Yazar "Aydin, Merve" seçeneğine göre listele

Listeleniyor 1 - 7 / 7
  • Küçük Resim Yok
    Öğe
    Correlation of Neuroanatomical Structures Related to Speech in Cerebral Palsy Patients Aged 0-17: A Retrospective MRI Study
    (Mdpi, 2025) Berk, Erhan; Uzumcuoglu, Rumeysa; Inceoglu, Feyza; Aydin, Merve; Arpaci, Muhammed Furkan; Sigirci, Ahmet; Pekmez, Hidir
    Background/Objectives: Cerebral Palsy (CP) is a non-progressive clinical condition characterized by secondary issues, including speech impairments. Our study aims to evaluate the volumes of brain areas related to speech in patients diagnosed with CP between the ages of 0-17. Methods: this study includes the images of 84 children: 42 in the control group who applied to the hospital between the specified dates and were reported as healthy by MRI from the patient records, and 42 patients with CP. Results: in the CP group, white and gray matter, cerebrum, cerebellum, thalamus, lobus frontalis, lobus temporalis, lobus parietalis, lobus insularis, gyrus cinguli, and nuclei basales volumes were observed to decrease statistically significantly compared to the control group (p < 0.001). Conclusions: we found a significant decrease in the volumes of speech-related brain areas in CP patients, indicating that CP can significantly impact the brain's speech-related regions.
  • Küçük Resim Yok
    Öğe
    Correlation of the radial inclination angle in the distal part of the radius with the volar cortical angle and age-related changes of these angles
    (Military Medical Acad-Ini, 2023) Yazibasi, Husniye Tugba; Pekmez, Hidir; Agir, Ismail; Uckardes, Fatih; Zencirci, Busra; Aydin, Merve
    Background/ Aim. The radial inclination (RI) and volar cortical (VC) angle values used in the treatment of radial distal end fractures may vary depending on factors such as the age and gender of the patient. That raises the question of the compatibility of the standard anatomical plates, which are frequently used in the surgical treatment of these fractures. The aim of the study was to evaluate the VC and RI angles depending on the age and gender of subjects and determine the correlation between these two angles. Methods. A total of 121 individuals (59 females and 62 males) aged 10-65 years were included in the study. The individuals were divided into two groups: a group of 60 adolescents (31 females, 29 males) 10- 20 years old and a group of 61 adults (28 females, 33 males) aged 20-65 years. The subjects were also evaluated between themselves, independently, within each age group. Radiographic images were evaluated by using the 3.0.1.55 version of the KarPacsViewer application. Measurement points were determined, and angles between these points were measured. Statistical analyses were made using the SPSS 15.0 program. Results. When the correlation for 121 individuals was assessed independently of their gender, no statistically significant relationship was found between the RI angle and age (p = 0.616; r = -0.046). A statistically negative (or opposite) relationship was found between the VC angle and age (p < 0.001; r = -0.396). When women and men were compared in terms of the RI and VC angles, no statistically significant difference was found (p = 0.958, p = 0.165, respectively). The VC angle decreased as the age increased in females (p = 0.004; r = -0.365), while both the RI and VC angles decreased with increasing age in males (p = 0.032, r = -0.273; p < 0.0001, r = -0.445, respectively). Conclusion. Our findings regarding the RI and VC angles offer an advantage in terms of determining which plate designs are most appropriate for planning surgical procedures and treatment processes.
  • Küçük Resim Yok
    Öğe
    Investigation of the Effects of Light, Darkness, and Dim Light on Rat Brain Tissue: A Biochemical and Histological Study
    (Amer Chemical Soc, 2025) Pekmez, Hidir; Raika Kiran, Tugba; Tecellioglu, Fahriye Seccommail; Inceoglu, Feyza; Aydin, Merve; Zayman, Emrah; Canpolat, Sinan
    This study evaluates acetylcholinesterase (AChE) enzyme activity levels, oxidative stress parameters, histopathological findings, and serum melatonin levels in rat brain tissue. 32 male Wistar Albino rats were randomly divided into four groups: Control, Light, Dark, Dim light (n = 8 each group). After a 30 day experiment, brain tissues were collected to measure AChE, glutathione S-transferase (GST), glutathione (GSH), and malondialdehyde (MDA) levels and conduct histopathological analyses. Serum melatonin levels were also measured. In this study, we observed a significant increase in MDA levels in dim light, dark, and light groups. AChE and alpha-GST enzyme activity levels were significantly decreased in the dark group compared with the other groups. Additionally, there was a statistical difference in melatonin levels between the light and dark groups. In the light microscope examination of the sections stained with hematoxylin-eosin from the dark group brain tissue, mild perineuronal edema was observed in all areas. Our study is the first to compare the effects of three groups on the brain: continuous light, continuous darkness, and dim light at night. Additionally, it is the only study to examine the effects of light exposure differences on the brain AChE levels.
  • Küçük Resim Yok
    Öğe
    Investigation of the effects of pinealectomy on acetylcholinesterase enzyme activity and oxidative stress in rat brain
    (Springer Japan Kk, 2025) Pekmez, Hidir; Ozkaya, Ahmet; Uckun, Mirac; Zayman, Emrah; Aydin, Merve; Canpolat, Sinan; Gul, Mehmet
    The pineal gland releases melatonin to regulate our body's circadian rhythm based on light and dark cycles. The pinealectomy (PINX) model is an experimental approach employed to investigate the potential impact of melatonin on various tissues and pathologies. In this study, acetylcholinesterase (AChE) enzyme activity levels, oxidative stress parameters, histopathological findings, and serum melatonin levels in rat brain tissue were evaluated following pinealectomy. 24 male Sprague Dawley rats were randomly divided into groups: control, Sham-Pinealectomy (SHAM), and PINX. Brain tissue samples were taken at the end of a 50-day experimental period to determine the parameters of AChE, glutathione s-transferase (GST), carboxylesterase (Ces) enzyme activities, and malondialdehyde (MDA), reduced glutathione (GSH) levels spectrophotometrically. Moreover, serum melatonin levels were measured, and tissues underwent standard histological analysis to determine the histopathological damage score. In this study, we found that the PINX group had decreased AChE and Ces enzyme activity, increased MDA, decreased GSH levels, and no change in GST enzyme activity. A relative decrease in serum melatonin levels was also observed in the PINX group. In the light microscopic examination of the brain tissue of pinealectomy rats, it was observed that the eosinophilic staining intensity increased, heterochromatic/pycnotic-looking neuron nuclei were prominent in the cortex layers and hippocampus, and perineural edematous areas were abundant. Excessive perineuronal edema, cytoplasmic eosinophilia, and heterochromatic/pycnotic nuclei were found based on the histopathological damage score. After pinealectomy, we observed an increase in oxidative stress and a decrease in AChE levels in the brain.
  • Küçük Resim Yok
    Öğe
    Investigation of the effects of pomegranate juice against toxicity in the testes in lead-administered rats
    (Soc Anatomica Espanola, 2024) Pekmez, Hidir; Annac, Ebru; Bulmus, Ozgur; Uzun, Gokce Bagci; Aydin, Merve; Aydin, Ali
    Lead (Pb) is a heavy metal that can damage various organs, tissues, and systems. Antioxidants are used to prevent or reduce the negative effects of heavy metals. Pomegranate juice (PJ) is one the antioxidants that alleviate the harmful effects of heavy metals. In this study, 28 Wistar albino rats were divided into four groups. These groups were determined as control (C), lead acetate (LA) (50 mL/ kg per rat), PJ (1 mL), and LA + PJ. It was observed that the malondialdehyde level of the LA+PJ decreased compared to the LA. The glutathione level of the LA decreased compared to other groups. LA + PJ had higher glutathione S-transferase enzyme activity than C and lower than LA. Carboxylesterase activity increased in the LA + PJ compared C and LA. Pb level in the LA + PJ was higher than C and lower than LA. Also, Mn levels increased LA+PJ compared to LA. Testosterone decreased LA but increased in PJ and LA+PJ compared to LA. LA and PJ had similar histological structures to and PJ. It was determined that PJ had a curative effect against Pb toxicity in testicular tissue.
  • Küçük Resim Yok
    Öğe
    Investigation of the protective effect of Lavandula stoechas against the damage caused by Bisphenol A in the liver tissue of rats
    (Cell Press, 2024) Aydin, Merve; Kose, Evren; Karaca, Elif Taslidere; Tanbek, Kevser; Sandal, Suleyman
    The present study aims to explore the hepatoprotective potential of Lavandula stoechas (LS) against Bisphenol A (BPA)-induced liver toxicity. In this experiment, 32 male rats were utilized and categorized into control, LS, BPA, and BPA + LS groups for the study. Each group received 50 mg/kg of the respective substance. Throughout the 28-day experiment, the control group did not receive any applications. The LS oil was administered intraperitoneally, while BPA was given through oral gavage. At the end of the experiment, rats were anesthetized, and blood was taken from the heart. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TB) values were measured from serum samples. Malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) measurements were performed in liver tissue. The histological structure was observed using hematoxylin and eosin staining methods. The BPA group showed higher AST levels compared to the control group, but the BPA + LS group exhibited a significant decrease in AST levels compared to the BPA group. Additionally, TB levels were lower in the BPA + LS group compared to the BPA group. MDA levels increased in BPA-treated groups compared to others. The LS-treated groups showed higher SOD levels compared to the control group. Furthermore, an evident increase was noted in the BPA + LS group in comparison to the BPA group. The BPA group exhibited a significant rise in OSI value compared to the control. It was concluded that LS has a protective impact against BPA-induced liver toxicity. The LS-treated groups showed higher SOD levels compared to the control group. Furthermore, a significant increase was noted in the BPA + LS group in comparison to the BPA group. The BPA group exhibited a significant rise in OSI value compared to the control. It was concluded that LS has a protective impact against BPAinduced liver toxicity.
  • Küçük Resim Yok
    Öğe
    Morphometric Analysis of Female Pelvic Cavity Among Turkish Population: A Radiological Study
    (Springernature, 2025) Canbolat, Mustafa; Aydin, Merve; Bilge, Damla; Kaya, Anil; Arslan, Ahmet Kadir; Burulday, Veysel
    Background This study aims to reveal the characteristics of pelvic morphology in adult women within the Turkish population and to investigate age-related changes in pelvic region morphometry. Materials and Methods The study was conducted using CT images of 324 healthy women aged 18-60. Results A negative correlation with age was identified in all anatomical conjugate, obstetric conjugate, and diagonal conjugate values (p < 0.001). Furthermore, the differences between these pelvic diameters and age groups were statistically significant (p < 0.001, p < 0.001, p = 0.001). We did not detect any lateralization in the pelvis, except for the way the bones that make up the pubic symphysis meet each other. A significant difference was found for the subpubic angle among the age groups (p < 0.001). The distance between the anterior superior iliac spines (IADs) was positively correlated with age, and the differences in IADs values between age groups were also significant (p < 0.001). We found a significant difference in the pelvic inclination at the level of the inlet and outlet values among age groups (p < 0.001, p = 0.001). Conclusion It was observed that approximately 25% of our study cohort exhibited a spinous process extending downward from the superior margin of the greater sciatic notch, a feature that has not been previously documented in the literature. This spine may create pressure on the neurovascular structures passing through this region. We believe this structure deserves consideration in the causes of painful hip conditions.