in both AD patients and control subjects (76.85% and 84.21%, respectively). Conclusion: Both previously published studies and our current study did not cover the complete genetic variation in the gene. To detect variants that are disease-related, studies with larger sample sizes are needed.Öğe Association of Clusterin (CLU) Gene Polymorphism, Rs11136000, with Alzheimer's Disease and Diabetes in the Turkish Population(Canadian Soc Clinical Investigation, 2015) Ciftci-Yilmaz, Sultan; Oznur, Murat; Ayturk, Zubeyde; Dede, Serap; Cigdem, Sadik; Eroglu, Esra; Onal, FethiPurpose: Alzheimer's disease (AD), the most common form of dementia, is characterized by abnormal protein storage in the brain and primarily causes a progressive loss of memory and all other cognitive functions. According to the World Health Organization (WHO) report, AD is steadily increasing among people 65 years of age and over. Genome wide association studies have shown that various gene polymorphisms are highly associated with the occurrence of AD. Among them, clusterin (CLU) gene polymorphism was identified as one of the highest genetic risks in late-onset AD. Our aim was to investigate the relation of CLU rs11136000 and AD and its potential use as a biomarker for AD susceptibility in the Turkish population. Methods: 50 samples obtained from AD patients and 55 samples obtained from a control group were used for the presented study. Genomic DNA was isolated from peripheral blood by SDS/proteinase K treatment followed by phenol-chloroform extraction and ethanol precipitation. Presence of the CLU rs11136000 polymorphism was investigated by PCR-RFLP and selected samples were confirmed by DNA sequencing. Chi-square test was used for statistical analysis. Results: In the Turkish population, the CLU rs11136000 polymorphism did not show a significant association with AD as compared with the control group (p>0.05). Polymorphic CLU-C allele of AD patients showed an increased association with diabetes (p=0.015) as compared with CLU-T allele of AD patients, whereas in the control group the CLU-C allele did not show a significant association with diabetes (p=0.332). Conclusion: Individuals with diabetes and polymorphic CLU-C allele may have a higher susceptibility to develop AD later in life.Öğe HAIR AND SERUM TRACE ELEMENT LEVELS IN ALZHEIMER'S DISEASE(Elsevier Science Inc, 2014) Koc, Emine R.; Ayturk, Zubeyde; Ilhan, Atilla; Acar, Burcu; Gurler, Mukaddes; Bodur, M. Said[Abstract Not Available]Öğe Re-emergent tremor in Parkinson's disease: Clinical and accelerometric properties(Elsevier Sci Ltd, 2017) Ayturk, Zubeyde; Yilmaz, Rezzak; Akbostanci, M. CenkRe-emergent tremor (RET) and the classical parkinsonian rest tremor were considered as two different phenomena of the same central tremor circuit. However, clinical and accelerometric characteristics of these tremors were not previously compared in a single study. We evaluated disease characteristics and accelerometric measurements of two tremor types in 42 patients with Parkinson's disease. Disease specific features and accelerometric measurements of peak frequency, amplitude at peak frequency and the root mean square (RMS) amplitude of two tremor types were compared. Eighteen patients had RET and the mean latency of the RET was 9.48 (+/-9.2) s. Groups of only rest tremor and RET did not differ significantly in age of disease onset, disease duration and severity and mean levodopa equivalent dose. Comparison of peak frequency and amplitude at peak frequency were not different between the groups, but RMS amplitude was significantly higher in the RET group (p = 0.03). RMS amplitude of RET was also correlated with disease severity (r =.48, p = 0.04). These results support the previous notion that rest tremor and RET are analogue, both are triggered by the same central ossilator with RET being only the suppression of the rest tremor due to arm repositioning. (C) 2016 Elsevier Ltd. All rights reserved.Öğe Structural Changes in the Cerebrum, Cerebellum and Corpus Callosum in Migraine Patients(Canadian Soc Clinical Investigation, 2016) Demir, Berin T.; Bayram, Nezihe A.; Ayturk, Zubeyde; Erdamar, Husamettin; Seven, Pelin; Calp, Aysegul; Sazak, MervePurpose: The purpose of this study was to demonstrate the relationship among the cerebrum, cerebellum and corpus callosum in migraine patients. Methods: This work was conducted with cooperation of the Turgut Ozal Medical Faculty, Department of Anatomy and Neurology. Migraine patients were divided into four groups: new patients; 1-5 years; 5-10 years; and, more than 10 years. All patients (n=75) and control subjects (n=20) underwent Magnetic Resonance Imaging (MRI) and brain images were processed by ONIS and Image J. Data were analyzed using the planimetric method. Results: Cerebrum, cerebellum and corpus callosum volume were calculated for all subjects. The footprints of the callosum were as follows: healthy control subjects, new patients and 1-year patients: 12.8%, 5 years: 11.7% and more than 10 years: 10.7%. The cerebrum volume was as follows: healthy control subjects: 1152 cm(3), 5-10 years: 1102 cm(3) and more than 10 years: 1002 cm(3). Discussion: The results of our study showed atrophy in the cerebrum, cerebellum and corpus callosum of chronic migraine patients. This atrophy was greater in the patients with aura migraines. Conclusion: Our study confirmed that a migraine is an episodic disease that seriously affects the CNS.Öğe The effects and interactions of APOE and APH-1A polymorphisms in Alzheimer disease(Tubitak Scientific & Technological Research Council Turkey, 2015) Acar Cinleti, Burcu; Yardimci, Nilgul; Ayturk, Zubeyde; Ilhan, Atilla; Kaya, Gulhan; Acar, Muradiye; Koc, Emine RabiaBackground/aim: Alzheimer disease (AD) is characterized by the accumulation of senile plaques composed of amyloid beta-peptide, which is derived from beta-amyloid precursor protein through degradation by beta-secretase and.-secretase complexes. One of the major components of gamma-secretase complex, anterior pharynx-defective-1 (APH-1), is responsible for the activity of the.-secretase complex. In this study, we searched for not only the most known common genetic risk factor, APOE, but also the APH-1a gene polymorphism in AD patients in a Turkish population. Materials and methods: In this study, 49 AD patients and 45 healthy controls were included. The genetic polymorphisms and allele frequencies of APOE and APH-1a were investigated. Patients were evaluated for behavioral, cognitive, and functional domains by detailed neurocognitive tests, and comparison between the above-mentioned polymorphisms and disease severity was made. Results: Although there was an increased tendency of the APO epsilon 4 allele in the AD group, no statistically significant difference was detected either in APOE or APH-1a polymorphisms, not suggesting a strong susceptibility to the development of AD. Conclusion: While searching for the pathogenesis of AD in order to develop novel diagnostic as well as therapeutic approaches, analysis of other genes with a possible role in AD is warranted.Öğe The relationship between 25-hydroxyvitamin D levels and ambulatory arterial stiffness index in newly diagnosed and never-treated hypertensive patients(Lippincott Williams & Wilkins, 2016) Malcok Gurel, Ozgul; Bilgic, Ayse; Demircelik, Bora; Ozaydin, Meltem; Bozduman, Fadime; Ayturk, Zubeyde; Yilmaz, HakkiObjectivesVitamin D insufficiency has been shown to be associated with cardiac dysfunctions, such as cardiac hypertrophy and hypertension, in animal studies. Arterial stiffness is a prognostic marker for cardiovascular disease. Previous studies have demonstrated that 25-hydroxyvitamin D [25(OH)D] levels were negatively correlated with arterial stiffness index. The aim of this study was to investigate the relationship between 25(OH)D levels and arterial stiffness, which is evaluated using an ambulatory arterial stiffness index (AASI), in patients who have untreated and newly diagnosed essential hypertension.DesignA total of 123 consecutive patients with newly diagnosed and untreated essential hypertension were included. Patients were divided into two groups according to their 25(OH)D levels. Vitamin D insufficiency was defined by 25(OH)D levels less than 20ng/ml. All patients were referred for ambulatory blood pressure monitoring. The regression slope of diastolic and systolic blood pressure was computed for each individual on the basis of ambulatory blood pressure readings. AASI was described as one minus the respective regression slope.ResultsThe mean AASI was significantly higher in patients with 25(OH)D levels less than 20 as compared with patients with 25(OH)D levels greater than or equal to 20 (0.500.20 vs. 0.34 +/- 0.17, P<0.001). In Pearson's correlation analysis, AASI had a significantly strong negative correlation with vitamin D levels (r=-0.385, P<0.001). In multivariate linear regression analysis, vitamin D levels were found to be significantly and independently associated with AASI (=-0.317, P=0.035).ConclusionArterial stiffness measured by AASI in newly diagnosed and untreated patients with essential hypertension were significantly related to vitamin D levels.
